769 research outputs found
Wilmshurst in context
No full textDavid Colquhoun works on single ion channel function, both theory and experiment, and their relationship to synaptic function. He held the A.J. Clark chair of Pharmacology at UCL, and was previously honorary director of the Wellcome Laboratory for Molecular Pharmacology. He runs the Improbable Science blog.
[External Resource] A treatise on the police of the metropolis: containing a detail of the various crimes and misdemeanors by which public and private property and security are, at present, injured and endangered: and suggesting remedies for their preve
No full textThe author examined the rise of crime in eighteenth-century London, which he contended threatened to undermine the British empire. Therefore, Colquhoun offered a variety of methods to try to curb the spread of crime including relying on an improved police force
Non-covalent dimerisation of a bicyclic aromatic oligomer via loop–loop interlocking in the solid state
No full textA macrobicyclic ether-ketone oligomer containing twenty aromatic
rings has been isolated from the products of nucleophilic
condensation between 4,40-(9-fluorenylidene)diphenol and 1,3,5-
tris(40-fluorobenzoyl)benzene. Reduction of all six carbonyl
groups to methylene units yields a derivative which exhibits
non-covalent dimerisation in the crystalline state via shape-complementary
interlocking of fluorenylidene-containing ‘‘ loop ’’
regions
Gateway to Asia promoted by DARTI group. David Hancock
No full texttag=1 data=Gateway to Asia promoted by DARTI group. David Hancock
tag=2 data=Hancock, David
tag=3 data=Territory Business,
tag=6 data=First Quarter 1996
tag=7 data=20,21.
tag=8 data=TRADE%SOUTH-EAST ASIA
tag=9 data=ASEAN
tag=10 data=The NT's Department of Asian Relations, Trade and Industry leads Australia's push into the East ASEAN Growth Area. At the heart of this push is a group of people largely responsible for developing the NT's credibility in the region.
tag=13 data=IND
tag=32 data=MARWICK-SMITH, PATRICK%STONE, SHANE%MCCUE, JOHN%SAMMY, NATHAN%TREVENA, ROSS%LILLEY, DAVID%COLQUHOUN, JENNY%GALLAGHER, MIKEThe NT's Department of Asian Relations, Trade and Industry leads Australia's push into the East ASEAN Growth Area. At the heart of this push is a group of people largely responsible for developing the NT's credibility in the region
Patrick Colquhoun, the Scottish Enlightenment and Police Reform in Glasgow in the Late Eighteenth Century
No full textPatrick Colquhoun’s role in pioneering police reform in London has been widely documented. This paper seeks to examine from where his ideas and inspiration on law enforcement were derived. While it is recognised that Colquhoun drew and built upon the works of other police reformers and police models, it is argued that underlying many of his ideas were developments in policing which were taking place in his native Glasgow in the late eighteenth century – ideas, which in turn, were influenced by the intellectual and philosophical revolution known as the Scottish Enlightenment. In exploring this issue, the article will also examine the significant role played by the wider intellectual, commercial and political climate in shaping police reform in Scotland’s largest city.Le rôle pionnier de Patrick Colquhoun dans la réforme de la police londonienne a été largement démontré. Cet article vise à examiner l’origine de son inspiration et de ses idées sur la police. Il est admis que Colquhoun s’est appuyé sur le travail d’autres réformateurs de la police et sur d’autres modèles policiers, mais l’auteur argumente qu’une bonne partie de ses idées provenaient des innovations policières en cours à Glasgow, sa ville natale, à la fin du XVIIIe siècle. Ces innovations étaient elles-mêmes influencées par la révolution philosophique et intellectuelle des Lumières écossaises. Au passage, cet article retrace également le rôle significatif qu’a joué le climat intellectuel, commercial et politique dans la manière dont s’est effectuée la réforme policière dans la principale ville d’Écosse
Artistic biography as field theory: the case of Ithell Colquhoun - magician, surrealist, feminist
No full textRecent years have seen increased interest in the work of the British surrealist painter Ithell Colquhoun (1906–1988). This interest has been led by two constituencies: one feminist and the other esoteric. Both match dispositional characteristics of her work and address its significance within national and internal Surrealist movements. Rather than focus on feminist critiques or esoteric appraisals of Colquhoun, this article bases itself on the sociocultural aspects of her life and works. It builds on other studies from the author, which have employed the methodology developed by the French sociocultural theorist Pierre Bourdieu to the art “field.” Issues of research object construction are to the fore, together with analyses of the art and esoteric “fields” that involved Colquhoun. The article presents Colquhoun’s empirical biography (“habitus”), the networks she formed, and their relationship with the dominant “field” of cultural reproduction. Critical moments in her life trajectories are explored, detailing the breadth and focus of her influence with respect to the “Capitals”—“Social,” “Cultural,” and “Economic”—these levels of activities involved. Such analyses are set against exemplars from her painting as a way to compare the development of an esoteric aesthetic with her biographical experience. Issues of the artistic avant-gardes are also considered exemplified in her case. The article seeks to develop an understanding of the expressive impulse as it is manifested in transhistoric fields and the necessity of human creativity immanent within them
Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits
No full textThe subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization. Truncation of NMDA receptor subunits before the final TM showed that this TM and intracellular tail region are necessary to form functional channels. However, it is shown here that these truncated subunits may be partially rescued by coexpressing the final TM and tail as a separate protein. The whole-cell currents so produced are somewhat lower than with full-length subunits, and they do not show the sag characteristic of currents from channels containing NR1 and NR2A subunits in the continued presence of an agonist. In addition, these truncated subunits were joined to full-length subunits to generate tandems. The functional expression of these tandems confirmed the tetrameric structure of NMDA receptors and also suggested that the subunits making up NMDA receptors are arranged as a dimer of dimers in the receptors with a 1-1-2-2 orientation of the subunits in the channel, and not in an alternating pattern of subunits around the pore. These results may redirect future studies into the mechanism of binding and gating in these receptors toward schemes including dimers, and may also be relevant to studies of glutamate receptor ion channels in general
How to Impose Microscopic Reversibility in Complex Reaction Mechanisms
No full textMost, but not all, ion channels appear to obey the law of microscopic reversibility (or detailed balance). During the fitting of reaction mechanisms it is therefore often required that cycles in the mechanism should obey microscopic reversibility at all times. In complex reaction mechanisms, especially those that contain cubic arrangements of states, it may not be obvious how to achieve this. Three general methods for imposing microscopic reversibility are described. The first method works by setting the ‘obvious’ four-state cycles in the correct order. The second method, based on the idea of a spanning tree, works by finding independent cycles (which will often have more than four states) such that the order in which they are set does not matter. The third method uses linear algebra to solve for constrained rates
The structure and functions of the English magistrates' court : a study in historical sociology
No full textThis thesis starts with a critique of existing sociological
and criminological studies. The major argument here is that,
although interactionist studies are an improvement upon their
positivist counterparts, they suffer from the inherent weaknesses
contained in their astructural bias. Thus, although
observational studies have been able to describe the effects
of the process of interaction within the courtroom, they have
been unable to explain why magistrates' justice is characterised
by a relative lack of due process. In the main body of
the thesis, we offer a structural analysis of the functions of
magistrates' courts through an examination of the historical
development of the magistracy culminating in its transformation
in the middle of the nineteenth century. We show that
the magistracy was created in its modern form as a lower court
of summary justice specifically to act as an efficient method
of punishing petty offenders with a conscious disregard for
rights of due process. This did not simply reflect the
interests of the industrial bourgeoisie but rather it was a
product of the class struggle resulting from the particular
formation of British capitalism, in which the gentry retained
a powerful position. The central argument is that the
particular form of justice that is administered in the lower
courts of England and Wales reflects the compromise that was
reached between these two sections of the ruling class in the
period in which the modern magistracy was forged
Openings of the rat recombinant alpha1 homomeric glycine receptor as a function of the number of sgonist molecules bound
No full textThe functional properties of rat homomeric {alpha}1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat {alpha}1 subunit cDNA. Whole-cell dose-response curves gave EC50 estimates between 30 and 120 µM and a Hill slope of ~3.3. Single channel recordings were obtained by steady-state application of glycine (0.3, 1, or 10 µM) to outside-out patches. Single channel conductances were mostly 60–90 pS, but smaller conductances of ~40 pS were also seen (10% of the events) with a relative frequency that did not depend on agonist concentration. The time constants of the apparent open time distributions did not vary with agonist concentration, but short events were more frequent at low glycine concentrations. There was also evidence of a previously missed short-lived open state that was more common at lower glycine concentrations. The time constants for the different components of the burst length distributions were found to have similar values at different concentrations. Nevertheless, the mean burst length increased with increasing glycine. This was because the relative area of each burst-length component was concentration dependent and short bursts were favored at lower glycine concentrations. Durations of adjacent open and shut times were found to be strongly (negatively) correlated. Additionally, long bursts were made up of longer than average openings separated by short gaps, whereas short bursts usually consisted of single isolated short openings. The most plausible explanation for these findings is that long bursts are generated when a higher proportion of the five potential agonist binding sites on the receptor is occupied by glycine. On the basis of the concentration dependence and the intraburst structure we provide a preliminary kinetic scheme for the activation of the homomeric glycine receptor, in which any number of glycine molecules from one to five can open the channel, although not with equal efficiency
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