219 research outputs found
Influence of water on the electroanalytical behaviour of (K,Na)HSO4 eutectic melt. Characterization of Hg32+.
No full textErrata corrige, 69 (1979) Author Index, p. 3
Suicídio: Justificabilidade moral a partir do pensamento de David Hume
No full textO objetivo principal desta dissertação é refletir acerca da justificabilidade moral do suicídio a partir da teoria de David Hume. O suicídio representa um fenômeno perturbador encontra-se inserido no contexto histórico-filosófico e ressalta a importância das pesquisas, discussões e reflexões na sociedade contemporânea. A questão filosófica é: o suicídio é um ato moralmente justificável a partir do pensamento de David Hume? Para isso, pretende-se analisar a fundamentação teórica da moral e a possibilidade de expor o seu método empírico e a sua compreensão no contexto filosófico. Nesse sentido, a presente dissertação tem a pretensão de analisar um problema filosófico verdadeiramente sério: O suicídio e a justificabilidade moral. Para melhor compreender buscou-se apoio teórico na principal obra de Hume, O Tratado da natureza humana e Ensaios, Morais, Políticos e Literários. Como metodologia de pesquisa, utilizou-se um apoio teórico dos autores que dissertam sobre a problemática do suicídio como conduta humana. No primeiro momento, apresenta-se uma abordagem histórica-filosófica acerca do suicídio, sua incidência e considerações. Na sequência, consta uma contextualização sob a visão da área da saúde, da sociologia e da filosofia. No segundo momento, apresenta-se a filosofia Humeana e a construção da moralidade: o método empírico. No terceiro e último momento, destacam-se as ideias de David Hume aplicadas à justificabilidade moral do suicídio, bem como o uso da razão e a sensibilidade, para comprovar a sua verdade.In this thesis, the main objective is to reflect about the moral justificability of suicide starting from David Hume’s theory. Suicide represents a disturbing phenomenon that is inserted in the historical-philosophical context and emphasizes the importance of
research, discussions and reflections in contemporary society. The justification of this work is the need to conceive a causal relationship for suicide, that is, a prediction of cause and effect for the fact. With this, intervene in the breaking of taboos,
prevention and awareness of society on the subject. The philosophical question is whether suicide is a morally justifiable act from the thought of David Hume. For this, we intend to analyze the theoretical foundation of morality and the possibility of
exposing its empirical method and its understanding in the philosophical context. In this sense, the present dissertation intends to analyze a truly serious philosophical problem: Suicide and moral justification. In addition, specific objectives were defined to describe suicide from the perspectives of health, sociology, philosophy, and to understand David Hume's experimental method of reasoning for moral issues, analyzing empiricism, morality, causality, and unique experiences for social, political and personal criterion of suicide. To better understand, theoretical support was sought in the author's main work, The Treatise of Human Nature and Essays, Morals, Politicians and Literary where the related texts “Of Suicide” are found. As a research methodology, we used the theoretical support of the authors who talk about the problem of suicide as a human conduct. In the first moment, a historical-philosophical approach about suicide, its incidence and considerations is presented. Next, there is a contextualization from the viewpoint of health, sociology and philosophy. In the second moment, we present the Humean philosophy and the construction of morality: the empirical method. In the third and last moment, we highlight David Hume's ideas applied to the moral justification of suicide, as well as the use of reason and sensitivity to prove its truth
Soft panic
No full textCatalogue of an exhibition held at 200 Gertrude Street, Fitzroy, Victoria, 27 October - 18 November 2000Guest Curator: Mikala Dwyer
Artists: Carla Cescon, Tim Hilton, Michelle Seamons, David Jolly, Karen Kinder, Mary Teagu
District 8 baseball champions, 1971
No full textBack Row: Andy Bilesky, Steve Como, Gordon McLeod, Steve Unti, Bob Elliott, Mike Melatini, Rino Pozzobon, Ernie Secco. Front Row: Gordon Secco, Terry Hughes, Steve Zanier, Ron Bergen, Ricky Cescon, David Fletcher, Kenny Buna, Richard Mallinson
B.C. Little League champions, 1970
No full textBack Row: Ernie Secco, Rino Pozzobon, Bruce Ferguson, David Bay, Barry Zanier, Bob Elliott, Allan Pastro, Robert Volpatti, Andy Bilesky. Front Row: Ricky Cescon, Ron Bergen, Kelly Workman, John Mondin, Chris Vlanich, Steve Tambellini, Gordon McLeod
The use of the Hirsch index in benchmarking hepatic surgery research
No full textBACKGROUND: The Hirsch index (h-index) is recognized as an effective way to summarize an individual's scientific research output. However, a benchmark for evaluating surgeon scientists in the field of hepatic surgery is still not available.
METHODS: A total of 3,251 authors who published between 1949 and 2011 were identified using the Scopus identification number. The h-index, the total number of cited document, the total number of citations, and the scientific age were calculated for each author using both Scopus and Google Scholar.
RESULTS:The median h-index was 6 and the median scientific age, assessed with Google Scholar, was 19 years. The numbers of cited documents, numbers of citations, and h-indexes obtained from Scopus and Google Scholar showed good correlation with one another; however, the results from the 2 databases were modified in different ways by scientific age. By plotting scientific age against h-index percentiles an h-index growth chart for both Scopus database and Google Scholar was provided.
CONCLUSIONS: This analysis provides a first benchmark to assess surgeon scientists' productivity in the field of liver surgery
Team Strategy Optimization in Combined Resections for Synchronous Colorectal Liver Metastases. A Comparative Study with Bootstrapping Analysis
No full textBackground: The aim of the study was to evaluate perioperative outcomes and to evaluate factors influencing rative morbidity and adoption of minimally invasive technique in 1-team (1-T) versus two teams (2-T) management of synchronous colorectal liver metastases. Methods: Within four referral centers, a group of 234 patients treated in 1-T centers was identified and compared with a group of 253 patients treated in 2-T. A nonparametric bootstrap process was applied to the original cohorts of 1-T group and 2-T group as a resampling method to obtain bootstrapped cohorts (155 patients per group). Results: 33.5% of patients in 1-T boot group and 38.1% in the 2-T boot group were operated by laparoscopic approach. Multivariate analysis revealed that approach to primary tumor (laparoscopic or open) and intraoperative blood loss were independent prognostic factors for morbidity. Team approach did not show any significant correlation with incidence of postoperative complications nor with choice for laparoscopic approach. Conclusion: The optimization of team strategy for patients with SCRLM is not solely based on the adoption of a 1-T or 2-T approach, but should instead be based on the implementation of a standard protocol for management of these patients
Investigation of the Role of AID/APOBEC Cytidine Deaminases in Breast Cancer
No full textAbstract
The development of cancer from normal cells requires the acquisition of mutations in genomic DNA. Defects in DNA repair contribute to breast cancer predisposition and carcinogenesis in some individuals, including carriers of germline BRCA1 mutations. However, the additional factors responsible for mutagenesis in breast cancer have not been well defined. We hypothesized that AID/APOBEC cytidine deaminases â endogenous enzymes involved in innate and acquired immunity, which deaminate cytosine to uracil â could contribute to this process. Using genetically engineered mouse models, we showed that AID activity is present in mouse mammary epithelial cells and is modulated by hormonal factors, but that the absence of AID or APOBEC3 does not substantially limit the development nor affect the histology of spontaneous tumors in either a BRCA1-deficient or BRCA1-proficient context. In human cancer cell lines, functional genomic studies suggested that APOBEC3F, but not other APOBEC family members, was essential for proliferation and survival. APOBEC3F knockdown using siRNA and shRNA induced apoptosis and cell cycle arrest in a p21-dependent manner, but this was not an on-target effect. Bioinformatic analyses of large human cancer datasets revealed a strong association between APOBEC3B gene expression and proliferation in most solid tumor types. However, leveraging the existence of a germline APOBEC3B deletion polymorphism, we demonstrated that APOBEC3B does not cause this effect, and that its absence is not associated with clinical outcome or other standard clinicopathologic features in breast cancer. Instead, a pattern of immune activation was discovered in tumors arising in APOBEC3B deletion carriers, which may be relevant for the emerging field of cancer immunotherapy. In light of recent observations that a pattern of mutagenesis consistent with APOBEC activity is present in a wide range of cancers, the experimental results and tumour analyses reported here advance the understanding of the role of AID/APOBEC in breast and other cancers and will help to inform ongoing efforts to deduce the functional and therapeutic relevance of this phenomenon.Ph.D
Investigation of the Role of AID/APOBEC Cytidine Deaminases in Breast Cancer
No full textAbstract
The development of cancer from normal cells requires the acquisition of mutations in genomic DNA. Defects in DNA repair contribute to breast cancer predisposition and carcinogenesis in some individuals, including carriers of germline BRCA1 mutations. However, the additional factors responsible for mutagenesis in breast cancer have not been well defined. We hypothesized that AID/APOBEC cytidine deaminases â endogenous enzymes involved in innate and acquired immunity, which deaminate cytosine to uracil â could contribute to this process. Using genetically engineered mouse models, we showed that AID activity is present in mouse mammary epithelial cells and is modulated by hormonal factors, but that the absence of AID or APOBEC3 does not substantially limit the development nor affect the histology of spontaneous tumors in either a BRCA1-deficient or BRCA1-proficient context. In human cancer cell lines, functional genomic studies suggested that APOBEC3F, but not other APOBEC family members, was essential for proliferation and survival. APOBEC3F knockdown using siRNA and shRNA induced apoptosis and cell cycle arrest in a p21-dependent manner, but this was not an on-target effect. Bioinformatic analyses of large human cancer datasets revealed a strong association between APOBEC3B gene expression and proliferation in most solid tumor types. However, leveraging the existence of a germline APOBEC3B deletion polymorphism, we demonstrated that APOBEC3B does not cause this effect, and that its absence is not associated with clinical outcome or other standard clinicopathologic features in breast cancer. Instead, a pattern of immune activation was discovered in tumors arising in APOBEC3B deletion carriers, which may be relevant for the emerging field of cancer immunotherapy. In light of recent observations that a pattern of mutagenesis consistent with APOBEC activity is present in a wide range of cancers, the experimental results and tumour analyses reported here advance the understanding of the role of AID/APOBEC in breast and other cancers and will help to inform ongoing efforts to deduce the functional and therapeutic relevance of this phenomenon.Ph.D
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