593 research outputs found
R. De Schepper. Inleiding tot de studie der Kerkgeschiedenis
No full textVander Linden Herman. R. De Schepper. Inleiding tot de studie der Kerkgeschiedenis. In: Revue belge de philologie et d'histoire, tome 3, fasc. 1, 1924. p. 149
Stochastic approximations of present value functions.
No full textThe aim of the paper is to apply the method proposed by Denuit, Genest and Marceau (1999) for deriving stochastic upper and lower bounds on the present value of a sequence of cash flows, where the discounting is performed under a given stochastic return process. The convex approximation provided by Goovaerts, Dhaene and De Schepper (1999) and Goovaerts and Dhaene (1999) is then compared to these stochastic bounds. On the basis of several numerical examples, it will be seen that the convex approximation seems reasonable.Value; Functions;
A straightforward analytical calculation of the distribution of an annuity certain with stochastic interest rate.
No full textStarting from the moment generating function of the annuity certain with stochastic interest rate written by means of a time discretization of the Wiener process as an n-fold integral, a straightforward evaluation of the corresponding distribution function is obtained letting n tend to infinity. The advantage of the present method consists in the direct calculation technique of the n-fold integral, instead of using moment calculation or differential equations, and in the possible applicability of the present method to varying annuities which could be applied to IBNR results, as well as to pension fund calculations, etc.Distribution; Annuities; Processes; Evaluation;
Transition probabilities for diffusion equations by means of path integrals.
No full textIn this paper, we investigate the transition probabilities for diffusion processes. In a first part, we show how transition probabilities for rather general diffusion processes can always be expressed by means of a path integral. For several classical models, an exact calculation is possible, leading to analytical expressions for the transition probabilities and for the maximum probability paths. A second part consists of the derivation of an analytical approximation for the transition probability, which is useful in case the path integral is too complex to be calculated. The approximation we present is based on a convex combination of a new analytical upper and lower bound for the transition probabilities. The fact that the approximation is analytical has some important advantages, e.g. for the investigation of Asian options. Finally, we demonstrate the accuracy of the approximation by means of a few graphical illustrationsAdvantages; Comonotonicity; Diffusion processes; Models; Option; Path integral;
Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit
No full textThe cerebellar network is renowned for its regular architecture that has inspired foundational computational theories. However, the relationship between circuit structure, function and dynamics remains elusive. To tackle the issue, we developed an advanced computational modeling framework that allows us to reconstruct and simulate the structure and function of the mouse cerebellar cortex using morphologically realistic multi-compartmental neuron models. The cerebellar connectome is generated through appropriate connection rules, unifying a collection of scattered experimental data into a coherent construct and providing a new model-based ground-truth about circuit organization. Naturalistic background and sensory-burst stimulation are used for functional validation against recordings in vivo, monitoring the impact of cellular mechanisms on signal propagation, inhibitory control, and long-term synaptic plasticity. Our simulations show how mossy fibers entrain the local neuronal microcircuit, boosting the formation of columns of activity travelling from the granular to the molecular layer providing a new resource for the investigation of local microcircuit computation and of the neural correlates of behavior
Multi-compartmental reconstruction and simulations of an entire module of the mouse cerebellar cortex
No full textStarting Collaborations in the Food & Beverage Industry: A case study on the implementation of a novel packaging technology in new products
No full textIndustrial Design EngineeringStrategic Product Desig
De consequenties van marketing voor de rol van de medisch specialist
No full textThe medical specialist must perform his duties in a fundamentally changed environment. These changes have come from various directions - the healthcare consumer has been introduced into the spectrum, the method of financing and the legislation is currently being adjusted, the organisation in which he works is constantly subject to change - in short a dynamic world. Some of the changes can be seen as opportunities and by developing a strategic marketing plan, can become an advantage for the organisation.
The central question for this research is: what role could the medical specialist play in developing a strategic marketing policy in a general hospital?
Firstly, having investigated which marketing models are available, it turns out that marketing services in the commercial sector are very similar to the work environment of the medical specialist. A large amount of marketing competencies can be easily transferred to the area of healthcare although some adjustments are necessary. For example, anticipating the decision-making process of the healthcare consumer, and allowing the medical specialist to influence this process in the right way, would lead to a greater appreciation of some aspects of the health services by both patients and society.
Interviews with experts and the institutes show that the current medical specialists have to look on an different way to there healthcare consumers he has to realise an other relationship. By this new relationship he can better look for and fulfil the desire of the healthcare consumers, on this way he will become an entrepreneur.
The medical specialist becomes by all these changes an other role as doctor, but without the will of one’s own it is not possible to change.
Not only must the medical specialist change his perception, but also the organisation in which he works must adapt to new opinions about the market and the demands of the healthcare consumer. It is important that medical specialists and management together set a target and are intrinsically motivated to meet it. In this way, they can harness the changing market and use it as an opportunity.De medisch specialist moet zijn werkzaamheden verrichten in een sterk veranderende omgeving. Deze veranderingen komen uit diverse richtingen, de zorgconsument doet zijn intrede, de financiering en wetgeving worden aangepast, de organisatie waar hij in werkt is onderhevig aan veranderingen, kortom een dynamische wereld. Een aantal veranderingen kunnen gezien worden als kansen. Deze veranderingen kunnen door het ontwikkelen van een strategisch marketingplan met marketinginstrumenten de werksituatie ombuigen naar een voordeel situatie voor de organisatie.
Voor dit onderzoek is de centrale probleemstelling; Welke rol kan de medisch specialist innemen en ontwikkelen bij de uitvoering van het strategisch marketing beleid in een algemeen ziekenhuis?
In eerste instantie wordt bekeken welke marketingconcepten aanwezig zijn in de literatuur en dan blijkt dat dienstenmarketing in de commerciële branche zeer nauw aansluit bij de werksituatie van de medisch specialist. Enige aanpassingen zijn noodzakelijk, maar een groot aantal competenties zijn in de zorg goed te gebruiken. Hierbij hoort ook het inspelen op het besluitvormingsproces van de zorgconsument; door als medisch specialist op de juiste wijze dit besluitvormingsproces te beïnvloeden zullen een aantal aspecten van de dienstverlening beter gewaardeerd worden door patiënten en de maatschappij.
Het blijkt na onderzoek bij de experts en de casusinstellingen dat een medisch specialist op een andere manier naar zijn klanten moet kijken, hij moet een andere relatie aangaan. Door deze andere relatie, kan de medisch specialist ook beter op zoek gaan naar de wensen van zijn zorg consument en daarop inspelen. Hierdoor ontstaat een ondernemende medisch specialist die gaat inspelen op de veranderende markt zodat de vraag van de zorgconsument meer invloed gaat uitoefenen.
De medisch specialist gaat door deze veranderingen wel een andere rol krijgen als medicus, een belangrijk basis voorwaarde is dat hij de wil moet hebben om te veranderen. Naast de veranderingen van de medisch specialist moet ook de organisatie waar hij werkt adapteren aan de nieuwe inzichten over de markt en wensen van de zorgconsumenten. de medisch specialist en het management moeten gezamenlijk een doel stellen en dit ook samen vanuit intrinsieke motivatie realiseren. Op deze wijze kunnen zij de veranderende markt als kans benutten
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