36 research outputs found
Numerical modeling and performance analysis of zinc oxide (ZnO) thin-film based gas sensor
No full textAn Efficient Progressive Analysis on Different Dielectric Substrates to Design a Rectangular Microstrip Patch Antenna for Mobile Phones
No full textA Wireless Approach to Real Time Remote Monitoring System examining Environmental Parameters Using Feasibility of a GSM Module
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A Fascinating Territory Approaching Edge Detection Using Feasibility of Eigen Face to Identify an Individual
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Protection of the child/ elderly/ disabled/ pet by smart and intelligent GSM and GPS based automatic tracking and alert system
No full textAdvancements in Oncoproteomics Technologies: Treading toward Translation into Clinical Practice
No full textProteomics continues to forge significant strides in the discovery of essential biological processes, uncovering valuable information on the identity, global protein abundance, protein modifications, proteoform levels, and signal transduction pathways. Cancer is a complicated and heterogeneous disease, and the onset and progression involve multiple dysregulated proteoforms and their downstream signaling pathways. These are modulated by various factors such as molecular, genetic, tissue, cellular, ethnic/racial, socioeconomic status, environmental, and demographic differences that vary with time. The knowledge of cancer has improved the treatment and clinical management; however, the survival rates have not increased significantly, and cancer remains a major cause of mortality. Oncoproteomics studies help to develop and validate proteomics technologies for routine application in clinical laboratories for (1) diagnostic and prognostic categorization of cancer, (2) real-time monitoring of treatment, (3) assessing drug efficacy and toxicity, (4) therapeutic modulations based on the changes with prognosis and drug resistance, and (5) personalized medication. Investigation of tumor-specific proteomic profiles in conjunction with healthy controls provides crucial information in mechanistic studies on tumorigenesis, metastasis, and drug resistance. This review provides an overview of proteomics technologies that assist the discovery of novel drug targets, biomarkers for early detection, surveillance, prognosis, drug monitoring, and tailoring therapy to the cancer patient. The information gained from such technologies has drastically improved cancer research. We further provide exemplars from recent oncoproteomics applications in the discovery of biomarkers in various cancers, drug discovery, and clinical treatment. Overall, the future of oncoproteomics holds enormous potential for translating technologies from the bench to the bedside
Polarization and Strain in Piezoelectric Nanomaterials: Advancing Sensing Applications in Biomedical Technology
No full textThis paper reports the comparative analysis of different piezoelectric materials through a MEMS-based piezoelectric actuator model, emphasizing their potential for sensing applications. The polarization and electrostrictive strain tensor capabilities have been extensively studied for different piezoelectric materials such as PZT, LiNbO3, PVDF, etc. The simulation results obtained at varying voltages and mechanical stress demonstrate that LiNbO3 exhibits superior performance among the tested materials, with a polarization value of 0.5163 C/m2 at 800 volts and an electrostrictive strain tensor of 0.01 at an applied mechanical stress of 25 MPa. These findings will assist scientists in selecting the most suitable piezoelectric materials for sensing applications in biomedical fields
