1,721,088 research outputs found
OVERALL TRADE TRADE SPECIALIZATION AND ECONOMIC DEVELOPMENT: COUNTRIES DIVERSIFY.
No full textFORTHCOMING THE REVIEW OF WORLD ECONOMICS. ISSN: 1610-2878
Distance-varying assortativity and clustering of the international trade network-ADDENDUM
No full textNetwork Analysis of World Trade using the BACI-CEPII dataset
Get PDFIn this paper we explore the BACI-CEPII database using Network Analysis. Starting from the visualization of the World Trade Network, we then define and describe the topology of the network, both in its binary version and in its weighted version, calculating and discussing some of the commonly used network's statistics. We finally discuss some specic topics that can be studied using Network Analysis and International Trade data, both at the aggregated and sectoral level. The analysis is done using multiple software (Stata, R, and Pajek). The scripts to replicate part of the analysis are included in the appendix, and can be used as an handson tutorial. Moreover,the World Trade Network local and global centrality measures, for the unweighted and the weighted version of the Network, calculated using the bilateral aggregate trade data for each country (178 in total) and each year (from 1995 to 2010,) can be downloaded from the CEPII webpage
HYPERGLYCEMIA-MEDIATED OVEREXPRESSION OF CYCLOOXYGENASE-2 (COX-2) PARTICIPATES IN VASCULAR HYPOREACTIVITY OF STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES
No full textSegregation with social linkages: Evaluating Schelling’s model with networked individuals
Get PDFThis paper generalizes the original Schelling model of racial and residential segregation to a context of variable externalities due to social linkages. In a setting in which individuals’ utility function is a convex combination of a heuristic function à la Schelling, of the distance to friends, and of the cost of moving, the prediction of the original model gets attenuated: the segregation equilibria are not the unique solutions. While the cost of distance has a monotonic pro-status-quo effect, equivalent to that of models of migration and gravity models, if friends and neighbors are formed following independent processes, the location of friends in space generates an externality that reinforces the initial configuration if the distance to friends is minimal, and if the number of friends is high. The effect on segregation equilibria crucially depends on the role played by network externalities
An epitope platform for safe and effective HTLV-1-immunization: Potential applications for mRNA and peptide-based vaccines
Get PDFHuman T-cell lymphotropic virus type 1 (HTLV-1) infection affects millions of individuals worldwide and can lead to severe leukemia, myelopathy/tropical spastic paraparesis, and numerous other disorders. Pursuing a safe and effective immunotherapeutic approach, we compared the viral polyprotein and the human proteome with a sliding window approach in order to identify oligopeptide sequences unique to the virus. The immunological relevance of the viral unique oligopeptides was assessed by searching them in the immune epitope database (IEDB).We found that HTLV-1 has 15 peptide stretches each consisting of uniquely viral non-human pentapeptides which are ideal candidate for a safe and effective anti-HTLV-1 vaccine. Indeed, experimentally validated HTLV-1 epitopes, as retrieved from the IEDB, contain peptide sequences also present in a vast number of human proteins, thus potentially instituting the basis for cross-reactions. We found a potential for cross-reactivity between the virus and the human proteome and described an epitope platform to be used in order to avoid it, thus obtaining effective, specific, and safe immunization. Potential advantages for mRNA and peptide-based vaccine formulations are discussed
- …
