490 research outputs found
Lythgoe, David. Interview about the restoration of the Admiralty House Museum, Mount Pearl.
No full textInteview with David Francis Joseph Lythgoe about the restoration of the Admiralty House, Mount Pearl, and its conversion into a museum. David talks about the origins of the Lythgoe family name; growing up in Rabbittown, St. John's; his grandfather arriving in Newfoundland and studying to become a Methodist minister; how David got involved with the restoration of the Admiralty House as a neighbour; the condition of the building circa 1995-1997; the carpenter who worked on the building; the grounds surrounding the building; the volunteers involved; a visit from the Phillip, the Duke of Edinburgh on 23 June 1997; the beams in the building; the use of the building as a spy station to monitor U-Boats; the Calypso and the Navy; changes to the building; SONRA (Society of Newfoundland Radio Amateurs); development of the board of directors; the SS Florizel exhibit and its link to the building; weddings on the site; the importance of having passion for heritage and history
Nubian a-group and Egyptian Naqada trade relations in the predynastic
No full textThe archaeological study of interregional trade provides the unique opportunity to reconstruct not only the foreign relations of cultures that are no longer in existence, but also how these relations evolved over extended periods of time. This study examines interactions between the Egyptian Naqada and Nubian A-Group cultures - located near the present day border of Egypt and The Sudan - between 3800 and 2900 B.C.E. Cemeteries from each group were compared looking at frequency of grave goods, burial architecture, the treatment of the deceased, and how these factors changed over time, in order to determine: (a) the degree of social complexity in Nubian A-Group society, and (b) the ability of trade to influence culture. The study found that while Nubian A-Group society shows some signs of social complexity, the A-Group culture was not nearly as complex as the near state-level society seen with the Egyptian Naqada culture. In line with this, the study found that there was a disproportionate level of cultural influence between the two groups, with the Nubian A-Group culture adopting many Egyptian traits
Book Launch | Dimitri Van Den Meerssche's The World Bank's Lawyers
No full textOn Wednesday 16 November, the ESIL Interest Groups on History of Intentional Law and International Organisations and Völkerrechtsblog, hosted a book launch for The World Bank’s Lawyers by Dr. Dimitri van den Meerssche (Queen Mary University London).In addition to hearing from the author, discussants included Negar Mansouri (Graduate Institute of International and Development Studies), Dr Gail Lythgoe (University of Manchester), Dr. Tommaso Soave (Central European University) and Dr. Ahmed Memon (Cardiff School of Law and Politics). Florenz Volkaert (Ghent University) moderated.<br/
Book Launch | Dimitri Van Den Meerssche's The World Bank's Lawyers
No full textOn Wednesday 16 November, the ESIL Interest Groups on History of Intentional Law and International Organisations and Völkerrechtsblog, hosted a book launch for The World Bank’s Lawyers by Dr. Dimitri van den Meerssche (Queen Mary University London).In addition to hearing from the author, discussants included Negar Mansouri (Graduate Institute of International and Development Studies), Dr Gail Lythgoe (University of Manchester), Dr. Tommaso Soave (Central European University) and Dr. Ahmed Memon (Cardiff School of Law and Politics). Florenz Volkaert (Ghent University) moderated.<br/
Book Launch | Dimitri Van Den Meerssche's The World Bank's Lawyers
No full textOn Wednesday 16 November, the ESIL Interest Groups on History of Intentional Law and International Organisations and Völkerrechtsblog, hosted a book launch for The World Bank’s Lawyers by Dr. Dimitri van den Meerssche (Queen Mary University London).In addition to hearing from the author, discussants included Negar Mansouri (Graduate Institute of International and Development Studies), Dr Gail Lythgoe (University of Manchester), Dr. Tommaso Soave (Central European University) and Dr. Ahmed Memon (Cardiff School of Law and Politics). Florenz Volkaert (Ghent University) moderated.<br/
Differential sensitivity to the acute psychotomimetic effects of delta-9-tetrahydrocannabinol associated with its differential acute effects on glial function and cortisol
No full textBackground: Cannabis use has been associated with psychosis through exposure to delta-9-tetrahydrocannabinol (Δ9-THC), its key psychoactive ingredient. Although preclinical and human evidence suggests that Δ9-THC acutely modulates glial function and hypothalamic-pituitary-adrenal (HPA) axis activity, whether differential sensitivity to the acute psychotomimetic effects of Δ9-THC is associated with differential effects of Δ9-THC on glial function and HPA-axis response has never been tested. Methods: A double-blind, randomized, placebo-controlled, crossover study investigated whether sensitivity to the psychotomimetic effects of Δ9-THC moderates the acute effects of a single Δ9-THC dose (1.19 mg/2 ml) on myo-inositol levels, a surrogate marker of glia, in the Anterior Cingulate Cortex (ACC), and circadian cortisol levels, the key neuroendocrine marker of the HPA-axis, in a set of 16 healthy participants (seven males) with modest previous cannabis exposure. Results: The Δ9-THC-induced change in ACC myo-inositol levels differed significantly between those sensitive to (Δ9-THC minus placebo; M = -0.251, s.d. = 1.242) and those not sensitive (M = 1.615, s.d. = 1.753) to the psychotomimetic effects of the drug (t(14) = 2.459, p = 0.028). Further, the Δ9-THC-induced change in cortisol levels over the study period (baseline minus 2.5 h post-drug injection) differed significantly between those sensitive to (Δ9-THC minus placebo; M = -275.4, s.d. = 207.519) and those not sensitive (M = 74.2, s.d. = 209.281) to the psychotomimetic effects of the drug (t(13) = 3.068, p = 0.009). Specifically, Δ9-THC exposure lowered ACC myo-inositol levels and disrupted the physiological diurnal cortisol decrease only in those subjects developing transient psychosis-like symptoms. Conclusions: The interindividual differences in transient psychosis-like effects of Δ9-THC are the result of its differential impact on glial function and stress response
Association between cannabinoid 1 receptor availability and glutamate levels in healthy controls and drug-free patients with first episode psychosis
No full textCannabinoid 1 receptor and glutamatergic dysfunction have both been implicated in the pathophysiology of schizophrenia. However, it remains unclear if cannabinoid 1 receptor alterations shown in drug-naïve/free patients with first episode psychosis may be linked to glutamatergic alterations in the illness. We aimed to investigate glutamate levels and cannabinoid 1 receptor levels in the same region in patients with first episode psychosis. Forty volunteers (20 healthy volunteers, 20 drug-naïve/free patients with first episode psychosis diagnosed with schizophrenia/schizoaffective disorder) were included in the study. Glutamate levels were measured using proton magnetic resonance spectroscopy. CB1R availability was indexed using the distribution volume (VT (ml/cm3)) of [11C]MePPEP using arterial blood sampling. There were no significant associations between ACC CB1R levels and ACC glutamate levels in controls (R = − 0.24, p = 0.32) or patients (R = − 0.10, p = 0.25). However, ACC glutamate levels were negatively associated with CB1R availability in the striatum (R = − 0.50, p = 0.02) and hippocampus (R = − 0.50, p = 0.042) in controls, but these associations were not observed in patients (p > 0.05). Our findings extend our previous work in an overlapping sample to show, for the first time as far as we’re aware, that cannabinoid 1 receptor alterations in the anterior cingulate cortex are shown in the absence of glutamatergic dysfunction in the same region, and indicate potential interactions between glutamatergic signalling in the anterior cingulate cortex and the endocannabinoid system in the striatum and hippocampus
sj-docx-1-jop-10.1177_02698811231168243 – Supplemental material for Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus
No full textSupplemental material, sj-docx-1-jop-10.1177_02698811231168243 for Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus by Piril Hepsomali, Sandra Machon, Holly Barker, David J Lythgoe, Kenneth Hugdahl, Maria Gudbrandsen and Paul Allen in Journal of Psychopharmacology</p
Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis
No full textThe neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects either acute or chronic striatal dopamine is inconclusive. In contrast, pre-clinical research suggests that cannabis may affect dopamine via modulation of glutamate signaling. A double-blind, randomized, placebo-controlled, crossover design was used to investigate whether altered striatal glutamate, as measured using proton magnetic resonance spectroscopy, underlies the acute psychotomimetic effects of intravenously administered delta-9-tetrahydrocannabinol (Δ9-THC; 1.19 mg/2 ml), the key psychoactive ingredient in cannabis, in a set of 16 healthy participants (7 males) with modest previous cannabis exposure. Compared to placebo, acute administration of Δ9-THC significantly increased Glutamate (Glu) + Glutamine (Gln) metabolites (Glx) in the left caudate head (P = 0.027). Furthermore, compared to individuals who were not sensitive to the psychotomimetic effects of Δ9-THC, individuals who developed transient psychotic-like symptoms (~70% of the sample) had significantly lower baseline Glx (placebo; P 7= 0.023) and a 2.27-times higher increase following Δ9-THC administration. Lower baseline Glx values (r = -0.55; P = 0.026) and higher previous cannabis exposure (r = 0.52; P = 0.040) were associated with a higher Δ9-THC-induced Glx increase. These results suggest that an increase in striatal glutamate levels may underlie acute cannabis-induced psychosis while lower baseline levels may be a marker of greater sensitivity to its acute psychotomimetic effects and may have important public health implications
sj-pdf-1-jcb-10.1177_0271678X231157958 - Supplemental material for The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats
No full textSupplemental material, sj-pdf-1-jcb-10.1177_0271678X231157958 for The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats by Nisha Singh, Eilidh MacNicol, Ottavia DiPasquale, Karen Randall, David Lythgoe, Ndabezinhle Mazibuko, Camilla Simmons, Pierluigi Selvaggi, Stephanie Stephenson, Federico E Turkheimer, Diana Cash, Fernando Zelaya and Alessandro Colasanti in Journal of Cerebral Blood Flow & Metabolism</p
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