1,852 research outputs found

    First person – Jamie Whitelaw

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    First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Jamie Whitelaw is first author on ‘ CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge’, published in JCS. Jamie conducted the research described in this article while a post-doctoral researcher in Prof. Laura Machesky's lab at CRUK Scotland Institute, Glasgow, UK. He is now a Lecturer at University of the West of Scotland, Blantyre, investigating host–pathogen interactions with a focus on the role of the host cytoskeleton

    Kathleen Jamie, Chitra Ramaswamy & Amanda Thomson: Antlers of Water - Live Event

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    ‘When we read and write, when we love our fellow creatures, when we walk on the beach, when we just listen and notice, we are not little cogs in the machine, but part of the remedy.’ These luminous words by Kathleen Jamie form part of the introduction to Antlers of Water, an outstanding collection of contemporary Scottish writing about nature and landscape. The generosity of Jamie’s approach as editor of the collection goes beyond the stellar selection of contributors such as Amy Liptrot, Karine Polwart and Malachy Tallack: she also invokes the agency of readers to make a difference. ‘If, by reading, you are encouraged or confirmed in your love of the natural world, if you’re inspired simply to… look outside, then our job is done.’ In a discussion led by the BBC's Clare English, Jamie is joined by award-winning journalist Chitra Ramaswamy as well as visual artist and writer Amanda Thomson – both contributors to the anthology – to discuss Scotland, landscape and the more-than-human world around us. This is a live event, with an author Q&A. Part of the Edinburgh International Book Festival Making Climate Change Personal festival theme

    Fabrication and characterisation of CVD-graphene nanoribbon single electron transistors

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    Graphene was the first 2 dimensional material discovered and rapidly received a lot of attention because of its astounding properties. It is still the highest conductivity material recorded and very robust despite its single atomic layer thickness. However a key issue with graphene has been that it is a semimetal and not a semiconductor, so it lacks a band gap. Originally a large amount of focus was on researching methods to overcome this issue for logic devices. At first the patterning into nanoribbons was seen as a method to achieve this, but the fabrication of a nanoribbon came at a cost of graphene’s high mobility electrons. From conducting this research an interesting property of graphene emerged. It was capable of acting intrinsically as a single electron transistor, enabling a different type of more than Moore device to be fabricated that can be used in future nanoelectronic applications.The aim of this project has been to investigate the transport properties of polycrystalline graphene grown using chemical vapour deposition. The use of polycrystalline graphene enables the fabrication of wafer scale devices that can be stacked on a large variety of surfaces. So far though there has been a lack of investigation into the scaling effects of polycrystalline graphene nanoribbons and the single electron tunnelling properties associated with them. This work presents the first detailed investigation into their properties and shows that polycrystalline graphene can be used for producing high quality single electron transistors. Nanoribbons are fabricated down to sub 20 nm widths with high aspect ratio transitions from wide to narrow segments. The single electron transistor has demonstrated a single quantum dot impacted by the effect of energy level spacing

    The modernization of the Gothic heroine: from Ann Radcliffe to Stephenie Meyer, a feminist perspective

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    A comparative look at the Gothic heroine of Ann Radcliffe's "The Italian" versus the modern Gothic heroine portrayed in Stephenie Meyer's "Twilight" series.M.A.Includes bibliographical references (p. 32-33)Jamie T. Corso

    EADEM MUTATO RESURGO

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    Second edition of the same title first published in 1987. With a preface by Rodney Graham and in appendix essays by Jamie Hilder and Robert Linsley. Originally published in conjunction with the author's installation the same title, presented at the Art Gallery of Ontario from Nov. 28, 1987 to Jan. 31, 1988

    Jamie Callan, 26th Annual Literary Festival

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    Jamie Callan is author of three novels for young adults. Her fiction has appeared in Best American Erotica 2002, The Missouri Review, Story Buzz Magazine, American Letters and Commentary, OntheBus, The Baffler, and Turnstile. She has received grants and fellowships from the New York State Council on the Arts, the Connecticut Commission on the Arts, the Bread Loaf Writers Conference, Virginia Center for the Creative Arts, Ragdale, the Edna St. Vincent Millay Colony, the Helene Wurlitzer Foundation, and the Djerassi Foundation. She\u27s won the first prize in the Writers Digest Competition for literary fiction twice, a PEN Syndicated Fiction Award and a Goldwyn Award for Screenwriting. Callan teaches fiction at Yale University, NYU, and Wesleyan Universty. She is also a Master Teaching Artist with the Connecticut Commission on the Arts and was recently rated No.81 in Best American Erotica\u27s Readers Choice Top 100 erotica writers from the last 10 years

    Feeling Numbers: KP Brehmer and the Supermarket

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    A publication that documents the presentation of To refuse/To wait/To sleep and M&A beginning on January 12, 2017, and continuing until complete. Jamie Hilder contributes an essay about KP Brehmer.final article publishe

    Raw footage [possibly] for Jamie L. Whitten Campaign Commercials

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    Raw footage: Jamie Whitten conversing with students on a campus; unidentified man speaks about business development in Mississippi; scenes of construction work on a river bridge, a railroad bridge with oncoming train, a river barge, Parisienne automobile

    Looking and Laughing: Ken Lum at the Vancouver Art Gallery

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    Ken Lum’s recent survey at the Vancouver Art Gallery is reviewed by Jamie Hilder, who traces a distinct continuity in Lum’s employment of strategies that engage the viewer in a self-conscious and, at times, discomforting reading of his work. Lum demonstrates a particular propensity towards combining humour with sobering sociocultural issues that result in work that is immediately approachable yet provocatively disorienting.Peer reviewedfinal article publishe

    Functional Data Analysis Applied to Modeling of Severe Acute Mucositis and Dysphagia Resulting From Head and Neck Radiation Therapy

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    PurposeCurrent normal tissue complication probability modeling using logistic regression suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (RT) dose data. This hinders robust estimates of dose-response associations and, hence, optimal normal tissue–sparing strategies from being elucidated. Using functional data analysis (FDA) to reduce the dimensionality of the dose data could overcome this limitation.Methods and MaterialsFDA was applied to modeling of severe acute mucositis and dysphagia resulting from head and neck RT. Functional partial least squares regression (FPLS) and functional principal component analysis were used for dimensionality reduction of the dose-volume histogram data. The reduced dose data were input into functional logistic regression models (functional partial least squares–logistic regression [FPLS-LR] and functional principal component–logistic regression [FPC-LR]) along with clinical data. This approach was compared with penalized logistic regression (PLR) in terms of predictive performance and the significance of treatment covariate–response associations, assessed using bootstrapping.ResultsThe area under the receiver operating characteristic curve for the PLR, FPC-LR, and FPLS-LR models was 0.65, 0.69, and 0.67, respectively, for mucositis (internal validation) and 0.81, 0.83, and 0.83, respectively, for dysphagia (external validation). The calibration slopes/intercepts for the PLR, FPC-LR, and FPLS-LR models were 1.6/−0.67, 0.45/0.47, and 0.40/0.49, respectively, for mucositis (internal validation) and 2.5/−0.96, 0.79/−0.04, and 0.79/0.00, respectively, for dysphagia (external validation). The bootstrapped odds ratios indicated significant associations between RT dose and severe toxicity in the mucositis and dysphagia FDA models. Cisplatin was significantly associated with severe dysphagia in the FDA models. None of the covariates was significantly associated with severe toxicity in the PLR models. Dose levels greater than approximately 1.0 Gy/fraction were most strongly associated with severe acute mucositis and dysphagia in the FDA models.ConclusionsFPLS and functional principal component analysis marginally improved predictive performance compared with PLR and provided robust dose-response associations. FDA is recommended for use in normal tissue complication probability modeling
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