85 research outputs found
Sexual activity and health-related quality of life in heart failure : an exploration of the patients’ and healthcare providers’ perspective
No full textGender differences in risk factor management and pharmacological treatment among CHD patients: Belgian results of the EUROASPIRE IV and EUROASPIRE V surveys
No full textThe aim of this study was to provide an up-to-date overview of gender differences or similarities in risk factor control and medical management in the Belgian CHD population. All analyses are based on the ESC EORP EUROASPIRE IV and EUROASPIRE V (European Survey Of Cardiovascular Disease Prevention And Diabetes) surveys. Patients between 18 and 80 years old, hospitalised for a first or recurrent coronary event, were included in the survey. Data were available for 10,519 patients, of which 23.9% were women. Women had a worse risk factor profile compared to men. Women were more physical inactive (OR = 1.31, 95% CI = 1.19–1.44), had a higher prevalence of obesity (OR = 1.37, 95% CI = 1.25–1.50) and had a worse LDL-C control (OR = 1.52, 95% CI = 1.36–1.70). Moreover, women were less likely to use ACE-I/ARBs (OR = 0.84, 95% CI = 0.76–0.94) and statins (OR = 0.79, 95% CI = 0.70–0.90). In addition, little gender differences were found in patients’ risk factor awareness, except on cholesterol awareness. Women were more aware about their total cholesterol levels (OR = 1.37, 95% CI = 1.21–1.56). Despite little to no gender differences in the management of CHD patients, women still have a worse risk factor profile, both in Belgian and in other European high-income countries.</p
Real-time extracellular vesicle detection in blood plasma and serum using FO-SPR sensor
No full textstatus: Accepte
Migrer dans les Amériques
No full textNuméro coordonné par Virginie Baby Collin, Françoise Lestage, Paul Schor et Isabelle Vagnoux Ont également contribué à l’élaboration de ce numéro pour le comité de rédaction : Hélène Aji, Christian Azaïs, Mokhtar Ben Barka, Laurence Cros, Alvar de La LIosa, Vincent Dubreuil, Jean Kempf, Donna Kesselman, Frédéric Leriche, Delphine Mercier, Claire Parfait, Modesta Suárez Secrétariat de rédaction : Claire Bouffar
Migrer dans les Amériques
No full textNuméro coordonné par Virginie Baby Collin, Françoise Lestage, Paul Schor et Isabelle Vagnoux Ont également contribué à l’élaboration de ce numéro pour le comité de rédaction : Hélène Aji, Christian Azaïs, Mokhtar Ben Barka, Laurence Cros, Alvar de La LIosa, Vincent Dubreuil, Jean Kempf, Donna Kesselman, Frédéric Leriche, Delphine Mercier, Claire Parfait, Modesta Suárez Secrétariat de rédaction : Claire Bouffar
High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays
No full textRing
finger protein 41 (RNF41) is an E3 ubiquitin ligase involved
in the ubiquitination and degradation of many proteins including ErbB3
receptors, BIRC6, and parkin. Next to this, RNF41 regulates the intracellular
trafficking of certain JAK2-associated cytokine receptors by ubiquitinating
and suppressing USP8, which, in turn, destabilizes the ESCRT-0 complex.
To further elucidate the function of RNF41 we used different orthogonal
approaches to reveal the RNF41 protein complex: affinity purification–mass
spectrometry, BioID, and Virotrap. We combined these results with
known data sets for RNF41 obtained with microarray MAPPIT and Y2H
screens. This way, we establish a comprehensive high-resolution interactome
network comprising 175 candidate protein partners. To remove potential
methodological artifacts from this network, we distilled the data
into a high-confidence interactome map by retaining a total of 19
protein hits identified in two or more of the orthogonal methods.
AP2S1, a novel RNF41 interaction partner, was selected from this high-confidence
interactome for further functional validation. We reveal a role for
AP2S1 in leptin and LIF receptor signaling and show that RNF41 stabilizes
and relocates AP2S1
The relationship of multimorbidity with disability and frailty in the oldest patients: A cross-sectional analysis of three measures of multimorbidity in the BELFRAIL cohort
No full textBackground: Ageing people show increasing morbidity, dependence and vulnerability. Objectives: To compare the relationships of different measures of multimorbidity with dependence (operationalized as disability) and vulnerability (operationalized as frailty). Method: A cross-sectional analysis within the BELFRAIL cohort (567 subjects aged ≥ 80). Multimorbidity was measured using a disease count (DC), the Charlson comorbidity index (CCI) and the cumulative illness rating scale (CIRS), respectively. Associations with disability (based on activities of daily living) and frailty (defined by the Fried frailty criteria) were assessed using bivariable and multivariable analyses. Net reclassification improvement (NRI) values were calculated to compare the abilities of the DC, CCI and CIRS to identify patients with disability or frailty. Results: Disability was associated with the DC (crude odds ratio, OR: 2.1; 95% confidence interval, CI: 1.4-3.4), CCI (crude OR: 1.8; 95% CI: 1.2-2.7) and CIRS (crude OR: 4.0; 95% CI: 2.5-6.5); only the association with CIRS was independent of age, sex, chronic inflammation, impaired cognition and frailty (adjusted OR: 3.2; 95% CI: 1.7-5.8). Frailty was associated with CCI (crude OR: 2.4; 95% CI: 1.2-4.6) and CIRS (crude OR: 2.6; 95% CI: 1.3-5.3); adjusted for age, sex, chronic inflammation, impaired cognition and disability. These associations were not statistically significant. The NRIs demonstrated a similar ability of the DC, CCI, and CIRS to identify patients with disability or frailty, respectively. Conclusion: The associations of different measures of multimorbidity with disability and frailty differ but their ability to identify patients with disability or frailty is similar. Generally, multimorbidity scores incompletely reflect dependence and vulnerability in this age group
Capturing salmonella SspH2 host targets in virus-like particles
No full textIn the context of host-pathogen interactions, gram-negative bacterial virulence factors, such as effectors, may be transferred from bacterial to eukaryotic host cytoplasm by multicomponent Type III protein secretion systems (T3SSs). Central to Salmonella enterica serovar Typhimurium (S. Typhimurium) pathogenesis is the secretion of over 40 effectors by two T3SSs encoded within pathogenicity islands SPI-1 and SPI-2. These effectors manipulate miscellaneous host cellular processes, such as cytoskeleton organization and immune signaling pathways, thereby permitting host colonization and bacterial dissemination. Recent research on effector biology provided mechanistic insights for some effectors. However, for many effectors, clearly defined roles and host target repertoires-further clarifying effector interconnectivity and virulence networks-are yet to be uncovered. Here we demonstrate the utility of the recently described viral-like particle trapping technology Virotrap as an effective approach to catalog S. Typhimurium effector-host protein complexes (EH-PCs). Mass spectrometry-based Virotrap analysis of the novel E3 ubiquitin ligase SspH2 previously shown to be implicated in modulating actin dynamics and immune signaling, exposed known host interactors PFN1 and-2 besides several putative novel, interconnected host targets. Network analysis revealed an actin (-binding) cluster among the significantly enriched hits for SspH2, consistent with the known localization of the S-palmitoylated effector with actin cytoskeleton components in the host. We show that Virotrap complements the current state-of-the-art toolkit to study protein complexes and represents a valuable means to screen for effector host targets in a high-throughput manner, thereby bridging the knowledge gap between effector-host interplay and pathogenesis.</p
The detrimental impact of drop-out in cardiac rehabilitation on outcome among coronary artery disease patients
No full text- …
