5,673 research outputs found
School of Batman - David Graeber
No full textThis week, we're unpicking the societal and anthropological tones in the Nolan Batman trilogy with our special guest, David Graeber!David is currently Professor of Anthropology at the London School of Economics with a Masters and Doctorate from the University of Chicago. He is an award-winning author of many works including "The Democracy Project", “Bullshit Jobs”, and "Debt: The First 5,000 Years".You can find out more about David on Twitter at https://twitter.com/davidgraeber.__________________Impact Moderato by Kevin MacLeod is licensed under a Creative Commons Attribution license (creativecommons.org/licenses/by/4.0/)Source: incompetech.com/music/royalty-fre…isrc=USUAN1100618Artist: incompetech.com/</div
The fate of levodopa in rats and man
No full textAlthough levodopa was introduced almost 30 years ago it still represents the first-choice treatment of Parkinson's disease. However, during long-term administration of the drug approximately 50% of patients suffer from unwanted side-effects such as end-of-dose deterioration or the `on-off' phenomenon. These side effects have been reported to be due to the pharmacokinetics and/or pharmacodynamics of the drug which are complex and at the present time not fully understood. Levodopa has been reported to be absorbed across the intestine by a saturable, active transport system used by other large neutral amino acids and known as the LNAA transport system. Evidence to support this was provided by experiments with inverted segments of rat intestine in-vitro. Uptake of levodopa by the segments was significantly reduced by rendering the tissues anoxic by gassing with N2, in the presence of the large neutral amino acids L-leucine, L-phenylalanine and by the metabolic inhibitor cyanide. The use of inverted gut sacs and isolated brush border membrane vesicles did not prove satisfactory for measuring the active transport system of levodopa absorption. Covalent binding of the drug occurred with the isolated brush border membrane vesicle preparations. Large individual and regional differences were observed in the L-aromatic amino acid decarboxylase (L-AAAD) activity of the rat stomach and intestine in-vitro. Furthermore, large individual differences in L-AAAD activity were observed in biopsy samples obtained from the human gastric and duodenal mucosae. These findings may explain the large individual differences in plasma concentrations often seen following oral administration of levodopa. In addition, the gut flora were found to be capable of extensive metabolism of levodopa. Age was found to be an important determinant of the pharmacokinetics of levodopa when given alone or in conjunction with the peripheral decarboxylase inhibitor carbidopa. Systemic clearance in the elderly was significantly lower than in the young, both in the absence and presence of carbidopa. In the absence of carbidopa the absolute oral bioavailability of levodopa, as assessed by an oral/IV comparison in young and elderly healthy volunteers, was found to be 63% in the elderly, significantly higher than that in the young (41%). In the presence of the decarboxylase inhibitor the age-related difference was abolished, the bioavailability in both groups increasing to 85% and 86% in elderly and young respectively. Levodopa inhibited gastric emptying in young healthy volunteers and resulted in the presence of multiple peaks following oral administration of the drug. Altered gastric emptying may be extremely important in patients suffering from the `on-off' phenomenon because such patients appear to be dependent on constant plasma levels of the drug. (DX88275)</p
The Palgrave Handbook of Critical Music Industry Studies
No full textThe Handbook of Critical Music Industry Studies provides students and researchers with the means to think about how the performance, recording, and publishing of music could be if we do things differently. People are hungry for a more equitable music performance and recording system. The industry exudes patriarchy, white supremacy, cultural imperialism, ableism, and worker exploitation. In the context of gendered (e.g., #MeToo and #TimesUp) and racialized (e.g., Black Lives Matter) inequity, rampant precarity and casualization, and modes of musical dissemination that are changing faster than policymakers and regulatory bodies can keep up with, the timing for assembling such an interdisciplinary collection could not be more appropriate. Essays in this handbook will tackle power structures at root in the music industry and the academic study of the field. Topics covered include the politics of representation and power in the global music industries, the labor of music, music as media (including data and algorithmic culture), and copyright/intellectual property, among others
Fighting words: Nolan and poetry
No full textCatalogue essay - exploring artist Sidney Nolan's relationship to poetr
[Sitting room with cerise velvet and stripes accenting the colours of a Nolan painting, with tailored pink curtains banded in putty green repeating the tones of the damask wallpaper, ca. 1971] [transparency] /
No full textTitle devised by cataloguer from caption list and information in the publication: Australian decor.; Part of the Warren T. Harding and David C. Lorimer collection of interior design.; Similar image published in: Australian decor / Warren T. Harding [and] David C. Lorimer. Photos by David Beal. [Melbourne] : Nelson, [1971]; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3289971. Photographer David Beal was employed by the firm Decor Associates Pty. Ltd. in whom Warren T. Harding and David C. Lorimer were partners, to photograph homes and business premises they had decorated. Some of these photographs were used in the publication: Australian decor / Warren T. Harding [and] David C. Lorimer. Photos by David Beal. [Melbourne] : Nelson, [1971]
From olefin metathesis to organoruthenium homogeneous catalysis : synthesis, applications and mechanistic understanding
No full textOlefin metathesis is a valuable synthetic tool, widely used in several fields of science. Due to the importance of this transformation several contributions have been made in this field in order to understand mechanistic aspects, reactivity and applicability of this process.
In this topic, ruthenium indenylidene complexes have shown great activity and stability in metathesis, making them very valuable pre-catalysts. However, several aspects of these pre-catalysts have not been evaluated yet. For example, even though reports of active second generation ruthenium indenylidene complexes bearing bulky N-heterocyclic carbenes are present in the literature, no studies have been done to understand how steric hindrance affects the process. For these reasons, [RuCl₂(IPr*)(PPh₃)(3-phenylindenylidene)] (IPr*-PPh₃) and [RuCl₂(IPr*)(Py)(3-phenylindenylidene)] (IPr*-Py), bearing the very bulky ligand, IPr* have been synthesised and compared with [RuCl₂(IPr)(PPh₃)(3-phenylindenylidene)] (IPr-PPh₃) and the new [RuCl₂(IPr)(Py)(3-phenylindenylidene)] (IPr-Py).
Another important aspect, presented in this thesis, is the investigation of the stability of indenylidene pre-catalysts in alcohol solvents. Surprisingly, several different decomposition processes occur depending on the starting complex and the alcohol used. Mechanistic investigation into this decomposition, allowed us to develop a better understanding of this process, and to predict the decomposition product based on the environment. In particular, this study revealed that [RuCl(η⁵-3-phenylindenyl)(PPh₃)₂] (Eta-5) is accessed from [RuCl₂(3-phenylindenylidene)(PPh₃)₂] (M₁₀) via a novel indenylidene to η⁵-indenyl rearrangement. This formal decomposition product has been found to be active in at least 20 different catalytic transformations, rendering it a versatile catalytic tool
The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
No full textRecent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms. The anti-CD20 monoclonal antibody, Rituximab, has resulted indramatic improvements in survival for patients with B cell Non Hodgkin’slymphoma. Histone deacetylase inhibitors are a novel class of anti canceragents targeting epigenetic regulation.This thesis addresses the interaction between histone deacetylase inhibitorsand anti-CD20 monoclonal antibodies, including Rituximab, both in vitro andin vivo. The initial approach identified synergistic induction of apoptosis in anumber of B cell lines. In a Ramos xenograft model, combination treatmentwith suberoylanilide hydroxamic acid (SAHA) and Rituximab reduced tumourgrowth compared to either agent alone, without discernable toxicity. Thiseffect appears specific to CD20 since monoclonal antibodies directed to othersurface molecules (CD32b, CD22, CD37) did not exhibit cooperative effect.Analysis of apoptotic pathways demonstrated that PARP cleavage andcaspase processing is significantly higher in cells receiving both treatments.Co-treatment of Ramos cells with the pan caspase inhibitor QVD-OPHabolished the synergy observed with CD20 monoclonal antibodies,suggesting that caspase processing is necessary for synergy. Treatment ofRamos cells stably transfected to overexpress Bcl-2 resulted in loss ofsynergy with Rituximab, but not with the type II CD20 mAb B1 (Tositumomab).Gene expression array analysis of Ramos cells was performed. Genesetenrichment analysis identified significant regulation of NF?B target genes insome genesets (Rituximab Vs control, p<0.001) with a number associatedwith apoptosis and B cell activation (Bcl2A1, LTA, CD69) which wereconfirmed using RT-Q-PCR.This novel combination elicits the induction of apoptosis in vitro, potentiallythrough regulation of Bcl-2 family proteins and should be tested in a phaseI/II clinical trial
Magic Money
No full textTo dear Arne Nixon Leo PolitiInscription to Arne Nixon on title page verso. Includes signature by author Ann Nolan Clark. A butterfly and flowers frame the inscription
[Handwritten note concerning Jack Ruby and Nolan Ray Schaffer]
No full textHandwritten note by an unknown author concerning Jack Ruby and Nolan Ray Schaffer
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