1,721,119 research outputs found
NONSURGICAL APPROACH TO GALLSTONES - ORAL-THERAPY WITH BILE-ACIDS
No full textGallstone disease is very common. According to recent epidemiological studies it affects 6.4% of men and 10.4% of women between 30-69 years of age. In more than half of these the disease remains asymptomatic. Until fairly recently cholecystectomy was the only available treatment. However, in the early '70's, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) were introduced as possible alternatives to surgery. Nonetheless, not everyone with gallstones can or should be given this type of treatment. Whilst it is commonly agreed that symptomatic gallstones must be operated on, there is no such agreement regarding treatment with biliary acid per os for asymptomatic stones. However, only asymptomatic subjects with radiolucent stones in a functioning gallbladder, no larger than 15 mm in diameter, can be treated with a good rate of success-as high as 50% after one year of treatment. The biliary acid currently used, either alone or together with CDCA, is UDCA. The average dose is 8-10 mg/kg/day. There are few side effects and in practice there are no contraindications to such treatment. The cost of the treatment is not prohibitive: 750 mg/day of UDCA in Italy costs about $1540 for a year's supply
Beta adrenergic receptors in the parathyroid glands.
No full textThe location of β-adrenoceptors in human parathyroid gland was studied using an immunohistochemical method. Frozen sections of human parathyroid glands, taken from surgical samples, were treated with (-)-alprenolol, washed and exposed to (-)-alprenolol antibodies conjugated with fluorescent dyes. The (-)-alprenolol was bound to the parathyroid principal cells and to the main blood vessels. On the contrary, adrenergic nerve fibres, demonstrated with formaldehyde fluorescence technique, were only located within the walls of main blood vessels. The findings are discussed
NATURAL-HISTORY OF GALLSTONES (GS) - A 4 TO 6 YEAR FOLLOW UP STUDY OF ASYMPTOMATIC AND SYMPTOMATIC PTS
No full textPrevalence of portal vein thrombosis (PVT) and associated factors in non HCC cirrhotic patients
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