335 research outputs found
sj-pdf-1-smm-10.1177_09622802211013578 - Supplemental material for A permutation-based approach to inference for weighted sum regression with correlated chemical mixtures
No full textSupplemental material, sj-pdf-1-smm-10.1177_09622802211013578 for A permutation-based approach to inference for weighted sum regression with correlated chemical mixtures by Grace R Lyden, David M Vock, Emily S Barrett, Sheela Sathyanarayana, Shanna H Swan and Ruby HN Nguyen in Statistical Methods in Medical Research</p
Immunotherapy
No full textA chapter covering metastasis immunotherapy in multi-author volume devoted to all aspects of cancer metastasis
Thrombolysis is associated with consistent functional improvement across baseline stroke severity: a comparison of outcomes in patients from the Virtual International Stroke Trials Archive (VISTA)
No full text<p><b>Background and Purpose:</b> Baseline stroke severity predicts outcomes among thrombolysed patients. The baseline National Institutes of Health Stroke Scale (NIHSS) thresholds are sometimes used to select patients for thrombolysis, clinical trial enrollment, or both. Using data lodged with Virtual International Stroke Trials Archive, we compared adjusted outcomes between thrombolysed and nonthrombolysed patients enrolled in neuroprotection trials (1998-2007) to assess the influence of various levels of baseline NIHSS.</p>
<p><b>Method:</b> We assessed the association of treatment with outcome, measured across the modified Rankin scale score distribution, in patients categorized by baseline NIHSS in increments of 4. We used an age and baseline NIHSS adjusted Cochran-Mantel-Haenszel test followed by proportional odds logistic regression analysis. We report the Cochran-Mantel-Haenszel P values and estimated odds ratios (OR) for improved modified Rankin scale score distribution with treatment for patients within each baseline NIHSS category.</p>
<p><b>Results:</b> Data were available for 5817 patients (1585 thrombolysed and 4232 nonthrombolysed). Baseline severity was greater among thrombolysed than nonthrombolysed (median baseline NIHSS, 14 vs 13; P<0.05). An association of treatment with outcome was seen independently and was of similar magnitude within each of the baseline NIHSS categories 5 to 8 (P=0.04; OR, 1.25; 95% confidence interval [CI], 1.0-1.6; N=278/934 thrombolysed/nonthrombolysed), 9 to 12 (P=0.01; OR, 1.3; 95% CI, 1.1-1.6; N=404/942), 13 to 16 (P<0.05; OR, 1.6; 95% CI, 1.3-2.1; N=342/814), 17 to 20 (P<0.05; OR, 1.7; 95% CI, 1.3-2.1; N=311/736), and 21 to 24 (P<0.05; OR, 1.6; 95% CI, 1.1-2.1; N=178/466). No association was observed within baseline NIHSS categories 1 to 4 (P=0.8; OR, 1.1; 95% CI, 0.3-4.4; N=8/161) or >= 25 (P=0.08; OR, 1.1; 95% CI, 0.7-1.9; N=64/179).</p>
<p><b>Conclusions:</b> In this nonrandomized comparison, outcomes after thrombolysis were significantly better than in untreated comparators across baseline NIHSS 5 to 24. The significant association was lost only at extremes of baseline NIHSS when sample sizes were small and confidence limits were wide.</p>
'Escaping' from the World Through Film: Theological Perspectives on the 'Real' and the 'Reel'
No full textThe aim of this article is to examine the manner and extent to which the medium of film is capable of comprising a potential site of theological engagement. It takes as its starting point David Jasper's critique of escapism, as outlined in a 1997 chapter, and concludes that film and theology may be brought together as discerning, and reciprocal, dialogue-partners
Hong Kong Medical Forum '97: programme book : 26th-27th July 1997, Hong Kong Convention & Exhibition Centre.
No full textpublished_or_final_versionProgramme - 26th July 1997, Saturday 2Programme - 27th July 1997, Sunday 3Speakers 4Acknowledgment 24AbstractsBrief synopsis of presentation on Klatskin's tumors Pellegrini, Carlos A. Pellegrini, Carlos A. 5Indications for liver transplantation Maddrey, Willis C. Maddrey, Willis C. 6Auxiliary liver transplantation for fulminant hepatic failure Belghiti, Jacques Belghiti, Jacques 8Post-liver transplant medical complications Maddrey, Willis C. Maddrey, Willis C. 9Helicobacter pylori - where do we stand now? Misiewicz, J.J. Misiewicz, J.J. 10Helicobacter pylori and upper gastrointestinal surgery Chu, Kent-man Chu, Kent-man 11Guidelines for the eradication of helicobactor pylori Misiewicz, J.J. Misiewicz, J.J. 12An update on viral hepatitis Maddrey, Willis C. Maddrey, Willis C. 13Thrombolysis for acute stroke Lyden, Patrick D. Lyden, Patrick D. 14Angioplasty and stenting of extracranial cerebral arteries for prevention of strokes Ho, David S.W. Ho, David S.W. 16Acute stroke therapy in Hong Kong Cheung, Raymond T.F. Cheung, Raymond T.F. 17How to run a stroke code Lyden, Patrick D. Lyden, Patrick D. 18Diabetic nephropathy : natural history and therapeutic interventions Lewis, Edmund J. Lewis, Edmund J. 19Pathogenesis and therapeutic interventions in progressive renal diseases Breyer, Julia A. Breyer, Julia A. 20Management of severe lupus nephritis Chan, Daniel T.M. Chan, Daniel T.M. 21Immunotactoid glomerulopathy Lewis, Edmund J. Lewis, Edmund J. 22Renal transplantation : local issues Cheng, Ignatius K.P. Cheng, Ignatius K.P. 2
Huntsville Times sleeve HT0004867
No full textAuthor "Daughter of the Queen of Sheba" / NPR foreign correspondent. / Jackie Lyden / WLRH on UAH [University of Alabama in Huntsville] campus / Author of book being made into major motion picture starring Meryl Streep and Gwyneth Paltrow about living with manic-depressive mom
New data, new doubts: revised 2013
No full textThesis (M.A., Economics) -- California State University, Sacramento, 2013.In 2000, Burnside and Dollar wrote a seminal paper declaring their finding that international economic aid works to increase economic growth in less developed countries where there is good policy. However, in 2003, Easterly, Levine and Roodman, disputed this result, finding the inclusion of additional countries into the sample and a broadening of years covered by the study diminish the robustness of the policy variables??? significance. This thesis will recreate the work of Easterly, Levine and Roodman, and up-date it where they left off in 1997 with the most current data to determine if these results still hold true. Results suggest that policy is in deed significant to growth, irrespective of aid, though the aid-growth relationship is ambiguous, as is any interaction aid and policy have with growth.Economic
Exploring the role of Interleukin-6 and other host-associated factors in tumor progression and metastasis development
No full textABSTRACT: Traditionally, cancer research has had its centre of attention in tumor cells and alterations in their genes, but recently, there has been a shift in focus beyond the tumor cells themselves to the surrounding tumor microenvironment. Specifically, it has become clear that bone-marrow derived cells (BMDCs) play a critical role in metastases development. We demonstrate that IL-6 knockout mice bearing breast or melanoma tumors had a reduction in the number of metastatic foci and metastatic burden as compared to wild-type mice. Analysis of pre-metastatic lungs and blood showed an IL-6 dependent increase in Stat3 activation with CD11b+Gr1+ MDSCs mobilization and recruitment to these sites during metastatic progression. Inducible-ubiquitous overexpression of activated Stat3 increased hematopoietic progenitor cells (Sca1+c-Kit+) and MDSCs in the bone marrow and promoted their mobilization to the lungs, which was abrogated in IL-6 deficient mice. A requirement for bone marrow derived IL-6 for metastasis was determined, as restoration of metastatic growth was observed in IL-6 knockout mice transplanted with wild-type bone marrow. We also demonstrate that in response to IL-6 and TGF-β, upregulation of the Inhibitor of Differentiation 1 (Id1) redirects BMDC differentiation towards Id1-high expressing MDSC with a reciprocal decrease in DC numbers. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumor-derived factors re-creates it. These results reveal a critical role for Id1 in suppressing the anti-tumor immune response during tumor progression. We also explored the role of VEGFR1 expression in BMDCs, and our results clearly demonstrate an important function for VEGFR1-regulated CXCL4 expression by BMDCs in regulating angiogenesis at the primary tumor and metastatic microenvironments. Taken together, our results reinforce the concept of the BMDCs and bone marrow microenvironment as necessary participants in solid-tumor metastasis development.RESUMO: Historicamente, a investigação em cancro centrou-se nas células tumorais e nas alterações genéticas destas células, mas recentemente, tem ocorrido uma mudança de foco para o microambiente tumoral. Especificamente, vários estudos têm demonstrado um papel crítico das células derivadas de medula óssea (BMDCs) no processo de tumorigénese e metastização. Os resultados do nosso trabalho demonstram redução significativa no número de lesões metastáticas pulmonares em ratinhos IL-6 KO com tumores da mama ou melanoma comparativamente com ratinhos wild-type. A análise de sangue e tecido pulmonar em fase pré-metastática mostrou ativação Stat3 dependente de IL-6, com mobilização e recrutamento de MDSCs CD11b + Gr1 + para os futuros órgãos metastáticos. A indução de sobreexpressão de Stat3 resultou num aumento de células hematopoiéticas progenitoras (Sca1 + c-Kit +) e MDSCs na medula óssea, e promoveu a sua mobilização para os pulmões, o que não se verificou em ratinhos IL-6 KO. Nos ratinhos IL-6 KO transplantados com medula óssea wild-type houve recuperação do padrão metastático, o que demonstra o papel importante da IL-6 no processo de metastização. O nosso trabalho também demonstrou que a sobreexpressão de Id1, em resposta a IL-6 ou TGF- β, redireciona a diferenciação de BMDCs no sentido de MDSC com elevada expressão de Id1, com uma diminuição recíproca no número de DCs. Demonstramos ainda que a inactivação genética de Id1 corrige o desequilíbrio mieloide, e que a sobreexpressao de Id1 na ausência de factores tumorais, recria este desequilíbrio. Estes resultados revelam um papel crítico de Id1 na supressão da resposta imune antitumoral
durante o desenvolvimento tumoral. O nosso trabalho explorou ainda o papel da expressão de VEGFR1 em BMDCs, e os nossos resultados demonstram que a expressão de CXCL4 dependente de VEGFR1 pelas BMDCs desempenha uma importante função na regulação da angiogênese do tumor primário e do microambiente metastatico. Globalmente, os nossos resultados reforçam o conceito das BMDCs e do microambiente da medula óssea como participantes necessários no desenvolvimento de metástases de tumores sólidos
New data, new doubts: revised 2013
No full textIn 2000, Burnside and Dollar wrote a seminal paper declaring their finding that international economic aid works to increase economic growth in less developed countries where there is good policy. However, in 2003, Easterly, Levine and Roodman, disputed this result, finding the inclusion of additional countries into the sample and a broadening of years covered by the study diminish the robustness of the policy variables' significance. This thesis will recreate the work of Easterly, Levine and Roodman, and up-date it where they left off in 1997 with the most current data to determine if these results still hold true. Results suggest that policy is in deed significant to growth, irrespective of aid, though the aid-growth relationship is ambiguous, as is any interaction aid and policy have with growth
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