345 research outputs found
Memorials: Vincent H. Arthauld, Kenneth J. Drewry, David L. Mackintosh
No full textVincent H. Arthaud, Professor Emeritus of the Animal Science Department, University of Nebraska, Lincoln, died at his home August 7, 1982. He was born September 7, 1911 at Cambridge, Nebraska and was reared on a general livestock farm in Southwest Nebraska. After receiving his B.S. degree in Animal Husbandry in 1936 from the University of Nebraska, he returned to his home area and engaged in general farming. He served with the U.S. Army from 1942 to 1945 and joined the Animal Science Department in 1945 as Research Farm Manager. He retired in 1977 following his many years of service as a teacher, judging team coach, researcher and business manager for the Animal Sciences Department. Kenneth J, Drewry died September 23, 1981 following a brief illness. David Leslie Mackintosh, an emeritus professor of animal sciences at Kansas State University, Manhattan, and a man internationally known as a teacher and researcher in meats, died April 12, 1982. Mr. Mackintosh, 86, was a member of the Kansas State University faculty from 1921--1965
Memorials: Vincent H. Arthauld, Kenneth J. Drewry, David L. Mackintosh
No full textVincent H. Arthaud, Professor Emeritus of the Animal Science Department, University of Nebraska, Lincoln, died at his home August 7, 1982. He was born September 7, 1911 at Cambridge, Nebraska and was reared on a general livestock farm in Southwest Nebraska. After receiving his B.S. degree in Animal Husbandry in 1936 from the University of Nebraska, he returned to his home area and engaged in general farming. He served with the U.S. Army from 1942 to 1945 and joined the Animal Science Department in 1945 as Research Farm Manager. He retired in 1977 following his many years of service as a teacher, judging team coach, researcher and business manager for the Animal Sciences Department. Kenneth J, Drewry died September 23, 1981 following a brief illness. David Leslie Mackintosh, an emeritus professor of animal sciences at Kansas State University, Manhattan, and a man internationally known as a teacher and researcher in meats, died April 12, 1982. Mr. Mackintosh, 86, was a member of the Kansas State University faculty from 1921--1965
Cadet group from the early 1890's
No full textCadet group. Top row, right to left: David B. Drewry, Wallace C. O. Varner. Bottom row, right to left: John W. Board; unidentified. All those identified were members of the Class of 1893
Design and Synthesis of Small-molecule Inhibitors and Degraders for Brachyury and NEK1
No full textIn recent years, the discovery and characterization of various small-molecule binding proteins have shed valuable insights into the molecular mechanisms underlying biological processes and the development of new strategies for the treatment of diseases.1 However, significant portions of the human proteome remain understudied, such as proteins implicated in the development and progression of rare diseases. Herein, we describe our efforts to study two unrelated, biologically understudied protein targets in chemical biology research using small molecule inhibitors and degraders: brachyury and NEK1. With the initial hit molecules identified from small-molecule fragment screening using X-ray crystallography, our team synthesized analogs of scaffolds such as lactams, quinazolines, benzamides, and benzimidazoles to target various binding pockets of brachyury. Following the development of lead compounds from these scaffolds, small-molecule degraders were developed by chemically linking lead inhibitors with cereblon, an E3 ligase that ubiquitinates target proteins for degradation via the ubiquitin- proteasome system.2 While the biological assay for testing the degradation capacities of these degraders was being developed, we began a separate project to develop inhibitors for the understudied protein Nima-related kinase 1 (NEK1) in hopes of investigating its role in various biological processes such as cell cycle control, ciliopathies, and cancer.3Bachelor of Scienc
A study of the ability of two groups of freshmen students at Morehouse College to use the Trevor Arnett Library, 1953
No full text
Ice-Sheet flow in the Vicinity of Southern Victoria Land, Antarctica: Implications for Glacial Chronology
No full textAbstractSystematic radio echo-sounding during three seasons since 1971–72 has produced data on the configuration of the ice sheet in East Antarctica. In the sector extending inland from southern Victoria Land, the ice sheet exhibits a large ridge which drives ice towards David Glacier in the north and Mulock and Byrd Glaciers to the south. Within 100 km of the McMurdo dry-valley region soundings along ten sub-parallel lines (c. 10 km apart) provides detail on ice surface and flow patterns at the ridge tip. A small surface dome lies just inland of Taylor Glacier. The surface drops by 100 m or more before rising to join the major ridge in East Antarctica.</jats:p
Ice-Sheet flow in the Vicinity of Southern Victoria Land, Antarctica: Implications for Glacial Chronology
No full textAbstract
Systematic radio echo-sounding during three seasons since 1971–72 has produced data on the configuration of the ice sheet in East Antarctica. In the sector extending inland from southern Victoria Land, the ice sheet exhibits a large ridge which drives ice towards David Glacier in the north and Mulock and Byrd Glaciers to the south. Within 100 km of the McMurdo dry-valley region soundings along ten sub-parallel lines (c. 10 km apart) provides detail on ice surface and flow patterns at the ridge tip. A small surface dome lies just inland of Taylor Glacier. The surface drops by 100 m or more before rising to join the major ridge in East Antarctica.</jats:p
- …
