1,289 research outputs found
Statistical aspects of clinical trials
No full textThis thesis presents a book and a collection of published papers concerned with statistical aspects of clinical trials. It is divided into six chapters emphasising design, the protocol, quality control, analysis, prognosis and statistical theory.3OCThe design section is mainly concerned with the estimation of patient numbers required for a randomised trial in order to detect a pre-specified clinically worthwhile difference between treatments for a given test size and power. It includes corresponding tables for sample sizes.Several examples of summary protocols and papers on organisational, data management and analysis aspects of clinical trials are included. Two papers describe the evolution of checklists for the assessment of the statistical quality of the design of clinical studies and their reporting.The results of cancer therapy trials, the effect of ultrasound on pressure sores, the evaluation of health education material and compliance with screening for colorectal cancer are described. Particular emphasis is placed on randomised trials of alternative therapies, including acupuncture and transcutaneous nerve stimulation, for the relief of chronic pain. The majority of these latter trials failed to achieve anticipated pre-trial efficacy for the active treatmentPrognostic factors are identified for gastro-intestinal lymphoma, the myelodysplastic syndromes and low back pain and sciatica.Theoretical papers describing the advantages of multi-centre as opposed to single centre trials, the possibility of incorporating non-randomised patients into a randomised trial, estimating the proportion of cured patients in cancer trials and the extension of a decision theoretic model for selecting medical treatments as an alternative to the classical randomised control trial are presented.</p
Correspondence with University of Southern California and William Heinemann Publishers December 1963 - March 1964
No full textCorrespondence between Fayez Sayegh and Willard Beling of University of Southern California regarding the possibility of an opening at the University; and letters between Sayegh and David Machin of William Heinemann Publishers about the possibility of publishing Sayegh\u27s book on President Nasser\u27s Understanding of Socialism
Finding and Excluding <i>b</i>-ary Machin-Type Individual Digit Formulae
No full textAbstractConstants with formulae of the form treated by D. Bailey, P. Borwein, and S. Plouffe (BBP formulae to a given base b) have interesting computational properties, such as allowing single digits in their base b expansion to be independently computed, and there are hints that they should be normal numbers, i.e., that their base b digits are randomly distributed. We study a formally limited subset of BBP formulae, which we call Machin-type BBP formulae, for which it is relatively easy to determine whether or not a given constant κ has a Machin-type BBP formula. In particular, given b ∈ ℕ, b > 2, b not a proper power, a b-ary Machin-type BBP arctangent formula for κ is a formula of the form κ = Σmam arctan(–b–m), am ∈ ℚ, while when b = 2, we also allow terms of the form am arctan(1/(1 – 2m)). Of particular interest, we show that π has no Machin-type BBP arctangent formula when b ≠ 2. To the best of our knowledge, when there is no Machin-type BBP formula for a constant then no BBP formula of any form is known for that constant.</jats:p
Unions and Procedural Justice: An Alternative to the Common Rule
No full textCan unions substitute a procedural justice role for their traditional reliance on establishing a¿common rule¿? The decline of ¿bureaucratic¿ models of employee management and the riseof performance pay and performance management conflicts with the common rule asmanagement seek to tie rewards more closely to individual and organisational performance.CEP studies of performance pay in the British public services illustrate the potential for aprocedural justice role to ensure that such pay systems are operated fairly, otherwise they riskdemotivating staff. Evidence is presented to show that employees regard unions as effectivevehicles for procedural justice. In this way, management can achieve better operation of theirincentive schemes, and employees may experience less unfairness and poisoned workrelations.performance-related pay, public services, procedural justice, management
Machin la Hernie : théâtre monstre: avant-propos
No full textInternational audienceThe writing of Machin la Hernie, the novel by Congolese writer Sony Labou Tansi (1947-1995) directed by Jean-Paul Delore and performed by Dieudonné Niangouna, is partly inspired by the radio speeches of General Mobutu, the dictator who ruled the Democratic Republic of Congo. "Sony Labou Tansi" is a pseudonym for Marcel N'soni, which the author belatedly fixed after having known numerous versions (see Céline GAHUNGU, Sony Labou Tansi. Naissance d'un écrivain, CNRS éditions, 2019, p. 31-34). "Sony" is a spelling transformation of "N'soni" ("my shame"), the birth name given to the author by his father out of bitterness at having been spurned by the woman with whom he would have preferred to have a child. In a letter to Nicolas Martin-Granel in 1994, however, the writer gave another meaning to "Sony": "la pudeur" ("modesty"). Labou is his father's name (Paul Labou), or rather his nickname (a "labou" is a dancing instrument). By homophony, it is also "the mud" with which or in which the writer says he works. "Tansi" ("the earth", or "the country") is an evocation of Sony's grandmother (his "first wife" among the Kongo), Luttunu Bana Tansi ("they left with the earth"), and a tribute to the great Congolese writer U Tam'si.L'écriture fleuve de Machin la Hernie, le roman de l'écrivain congolais Sony Labou Tansi (1947-1995) mis en scène par Jean-Paul Delore et interprété par Dieudonné Niangouna, est en partie inspirée par les discours radiophoniques du général Mobutu, le dictateur qui a gouverné la République Démocratique du Congo « Sony Labou Tansi » est un pseudonyme de Marcel N'soni fixé tardivement par l'auteur après avoir connu de nombreuses versions (voir Céline GAHUNGU, Sony Labou Tansi. Naissance d'un écrivain, CNRS éditions, 2019, p. 31-34). « Sony » est une transformation orthographique de « N'soni » (« ma honte »), le nom de naissance donné par son père à l'auteur par amertume d'avoir été éconduit par la femme avec laquelle il aurait préféré avoir un enfant. Dans une lettre adressée à Nicolas Martin-Granel en 1994, l'écrivain donnera toutefois un autre sens à « Sony » : « la pudeur ». Labou est le nom de son père (Paul Labou), ou plutôt son sobriquet (un « labou » est un instrument de danse). Par homophonie, c'est aussi « la boue » avec laquelle ou dans laquelle l'écrivain dit travailler. « Tansi » (« la terre », ou « le pays ») est une évocation de la grand-mère de Sony (sa « première femme » chez les Kongo), Luttunu Bana Tansi (« ils sont partis avec la terre »), et un hommage au grand écrivain congolais U Tam'si
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