2,579 research outputs found
Davide Leogrande | Architetto | Portfolio
No full textRaccolta sintetica dei principali progetti redatti dall'autore, Davide Leogrande, in qualità di studente nel corso di Laurea magistrale in Architettura a ciclo unico dell'Università di Roma Sapienza
Exploring biological signals: from pathway visualization to spatial transcriptomics.
No full textThe present Ph.D. thesis describes different projects concerning two main topics: visualization of biological networks and the identification of spatially variable genes (SVGs), which are genes that have a spatial pattern of expression. They can be identified from Spatially Resolved Transcriptomics (SRT) data, as it preserves spatial information of the tissue's cells. Although those projects are involved in two different topics, they share a common theme, the visualization of biological data. It is essential to access network information and to visualize a clear spatial pattern of expression of the SVGs identified, which can be related to the spatial changes of the tissue under study.
The main project of the thesis is itGraph, which concerns a novel web tool to explore pathways of interest with three different network perspectives. To enhance the visualization of the provided biological networks, it integrates features that are still lacking in other similar software, which also improve the tool's utility and the user experience.
For this project, I developed a pipeline to import pathways from the R package graphite (Sales et al. 2012) and created the above-mentioned three network perspectives. The pipeline also includes a strategy to pre-compute their layout before the actual visualization. Furthermore, I optimized all the scripts, the server (backend), the database, and the client (frontend), including the graphical interface of the entire tool.
The second project concerning network visualization is called MyoData, which was completed and published in the “Computational and Structural Biotechnology Journal”. It is a comprehensive and integrated resource for single myofiber and nucleus miRNA:lncRNA:mRNA coregulatory networks, also evaluating their impact in relation to known pathways such as those present in the KEGG collection. It integrates a minimal version of the network visualization tool used in itGraph.
The aim of the other two projects regards the identification of SVGs. At first, I describe SpatialDE, an R package wrapping of the SpatialDE Python method. It was created to respond to a challenge proposed at the EuroBioc2020 Conference and was published on Bioconductor in October 2021.
The last project is called VoyageR. The objective was to conduct a benchmark of computational methods to identify SVGs. This kind of study can be an important guide that can help users to choose the best suitable method for their use. Moreover, new methods for performing this type of analysis continue to be published. For this reason, my project not only benchmarks a large number of published pipelines but was designed to be extensible in order to simplify the addition of further methods.The present Ph.D. thesis describes different projects concerning two main topics: visualization of biological networks and the identification of spatially variable genes (SVGs), which are genes that have a spatial pattern of expression. They can be identified from Spatially Resolved Transcriptomics (SRT) data, as it preserves spatial information of the tissue's cells. Although those projects are involved in two different topics, they share a common theme, the visualization of biological data. It is essential to access network information and to visualize a clear spatial pattern of expression of the SVGs identified, which can be related to the spatial changes of the tissue under study.
The main project of the thesis is itGraph, which concerns a novel web tool to explore pathways of interest with three different network perspectives. To enhance the visualization of the provided biological networks, it integrates features that are still lacking in other similar software, which also improve the tool's utility and the user experience.
For this project, I developed a pipeline to import pathways from the R package graphite (Sales et al. 2012) and created the above-mentioned three network perspectives. The pipeline also includes a strategy to pre-compute their layout before the actual visualization. Furthermore, I optimized all the scripts, the server (backend), the database, and the client (frontend), including the graphical interface of the entire tool.
The second project concerning network visualization is called MyoData, which was completed and published in the “Computational and Structural Biotechnology Journal”. It is a comprehensive and integrated resource for single myofiber and nucleus miRNA:lncRNA:mRNA coregulatory networks, also evaluating their impact in relation to known pathways such as those present in the KEGG collection. It integrates a minimal version of the network visualization tool used in itGraph.
The aim of the other two projects regards the identification of SVGs. At first, I describe SpatialDE, an R package wrapping of the SpatialDE Python method. It was created to respond to a challenge proposed at the EuroBioc2020 Conference and was published on Bioconductor in October 2021.
The last project is called VoyageR. The objective was to conduct a benchmark of computational methods to identify SVGs. This kind of study can be an important guide that can help users to choose the best suitable method for their use. Moreover, new methods for performing this type of analysis continue to be published. For this reason, my project not only benchmarks a large number of published pipelines but was designed to be extensible in order to simplify the addition of further methods
Davide Angeli
No full textIl saggio ricostruisce le vicende della vita di Davide Angeli, ingegnere comunale e patriota nella Cesena di metà Ottocento, sottolineando il suo contributo alla causa dell'unificazione italiana.
Il saggio è il risultato di un lavoro di ricerca condotto negli archivi locali, che ha permesso di mettere in luce il contributo di Davide Angeli al rinnovamento urbano nel corso dell'Ottocento, con la costruzione di alcuni edifici pubblici ed attrezzature tipici della città borghese, e la predisposizione dei primi piani regolatori di ampliamento
Narrare la festa in Piemonte, documentari video. La ricerca è stata coordinata da Piercarlo Grimaldi, Davide Porporato e Gianpaolo Fassino. La regia dei documentari audiovisivi è di Stefano Cavallotto, Andrea Icardi, Luca Ghiardo, Dario Leone e Luca Percivalle.
No full textIl progetto, finanziato dalla “Direzione promozione della Cultura, del Turismo e dello Sport” della Regione Piemonte, è stato realizzato dall’Università di Scienze Gastronomiche-Laboratorio “Granai della Memoria” in partenariato con l’Università degli Studi del Piemonte Orientale – Dipartimento di Studi Umanistici. Il progetto ha valorizzato – attraverso la realizzazione di alcuni documentari video – il patrimonio etnografico e audiovisuale, raccolto nel corso degli anni da un gruppo di antropologi, nell’ambito delle attività di studio sulla cerimonialità festiva piemontese. La ricerca è stata coordinata da Piercarlo Grimaldi, Davide Porporato e Gianpaolo Fassino. La regia dei documentari audiovisivi è di Stefano Cavallotto, Andrea Icardi, Luca Ghiardo, Dario Leone e Luca Percivalle
« Il nuovo corso della poesia. Osservazioni sui presupposti linguistici di Appunti per un’Orestiade Africana », Davide Luglio
No full text"Il nuovo corso della poesia. Osservazioni sui presupposti linguistici di Appunti per un’Orestiade Africana", communication de Davide Luglio au Colloque international : « Jenseits europas. Pasolini und das abendländische erbe / oltre l’europa: Pasolini e l’eredità occidentale », organisé par le Berlin Institute for Cultural Inquiry, Villa Vigoni-Centro Italo-Tedesco per l’Eccellenza Europea, 31 mars-3 avril 2011. Programme du colloque Site du colloque : http://pasolini.jenseits.ici-berlin.org..
Davide Montino, the thinker and the man
No full textL'autore traccia una dettagliata biografia professionale e scientifica dello storico dell'educazione Davide Montino, descrivendone il percorso formativo, quello professionale e le principali linee di ricerca da esso percorse nel corso della sua breve ma intensa attività accademica
Nota dei curatori
No full textIl volume è l’esito di alcune riflessioni dei professori titolari delle cattedre dei corsi di Laboratorio di composizione architettonica e urbana, prof. R. Capozzi, prof.ssa P. Scala, prof.ssa V. Pezza, Prof. G. Szaniszlò, e delle relative esperienze didattiche svolte nei corsi di laboratorio al primo anno del CdL ARC5UE, a.a. 2020/2021, presso il Dip. di Architettura dell’Università degli studi di Napoli Federico II; ed infine restituisce le lectiones di docenti esterni al DiARC invitati al ciclo di seminari svolto a corsi congiunti.
Il volume si suddivide in tre parti: Parte I - Il progetto didattico tra teoria e laboratori, Parte II - Le esperienze di laboratorio, Parte III - Architettura, città e archeologia.
A curare il volume sono stati l’arch. Francesca Spacagna, referente del corso 1 A; l’arch. phd candidate Maria Fierro, referente del corso 1 B; l’arch. Davide Apicella, referente del corso 1 C; l’arch. Pasquale Abbagnale, referente del corso 1 D
The stress concentration near a rigid line inclusion in a pre-stressed, elastic material. Part II - Implications on shear band nucleation, growth and energy release rate
No full textThe full-field and asymptotic solutions derived in Part I of this article (for a lamellar rigid inclusion, embedded in a uniformly prestressed, incompressible and orthotropic elastic sheet, subject to a far-field deformation increment) are employed to analyse shear band formation, as promoted by the near-tip stress singularity. Since these solutions involve the prestress as a parameter, stress and deformation fields can be investigated near the boundary of ellipticity loss (but still within the elliptic range). In the vicinity of this boundary, the incremental stress and displacement fields evidence localized deformations with patterns organized into shear bands, evidencing inclinations corresponding to those predicted at ellipticity loss. These localized deformation patterns are shown to explain experimental results on highly deformed soft materials containing thin, stiff inclusions. Finally, the incremental energy release rate and incremental J-integral are
derived, related to a reduction (or growth) of the stiffener. It is shown that this is always positive (or negative), but tends to
zero approaching the Ellipticity boundary, which implies that reduction of the lamellar inclusion dies out and, simultaneously, shear bands develop
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