287 research outputs found
Hong Kong... la plus belle, la plus forte, la meilleure ? [Michael Enright, Edith Scott and David Dodwell, The Hong Kong Advantage]
No full textCini Francesca. Hong Kong... la plus belle, la plus forte, la meilleure ? [Michael Enright, Edith Scott and David Dodwell, The Hong Kong Advantage]. In: Perspectives chinoises, n°43, 1997. pp. 78-79
Hong Kong... la plus belle, la plus forte, la meilleure ? [Michael Enright, Edith Scott and David Dodwell, The Hong Kong Advantage]
No full textCini Francesca. Hong Kong... la plus belle, la plus forte, la meilleure ? [Michael Enright, Edith Scott and David Dodwell, The Hong Kong Advantage]. In: Perspectives chinoises, n°43, 1997. pp. 78-79
Residual disease after mastectomy
No full textCorrespondence:We read with interest the Comment by Orit Kaidar-Person and colleagues1 published in The Lancet Oncology
Multilevel Delayed Acceptance MCMC with Applications to Hydrogeological Inverse Problems
No full textQuantifying the uncertainty of model predictions is a critical task for engineering decision support systems. This is a particularly challenging effort in the context of statistical inverse problems, where the model parameters are unknown or poorly constrained, and where the data is often scarce. Many such problems emerge in the fields of hydrology and hydro--environmental engineering in general, and in hydrogeology in particular. While methods for rigorously quantifying the uncertainty of such problems exist, they are often prohibitively computationally expensive, particularly when the forward model is high--dimensional and expensive to evaluate. In this thesis, I present a Metropolis--Hastings algorithm, namely the Multilevel Delayed Acceptance (MLDA) algorithm, which exploits a hierarchy of forward models of increasing computational cost to significantly reduce the total cost of quantifying the uncertainty of high--dimensional, expensive forward models. The algorithm is shown to be in detailed balance with the posterior distribution of parameters, and the computational gains of the algorithm is demonstrated on multiple examples. Additionally, I present an approach for exploiting a deep neural network as an ultra--fast model approximation in an MLDA model hierarchy. This method is demonstrated in the context of both 2D and 3D groundwater flow modelling. Finally, I present a novel approach to adaptive optimal design of groundwater surveying, in which MLDA is employed to construct the posterior Monte Carlo estimates. This method utilises the posterior uncertainty of the primary problem in conjunction with the expected solution to an adjoint problem to sequentially determine the optimal location of the next datapoint.Engineering and Physical Sciences Research Council (EPSRC)Alan Turing InstituteEngineering and Physical Sciences Research Council (EPSRC
Age and sex can predict cancer risk in people referred with breast symptoms
No full textToral Gathani and colleagues argue that risk stratification by age and sex should be used to help manage demand on breast clinics efficiently to minimise delays in diagnosis</p
Sterile endophthalmitis rates and particle size analyses of different formulations of triamcinolone acetonide
No full textDavid G Dodwell,1 Darrel A Krimmel,1 Christopher M de Fiebre2 1Illinois Retina Center, Springfield, IL, USA; 2CMdeF Consulting, Upper Saint Clair, PA, USA Purpose: To evaluate the rate of sterile endophthalmitis (SE) following intravitreal injection of three different formulations of triamcinolone acetonide (TA) in a single physician practice and also to assess the mean diameter and concentration of particles of the two TA formulations currently available commercially in the USA. It was hypothesized that TA formulations with smaller particles and/or greater concentrations would have a higher incidence of SE.Methods: Single-site, interventional case series in which the medical records of 392 consecutive eyes receiving intravitreal TA as Triesence®, Kenalog®-40, or preservative-free TA between September 2008 and October 2013 were retrospectively reviewed for the incidence of SE. Particle sizing of TA formulations was conducted by an independent commercial laboratory.Results: Five cases of SE were identified. The four cases of SE following Triesence® (4.6%) represented a rate significantly higher than the one case of SE following preservative-free TA (0.6%; P=0.049) and the 0% incidence rate of SE following Kenalog®-40 (P=0.0210). Triesence® had significantly smaller particles than Kenalog®-40 (P<0.0001).Conclusion: The rate of SE was the highest with the formulation of TA that had the smallest particle size and highest particle load (number of particles injected). The lowest rate of SE was seen with Kenalog®-40, the only TA formulation that contained a benzyl alcohol preservative. The data do not support a principal causative role of benzyl alcohol in the development of TA-induced SE. Instead, the data support the particle theory of TA-induced SE; however, larger-scale, multicenter studies are needed to confirm and expand on these findings. Keywords: sterile endophthalmitis, benzyl alcohol, Triesence®, Kenalog®-40, preservative-free triamcinolone acetonide, particle size, frustrated phagocytosi
Oxford Polygons football team
No full textOxford Polygons football team formed in the late 80's to play an annual match against an SU team for the David Watson Trophy. This team features: Bob Pomfret, Media Workshop; Geoff Childs, Technology; Mark Dodwell, then Sports Director. Anyone care to name the others
Do surgical margins matter after mastectomy?: A systematic review
No full textBACKGROUND: No consensus exists regarding adequacy of margins after mastectomy. To determine if pathological margin proximity is associated with local (LR) or distant recurrence after mastectomy for early invasive breast cancer or ductal carcinoma in situ.METHODS: A systematic review of literature published from 1980 to 2019 and meta-analysis was conducted. Unpublished data were sought from authors (PROSPERO (CRD42019127541)). Thirty-four studies comprising 34,833 breast cancer patients were included in the quantitative synthesis. Eligible studies reported on patients undergoing curative mastectomy for cancer allowing estimation of outcomes in relation to margin status/width. The association between pathological margin status and local (LR) and distant recurrence was considered using random effects modelling. PRISMA guidelines were followed.RESULTS: Positive margins were associated with increased LR on multivariable analyses (HR, 2·64, (95%CI 2·01-3·46)) and LR was higher regardless of the distance of tumour from the margin defined as positive. After skin-sparing mastectomy, positive margins were associated with increased LR (HR 3·40, (95%CI 1·9-6·2)). In the 4 studies reporting distant recurrence, patients with involved margins had a higher risk (HR 1·53, (95%CI 1·03-2·25)).CONCLUSIONS: Failure to achieve clear margins after mastectomy may increase the risks of local and distant recurrence. Adequate margin clearance should be recommended to minimize recurrence after mastectomy in National and International Guidelines.</p
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