1,027 research outputs found
Efficacy of Anamorelin, a Novel Non-Peptide Ghrelin Analogue, in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) and Cachexia-Review and Expert Opinion
No full textCancer cachexia is a multilayered syndrome consisting of the interaction between tumor cells and the host, at times modulated by the pharmacologic treatments used for tumor control. Key cellular and soluble mediators, activated because of this interaction, induce metabolic and nutritional alterations. This results in mass and functional changes systemically, and can lead to increased morbidity and reduced length and quality of life. For most solid malignancies, a cure remains an unrealistic goal, and targeting the key mediators is ineffective because of their heterogeneity/redundancy. The most beneficial approach is to target underlying systemic mechanisms, an approach where the novel non-peptide ghrelin analogue anamorelin has the advantage of stimulating appetite and possibly food intake, as well as promoting anabolism and significant muscle mass gain. In the ROMANA studies, compared with placebo, anamorelin significantly increased lean body mass in non-small cell lung cancer (NSCLC) patients. Body composition analysis suggested that anamorelin is an active anabolic agent in patients with NSCLC, without the side effects of other anabolic drugs. Anamorelin also induced a significant and meaningful improvement of anorexia/cachexia symptoms. The ROMANA trials have provided unprecedented knowledge, highlighting the therapeutic effects of anamorelin as an initial, but significant, step toward directly managing cancer cachexia
Development of Indicators to Assess Quality of Care for Prostate Cancer
No full textAbstract not availableNupur Nag, Jeremy Millar, Ian D. Davis, Shaun Costello, James B. Duthie, Stephen Mark, Warick Delprado, David Smith, David Pryor, David Galvin, Frank Sullivan, Aine C. Murphy, David Roder, Hany Elsaleh, David Currow, Craig White, Marketa Skala, Kim L. Moretti, Tony Walker, Paolo De Ieso, Andrew Brooks, Peter Heathcote, Mark Frydenberg, Jeffery Thavaseelan, Sue M. Evan
sj-pdf-1-pmj-10.1177_02692163211040970 – Supplemental material for Performance status and trial site-level factors are associated with missing data in palliative care trials: An individual participant-level data analysis of 10 phase 3 trials
No full textSupplemental material, sj-pdf-1-pmj-10.1177_02692163211040970 for Performance status and trial site-level factors are associated with missing data in palliative care trials: An individual participant-level data analysis of 10 phase 3 trials by Jamilla A Hussain, Ian R White, Miriam J Johnson, Martin Bland and David C Currow in Palliative Medicine</p
sj-pdf-1-pmj-10.1177_02692163211045310 – Supplemental material for Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review
No full textSupplemental material, sj-pdf-1-pmj-10.1177_02692163211045310 for Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review by Belinda Butcher, Elizabeth Hutchings, Belinda Fazekas, Katherine Clark, Debra Rowett and David Currow in Palliative Medicine</p
sj-pdf-2-pmj-10.1177_02692163211045310 – Supplemental material for Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review
No full textSupplemental material, sj-pdf-2-pmj-10.1177_02692163211045310 for Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review by Belinda Butcher, Elizabeth Hutchings, Belinda Fazekas, Katherine Clark, Debra Rowett and David Currow in Palliative Medicine</p
Supplementary_Material_Interview_Schedule_-_Track_changes – Supplemental material for Nurses’ knowledge of law at the end of life and implications for practice: A qualitative study
No full textSupplemental material, Supplementary_Material_Interview_Schedule_-_Track_changes for Nurses’ knowledge of law at the end of life and implications for practice: A qualitative study by Lindy Willmott, Ben White, Patsy Yates, Geoffrey Mitchell, David C Currow, Katrin Gerber and Donella Piper in Palliative Medicine</p
sj-pdf-1-pmj-10.1177_02692163221122326 – Supplemental material for Paracentesis for cancer-related ascites in palliative care: An international, prospective cohort study
No full textSupplemental material, sj-pdf-1-pmj-10.1177_02692163221122326 for Paracentesis for cancer-related ascites in palliative care: An international, prospective cohort study by Davinia SE Seah, Andrew Wilcock, Sungwon Chang, Mariana S Sousa, Aynharan Sinnarajah, Cy Oun Teoh, Simon Allan, Richard Chye, Matthew Doogue, Jane Hunt, Meera Agar and David C Currow in Palliative Medicine</p
sj-pdf-2-pmj-10.1177_02692163221081331 – Supplemental material for Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review
No full textSupplemental material, sj-pdf-2-pmj-10.1177_02692163221081331 for Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review by Elin Baddeley, Mala Mann, Alison Bravington, Miriam J Johnson, David Currow, Fliss E M Murtagh, Elaine G Boland, George Obita, Alfred Oliver, Kathy Seddon, Annmarie Nelson, Jason W Boland and Simon I R Noble in Palliative Medicine</p
sj-pdf-3-pmj-10.1177_02692163221122352 – Supplemental material for The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review
No full textSupplemental material, sj-pdf-3-pmj-10.1177_02692163221122352 for The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review by Alison Bravington, George Obita, Elin Baddeley, Miriam J Johnson, Fliss EM Murtagh, David C Currow, Elaine G Boland, Annmarie Nelson, Kathy Seddon, Alfred Oliver, Simon IR Noble and Jason W Boland in Palliative Medicine</p
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