24 research outputs found
Implementace jednoduchého operačního systému
No full textThis thesis focuses on the design and implementation of a simple operating system for the RISC-V architecture in C++. The system utilizes OpenSBI and U-Boot for bootstrapping and provides fundamental functionality, including memory management and protection, process scheduling, device drivers, and partial support for the FAT32 file system. The result of this work is a functional operating system kernel that enables multitasking and basic hardware interaction. The main contribution of the thesis is the creation of an open platform for RISC-V experimentation and low-level software development
The first copper (II) complex with 1,10-phenanthroline and Salubrinal with interesting biochemical properties
No full textThe novel copper complex [Cu(phen)2(salubrinal)](ClO4)2 (C0SAL) has been synthesised and characterised. Copper(II) is coordinated by salubrinal through the thionic group, as shown by the UV-Vis, IR, ESI-MS and tandem mass results, together with the theoretical calculations. The formed complex shown a DPPH radical scavenging ability higher than that of the salubrinal alone. Studies on the lipid oxidation inhibition, shown that the C0SAL concentration, required to inhibit the enzyme, was lower than that of salubrinal. The inhibition of the enzyme could take place via allosteric modulation, as suggested by docking calculations. C0SAL shown a good cytotoxic activity on A2780 cells, 82 fold higher than the precursor salubrinal and 1.4 fold higher than [Cu(phen)2(H2O)](ClO4)2. Treatment with C0SAL in SKOV3 ovarian cancer cells induced expression of GRP-78 and DDIT3 regulators of ER-stress response. The cytotoxic effect of C0SAL was reverted in the presence of TUDCA, suggesting that C0SAL induces the cell death by ER-stress. In A2780 cells treated with C0SAL γ-H2AX was accumulated, suggesting that also DNA was involved
The Problem of Silent Letters in English for Czech Native Speakers
No full textTato bakalářská práce se v teoretické části zabývá definicí němých písmen, vysvětlením důvodů jejich výskytu v Anglickém jazyce a také stručně nastiňuje jejich historický vývoj. V práci jsou dále představena jednotlivá němá písmena společně s pravidly a vzorci popisujícími jejich typický výskyt. Teoretická část také vysvětluje, proč by měla anglickým němým písmenům být v České republice věnována speciální pozornost.Praktická část je založena na lekci a sérii cvičení vytvořených s cílem prozkoumat a posléze rozšířit znalosti o němých písmenech u studentů. Cvičení byla vytvořena s ohledem na aktuálnost slov, která byla užita v příkladech. Jako rozhraní pro cvičení byl zvolen již zavedený univerzitní internetový kurz. Samotným cvičením předcházel diagnostický test, který zjišťoval úroveň znalostí studentů v oblasti němých písmen.In the theoretical part, the aim of the thesis is to define silent letters and explain the reasons for their appearance in the English language, as well as to briefly outline their historical development. Distinct silent letters are then introduced alongside with rules and patterns which describe their typical occurrence. The theoretical part also explains why there is a need for Czech learners of English to pay special attention to the problem of English silent letters. The practical part is based on an online lecture and series of exercises which I created with the aim of examining and subsequently helping students to improve their ' level of knowledge concerning silent letters. The exercises were created with regard to the currency of the words used as examples. For the examining and practising the interface of the university's already established e-learning course was chosen. The exercises were preceded by a diagnostic test, which was used to ascertain the students level of knowledge about silent letters
Additional file 2 of The functional evolution of termite gut microbiota
No full textAdditional file 2: Figure S1. Time-calibrated phylogenetic tree of termites inferred from mitochondrial genome sequences. Figure S2. Relative abundance of archaeal and bacterial phyla inferred from the termite gut metagenomes and the 16S rRNA amplicon data of 74 termite samples. Figure S3. Maximum likelihood phylogenetic tree inferred from 43 single-copy marker genes of 654 metagenome-assembled genomes (MAGs). The completeness and contamination of MAGs was inferred with CheckM [103]. Detailed information about each MAG is available in Table S9. Figure S4. Protein sequence alignment of predicted uricases from 53 termite transcriptomes previously published in Bucek et al. [27]
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Analysis of Emergency Medical Services in Austin, Texas Volume I: Results, PRP 41
No full textThis report, the first of two volumes, was produced by a policy research project in the academic year 1979-80. The study, funded by the City of Austin, the Texas Department of Human Resources, the Henry J . Kaiser Family Foundation, and the Lyndon Baines Johnson Foundation, developed a series of techniques to assist the City of Austin to deploy and manage emergency medical service vehicles. This volume provides statistical data about the Austin EMS system, including geographic and temporal distribution of historical EMS calls, geographic and ethnic distribution of the population, and performance of the current configuration of EMS vehicles. It then offers a vehicle deployment analysis which identifies alternative sites for basing service vehicles.Public Affair
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Analysis of Emergency Medical Services in Austin, Texas Volume II: Analytical Methods, PRP 41
No full textThis report was produced by a policy research project in the academic year 1979-80. The study, funded by the City of Austin, the Texas Department of Human Resources, the Henry J. Kaiser Family Foundation, and the Lyndon Baines Johnson Foundation, has developed a series of techniques to assist the City of Austin to deploy and manage emergency medical service vehicles. This volume presents user's manuals for four computer packages used by the EMS Policy Research Project in its analysis of emergency medical services in Austin.Public Affair
Gazeta Nowa (1990–1993): An abortive attempt to break the monopoly of the established party dailies
No full textPrezentowany artykuł jest prześledzeniem historii „Gazety Nowej”, jednego z pierwszych tytułów prasowych, w nowych po 1989 roku realiach społeczno-politycznych z perspektywy jej pomysłodawcy i realizatora — Andrzeja Bucka. Gazeta powstała w Zielonej Górze jako prywatny tygodnik, przekształcając się z czasem w gazetę codzienną, której mutacje ukazywały się w Głogowie, Gorzowie, Lubinie, a od 1992 r. także w Żarach. Autor przybliża okoliczności, w jakich powstawała gazeta, cele i zamierzenia, które przed sobą stawiała. Szczegółowo opisuje charakter i strukturę periodyku, imiennie przytaczając skład zespołu redakcyjnego. Z autopsji odtwarza fakty, które sprawiły, że „Gazeta Nowa” stała się przeciwwagą dla jedynego dotąd dziennika ukazującego się w regionie lubuskim — „Gazety Lubuskiej”. Szczegółowo analizuje przyczyny, z powodu których tytuł przestał się ostatecznie ukazywać w lipcu 1993 r.The article chronicles the history of Gazeta Nowa, one of the first new papers to be launched in Poland after the political breakthrough of 1989, from the perspective of its founder Andrzej Bucek. Started in Zielona Góra as a weekly, it soon transformed itself into a daily with local mutations in Głogów, Gorzów, Lubin, and after 1992 also in Żary. The article examines the circumstances of its launch and the expectations and aims of its founder, before focusing on the profile and structure of the paper (with a full list of its editorial staff). Drawing on his personal memories as well as generally known facts, the author analyzes first the rise of Gazeta Nowa to a position where it challenged the regional leader Gazeta Lubuska and then the problems which led to its demise in July 1993
Developmental changes induced by graded prenatal systemic hypoxic–ischemic insults in rats
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