525 research outputs found
Presenting Norma Fox Mazer
No full textA critical study of a popular author and her work, which has been influential in the field of realistic fiction for young adults
The Contractor
No full textNovember 30 - December 4 and December 7 - 11, 1977. University Theatre Viertes Haus 100. Written by David Storey. Directed by Judith Edwards. Set design by Paul Mazer. Costume Design by Jo-Dee Mercurio. Starring Alfredo Alvarez-Calderon as Kay; Bob Kranz as Marshall; Don Harthcock as Ewbank; Andy Garcia as Glendenning.https://digitalcommons.fiu.edu/theatre_programs/1093/thumbnail.jp
Andy Garcia, Wein and Ciotta in The Contractor
No full textViertes Haus 100. November 30 - December4 and December 7 - 11, 1977. Written by David Storey. Directed by Judith Edwards. Costume design by Jo-Dee Mercurio. Set design by H. Paul Mazer. Starring Alfredo Alvarez-Calderon as Kay; Bob Kranz as Marshall; Don Harthcock as Ewbank; Andy Garcia as Old Ewbank
Pictured left to right Andy Garcia, Wein and Ciottahttps://digitalcommons.fiu.edu/theatre_images/1597/thumbnail.jp
Bob Kranz and Wein in The Contractor
No full textViertes Haus 100. November 30 - December4 and December 7 - 11, 1977. Written by David Storey. Directed by Judith Edwards. Costume design by Jo-Dee Mercurio. Set design by H. Paul Mazer. Starring Alfredo Alvarez-Calderon as Kay; Bob Kranz as Marshall; Don Harthcock as Ewbank; Andy Garcia as Old Ewbank
Pictured left to right Bob Kranz and Weinhttps://digitalcommons.fiu.edu/theatre_images/1598/thumbnail.jp
A Large Water Diuresis during Hypoxia: Intervention with dDAVP and Furosemide
No full textAcute kidney injury (AKI) is associated with renal medullary hypoxia. The medullary thick ascending limb (mTAL) in the renal outer medulla is most susceptible to hypoxic injury, due to marginal O2 supply and high O2 consumption. The objectives of this study were to document the earliest effect of hypoxia (8% O2 for 2.5 hrs) on the mTAL function, and to identify strategies to protect the mTAL from hypoxia. The earliest effect of hypoxia is large water diuresis, due to a fall in the medullary osmolality and increase in vasopressinase. Desmopressin acetate (dDAVP), a synthetic vasopressin analogue resistant to vasopressinase that may also increase O2 delivery, prevented water diuresis. A low dose (0.8mg/kg) of furosemide may significantly reduce the mTAL work without a large excretion of essential electrolytes. Large water diuresis may be diagnostically valuable in detecting renal tissue hypoxia, and dDAVP and furosemide may prevent AKI in the clinical setting.MAS
Impact of sex determination and preoperative anemia in cardiac surgery: A secondary analysis from the Transfusion Requirements in Cardiac Surgery (TRICS) III trial
No full textRed blood cell (RBC) transfusions are used to correct intraoperative anemia, despite their associations with morbidity and mortality. Women and preoperatively anemic patients remain underrepresented in cardiac research. Using TRICS III trial data, we constructed logistic regression models of propensity-score matched cohorts to investigate the impact of female sex and preoperative anemia on transfusion and clinical outcomes in cardiac surgery, hypothesizing associations between both factors and worse outcomes. Both sex-dependent and sex-independent anemia definitions were assessed. Female sex was associated with increased RBC transfusion but reduced risk of renal complications, whereas preoperative anemia was associated with increased RBC transfusion, death, and renal dysfunction. Borderline anemic women excluded by the sex-dependent anemia definition faced similar risks as increasingly anemic women, supporting the adoption of sex-independent thresholds in cardiac surgery. Female and preoperatively anemic patients were also at higher risk of protocol-deviant transfusion, suggesting potential caregiver bias when making perioperative transfusion decisions.M.Sc
A Large Water Diuresis during Hypoxia: Intervention with dDAVP and Furosemide
No full textAcute kidney injury (AKI) is associated with renal medullary hypoxia. The medullary thick ascending limb (mTAL) in the renal outer medulla is most susceptible to hypoxic injury, due to marginal O2 supply and high O2 consumption. The objectives of this study were to document the earliest effect of hypoxia (8% O2 for 2.5 hrs) on the mTAL function, and to identify strategies to protect the mTAL from hypoxia. The earliest effect of hypoxia is large water diuresis, due to a fall in the medullary osmolality and increase in vasopressinase. Desmopressin acetate (dDAVP), a synthetic vasopressin analogue resistant to vasopressinase that may also increase O2 delivery, prevented water diuresis. A low dose (0.8mg/kg) of furosemide may significantly reduce the mTAL work without a large excretion of essential electrolytes. Large water diuresis may be diagnostically valuable in detecting renal tissue hypoxia, and dDAVP and furosemide may prevent AKI in the clinical setting.MAS
Evaluation of Strategies for Managing Anemia and Transfusion in Cardiac Surgery and Risk Factors for Cardiovascular Health
No full textPatients with high cardiovascular risk may develop coronary artery disease requiring surgical intervention. The primary focus of this thesis was to evaluate strategies for reducing the potential risks associated with anemia in cardiac surgical patients. A secondary focus of this thesis was to explore the potential cardiovascular risks associated with cannabis in young adults. The first study was a subset analysis of the Transfusion Thresholds in Cardiac Surgery (TRICS-III) trial evaluating transfusion thresholds in patients with acute myocardial infarction on long-term cardiovascular outcomes, and a synthesis of the results with all available evidence through a systematic review and meta-analysis. We identified that liberal transfusion strategies may reduce the risk for long-term major adverse cardiovascular events.
The second study was a subgroup analysis of the TRICS-III trial evaluating transfusion thresholds in patients with diabetes undergoing cardiac surgery. Despite patients with diabetes having increased cardiovascular risk, restrictive transfusion did not increase the risk for clinical outcomes and was more effective at reducing transfusion.
The third study was a translational study of the TRICS-III trial evaluating the role of plasma methemoglobin as a marker for anemia-induced tissue hypoxia. Reductions in hemoglobin were associated with increases in methemoglobin, and elevated post-surgical methemoglobin was associated with an increased risk for neurological outcomes.
The fourth study was a cross-sectional analysis of the nationally representative Behavioral Risk Factor Surveillance System survey to evaluate the association between recent cannabis use and myocardial infarction in young adults. Recent cannabis use was associated with a 2-fold increase in the risk for myocardial infarction. This risk was elevated in more frequent users of cannabis, and was sustained across all methods of consumption.
We demonstrated that there may be differences in the susceptibility of anemia and tolerance to transfusion in specific subgroups of patients with high cardiovascular risk undergoing cardiac surgery, and incorporation of a biological marker of anemic stress may better inform clinical decision making for personalizing transfusion therapy for improving postoperative clinical outcomes and reducing unnecessary exposure to banked blood. Additionally, insights from our cross-sectional study may inform individual decision making regarding an underappreciated cardiovascular risk associated with cannabis use.Ph.D
Ideology or Experience? The Relationships Among Perceptions, Attitudes, and Experiences of Sexual Harassment in University Students
No full textRelationships among sexual harassment experiences, perceptions about harassment (definitions, seriousness ratings, commonness estimates), and attitudes (about both harassment and sex roles) were examined in order to investigate the role of ideology and consciousness in the reporting of sexual harassment experiences. University students responding to a survey were divided by sex (74 males, 136 females) and level of harassment experience (high, moderate, low) in a 3 × 2 factorial design. Results indicated that high experiencers estimated that sexual harassment was made common among other students than those with less experience. Other perceptual variables and attitudes were unrelated to experience level. Significant sex differences were present for definitions, for the Sexual Harassment Attitude Scale, and for the Macho Scale. Significant relationships were also present among definitions, seriousness ratings, and the two attitude measures. Results suggest that reporting experiences of harassment appears relatively independent of ideology or a sensitized consciousness. Implications for issues of representativeness of samples in harassment survey research are discussed
Mechanisms that Jeopardize Skeletal Muscle Perfusion during Surgery
No full textWe assessed potential mechanisms that may jeopardize skeletal muscle perfusion during surgery leading to adverse outcomes including muscle injury and flap hypoxia. In craniotomy patients, we observed an increase in serum lactate and creatine kinase and urine myoglobin; indicative of muscle damage. The early rise in lactate correlated with elevated BMI, suggesting that obesity caused tissue compression and muscle ischemia. In our rodent model, we investigated the effects of flap preparation and phenylephrine on muscle perfusion by assessing microvascular blood flow and tissue PO2. Phenylephrine reduced muscle blood flow by ~20%, yet increased PO2 by ~10% suggestive of decreased O2 metabolism. At baseline, muscle flap blood flow was reduced by ~50% while PO2 was severely reduced ~80% (~5 torr) suggesting that flap perfusion was attenuated and O2 metabolism was increased. Phenylephrine infusion further reduced muscle flap perfusion. These data demonstrate multiple mechanisms by which muscle perfusion is jeopardized during surgery.MAS
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