89 research outputs found
The Neuropeptide VGF is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium
No full textRecent studies demonstrate that the neuropeptide VGF (non-acronymic) is regulated in the hippocampus by antidepressant therapies and animal models of depression and that acute VGF treatment has antidepressant-like activity in animal paradigms. However, the role of VGF in human psychiatric disorders is unknown. We now demonstrate using in situ hybridization that VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann’s Area 9 (BA9) of the prefrontal cortex. The mechanism of VGF in relation to LiCl was explored. Both LiCl intraperitoneally (IP) and VGF intracerebroventricularly (ICV) reduced latency to drink in novelty-induced hypophagia and LiCl was not effective in VGF+/- mice suggesting that VGF may contribute to the effects of LiCl in this behavioral procedure that responds to chronic antidepressant treatment. VGF by intrahippocampal injection also had novel activity in an amphetamineinduced hyperlocomotion assay thus mimicking the actions of LiCl injected IP in a system that phenocopies manic-like behavior. Moreover, VGF+/- mice exhibited increased locomotion following amphetamine and did not respond to LiCl, suggesting that VGF is required for the effects of LiCl in curbing the response to amphetamine. Finally, VGF by ICV in vivo activated the same signaling pathways as LiCl and is necessary for the induction of MAPK and AKT by LiCl thus lending insight into the molecular mechanisms underlying the actions of VGF. The dysregulation of VGF in bipolar disorder as well as the behavioral effects of the neuropeptide similar to LiCl suggests that VGF may underlie the pathophysiology of bipolar disorder.Peer reviewe
Performance Evaluation of MANETs with Variation in Transmission Power using Ad-hoc on-demand Multipath Distance Vector Routing Protocol
No full textAccelerating the execution of green hydrogen value chains with the use of programme management
No full textClimate change, driven primarily by carbon dioxide emissions, necessitates urgent action to decarbonize the energy sector. This urgency is highlighted by initiatives such as the European Green Deal aiming for a carbon-neutral European Union by 2050. The transition to green hydrogen contributes to reducing CO2 emissions, particularly in the Netherlands, where initiatives have been outlined but face challenges in execution. This research explores the application of programme management theory to accelerate the execution of green hydrogen value chains. Through literature study and semi-structured interviews, challenges in execution, such as cost, uncertainties, regulation, and lack of integration, are identified. Potential solutions include clarity on costs and regulations, long-term collaboration, improved communication and most importantly connection in the green hydrogen value chain. The application of program management, characterized by grouping projects, aligning objectives, and coordinating resources, emerges as a viable strategy. All the actors in the entire chain need to collaborate and work as one instead of working in isolation. A model is developed to guide the setup of programme management for a green hydrogen value chain, emphasizing clear goals, roles, and communication. This research contributes to filling gaps in the literature and offers practical insights for industry stakeholders to expedite the transition to green hydrogen. Recommendations include collaboration among sectors, regulatory clarity, and utilization of the developed model. Future research could focus on contract formation, broader application of the model, and addressing regulatory challenges at a policy level.Civil Engineering | Construction Management and Engineerin
Office-Based Anesthesia in Oral and Maxillofacial Surgery-The American Model and Training
No full textDigital gods: The making of a medical fact for rural diagnostic software
Get PDFThe chronic shortage of doctors in rural India seriously impacts the quality of health care available to villagers. In recent years, there has been considerable excitement in digital diagnostics as a possible answer to this situation by allowing non-doctors to diagnose and treat patients. In this article, the author focuses on one such diagnostic tool that has gained serious traction among transnational health foundations and state governments alike. The focus is on the customization and localization of this software through a pilot study in central Himalayas. A baseline survey and extensive interviews are conducted for categorization and population of health data content. This entailed analyzing the segmentation and transfer of health information on disease history and symptoms from the patient to the software as well as situating this study in the larger understanding of the healthcare system in this community. In doing so, the author argues that much of such health information is difficult to categorize and sufficiently vague to not provide for a confident diagnosis. Further, the data population of the treatment segment is deeply political and sociocultural. This article thereby problematizes the innate assumption underlying the design of such software, that it is possible to diagnose and treat patients based on pure information
Evaluation of AOMDV Routing Protocol for Optimum Transmitted Power in a Designed Ad-hoc Wireless Sensor Network
No full textStudies on Bioconjugation of Quantum Dots (nano particles)
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
3-STAGE SPECIALLY STRUCTURED FLOW SHOP SCHEDULING TO MINIMIZE THE RENTAL COST, SET UP TIME SEPARATED FROM PROCESSING TIME INCLUDING JOB WEIGHTAGE
Get PDFABSTRACT This article describe the development of a new heuristic algorithm which guarantees an optimal solution for specially structured flow shop problem with n-jobs,3-machines, to minimize the rental cost under specified rental policy in which set up times are separated from processes time, including job weightage. Further the processing times are not merely random but bear a well defined relationship to one another. Most of literature emphasized on minimization of idle time/ make span. But minimization of make span may not always lead to minimize rental cost of machines. Objective of this work is to minimize the rental cost of machines under a specified rental policy irrespective of make span
Application of Gold Nanoparticles and Quantum dots in Food Analysis
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
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