43 research outputs found
Drs. David and Es Nash Awards Ceremony.
No full textVarious Jefferson learners who demonstrated innovation and dedication to improving the safety and quality of care were recognized with the Drs. David and Es Nash Safety and Quality awards. In addition, the very first Ira Brind Platinum Glove Award was also given to Jefferson Health employees who demonstrated their commitment to making our patient’s lives safer everyday through the OnPoint Great Catch Program
The Beautiful Things That Heaven Bears / Dinaw Mengestu
No full textFresh Reads was a reading program for incoming Freshmen. Christian Brothers University would collaborate with other Memphis libraries - Memphis Public Library in this year - to encourage group readings and to brind the author to town
A homecoming evening wtih Andrew Weil, MD
No full text\u22Health is a wholeness and balance, an inner resilience that allows you to meet the demands of living without being overwhelmed . . .\u22 -- Andrew Weil, MD
Andrew Weil, MD, delivered the inaugural lecture of the Brind Distinguished Lectureship in Integrative Medicine at Thomas Jefferson University Hospital on March 16, 2000.
A Philadelphia native and graduate of Harvard Medical School, Dr. Weil is a leader in the integration of Western medicine and alternative medicine. He is internationally recognized as a teacher, researcher and author.
He is the founder of the Program in Integrative Medicine at the University of Arizona Health Sciences Center, where he is training a new generation of physicians. An entertaining and informative speaker, Dr. Weil prescribes proven methods that will help you live healthier and assist your body in its efforts to heal naturally.
The one-hour lecture was originally recorded to videotape and later converted to QuickTime; quality is sometimes choppy
National Island Plan – Embedded Artist Commission: Exhibition – 'Angle of Vision'
No full textIn the summer of 2019, Irish artist Saoirse Higgins undertook a placement as Embedded Artist with Scottish Government, joining a consultation team that visited 40 of Scotland’s 93 inhabited islands - from the Shetland Islands to the Outer Hebrides, gathering the views of islanders in order to develop Scotland’s first National Islands Plan (NIP). This exhibition showcases newly commissioned work by Higgins resulting from this placement, being invited to respond to the consultation process from a different angle, connecting the voices and experiences of islanders and their sense of place in a different way.
Taking its title from a poem by Orcadian poet Robert Rendall (1898-1967), the exhibition focuses on the interactions between islanders and those arriving from the mainland by tracing the oscillating movement between two island viewpoints: one looking out from the island edge to sea – the islanders’ horizon; and the other looking in from the sea to the island – the ship’s eye view of the edge of the island, which islanders look out for on their journey home, or when taking themselves out to sea. In portraying this, Higgins draws from her conversations with islanders, geospatial data and 360-degree film footage, while using her own body as a cartographic tool – approaching, becoming entangled with, and connecting different island landscapes.
Higgins’ investigations of the sea to island viewpoint are influenced by a series of maps developed by 18th century hydrographer Murdoch Mackenzie (1712–1797), held in the collection of the Orkney Archive in Kirkwall and loaned to Pier Arts Centre specially for this exhibition. Mackenzie mapped Orkney, the Hebrides and Ireland, making the land the anchor point for the sea to make his maps. Mackenzie’s work made it safer for islanders to travel to and from islands and provides a good analogy with the Scottish Government’s National Island Plan as a tool aspiring to meaningfully improve the quality of life for island communities which simultaneously broadens connections and conversations with the mainland.
Higgins’ own mapping journey begins with 'Angle of Vision – Map of the Geographical Centre Point of 93 Inhabited Scottish Islands', developed in collaboration with cartographic design consultant Paul Naylor and technical consultant Chris Mee at Ordnance Survey. This map shows all inhabited Scottish islands with lines linking their individual calculated geographical centre points to their collective island nation centre. The mainland territories are absent in this map, emphasizing an island-centred viewpoint, which destabilizes dominant notions of centre and periphery. The map is displayed in the exhibition, as well as being available as a limited edition print, and is accompanied by is a specially designed Island Centre Marker Buoy with the mathematical formula that was used to calculate the island geographical centre points printed on its body.
The abstracted, geospatial information contained in the maps gives way to an embodied understanding of place in Higgins’ film 'Distant Views of the Land', adopting a land to sea view. The film was shot on the island of Papa Westray (also known as Papay) in Orkney, where she lives, on its most Northern point – called Fowl Flag. It shows a view out to sea from the land with Higgins standing right beside the viewer, who is invited to join in a moment of contemplation and survey the landscape together. While recalling imagery from art and literature in the Romanticism, including Caspar David Friedrich’s 1808 painting 'The Monk by the Sea', Higgins’ depiction of herself looking out to sea never stops being every-day, both in scale and sentiment, partaking in a sense of reverence for the landscape and collective guardianship over it that is integral to island life. Many islanders interviewed by the artist in Papay spoke to her of their close connection with the sea, and how the island’s boundedness by the ocean frames how they experience themselves in the landscape. The film’s audio track is of the sea around Papay, with 16-year old islander Jessie Dodman reading a text excerpt from Murdoch Mackenzie’s 1774 'Treatise on Maritime Surveying'. Our attention is drawn here to the younger generation, whose ideas and energy are core to the survival of islands, providing hope for the future.
Nestled between physical locatedness and an imagined elsewhere, Higgins’ works draw us into a lived, embodied experience of island life, imbued with geopolitical realities and a pressing sense of both urgency and optimism in looking to the future. Both close and distant, feet rooted to the ground as much as bird’s eye, these multi-faceted views of land and sea capture moments of alive, complex and caring occupancy of islands by different generations of islanders and visitors, underpinned by a shared awareness of the islands’ own vibrant presence and agency
The characterisation of Plc1 : a phospholipase C enzyme identified in the fission yeast Schizosaccharomyces pombe
No full textThe plc1 gene product (Plc1) of the fission yeast Schizosaccharomycespombe
(Sz. pombe) encodes a phosphoinositide-specific phospholipase C (PLC) and
most closely resembles the δ class of the PLC isozymes. PLC hydrolyses
phosphatidylinositol 4,5-bisphosphate (PIP2) producing two second messengers,
inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). The work in this
thesis is concerned with aspects of PLC signalling in Sz. pombe cells.
Sz. pombe cells lacking p1c1 (Δplc1) display a distinct phenotype. Δplc1 cells are
viable they grow slowly at 29'C (and below) on rich medium, but are unable to
grow under stressful conditions such as on minimal medium or at 37'C. Loss of
Plc1 function has been shown to cause missegregation of chromosomes and
enlarged cells with aberrant morphology (Fankhauser et al. 1995). Expression of
Plc1 in Δplc1 cells complemented for the loss of Plc1 and resulted in a wild-type
Sz. pombe phenotype.
Described in this thesis are the characterisation experiments carried out on Plc1.
Extracts prepared from wild-type Sz. pombe cells have undetectable Plc1 activity,
so an assay was designed, to measure Plc1 activity in vitro. The in vitro assay
and expression of Plc1 in Δplc1 cells formed the basis of a set of experiments
that helped identify a possible regulatory domain and roles for Plc1 in Sz. pombe
cells. Mutant forms of Plc1 were assayed in vitro to determine their level of
activity and were then expressed in Δplc1 cells to see if they were able to
complement for the loss of Plc1 activity.
Temperature sensitive mutants of Plc1 were constructed. This illustrated what
happened to a Sz. pombe cell with an active Plc1 at 23'C but when incubated at
37'C Plc1 activity is switched off. This demonstrated that cells lacking Plc1
activity could no longer divide and defects in cell wall structure began to appear.
Active site mutants of Plc1 were produced to identify whether InSP3 or DAG are
important second messengers in Sz. pombe cells. The Plc1 mutants were unable
to hydrolyse PIP2 but could hydrolyse phosphatidylinositol (PI). These mutants
hydrolyse PI producing DAG and InsP and were able to rescue the Δplc1
phenotype. This suggests that DAG production may play an important role in
regulating stress response pathways whereas InsP is recycled to produce
phosphatidylinositols.
Yeast PLCs have an extended N-terminal domain, which is not seen in any other
eukaryotic PLCs. To investigate the role of this N-terminal domain, mutants of
Plc1 and PLC-6 were constructed. They demonstrated that without the N-terminus
these mutants were active in vitro but were unable to complement for
the loss of Plc1 activity in Δplc1 cells. This indicates that the N-terminal domain
may play an important regulatory role
La recepción de Henri-René Lenormand en la España de principios de siglo XX
No full textEven if Lenormand’s works are barely read or played in actual days, he was one of the avant-garde authors that generated more attention in the early twentieth century. The French author was enthusiastically welcomed by Spanish public. His works were frequently translated and played in Spanish theaters and intense debates were hold in literary reviews about how to interpret his characters. However, Lenormand’s psychological conception of human being divided Spanish criticism in two groups: those who were in favour of his freudian proposals and those conservative critics who rejected Lenormand’s novelties because they did not fit in the theatrical trends prevailing in early twentieth century Spain. Another controversial aspect in the Spanish reception of Lenormand’s works was the alleged innovative nature of his theater: was he really an avant-garde author or did he merely relocate the great dramas of classical theater into the twentieth century? The aim of this paper is to study the diverse reactions stimulated by Lenormand’s works among Spanish criticism.Pese a que actualmente apenas es leído o representado en los teatros, Lenormand fue uno de los autores vanguardistas que más interés generó a principios de siglo XX. La acogida que el público español brindó al autor francés fue especialmente calurosa. Sus obras se traducían y representaban con frecuencia, y suscitaban intensos debates en las revistas literarias. Sin embargo, la concepción psicológica del ser humano que Lenormand ofrecía en sus dramas dividió en dos a la crítica española: aquellos que defendían sus propuestas freudianas y aquellos otros sectores más conservadores que rechazaron las novedades lenormandianas por no encajar en las tendencias teatrales que imperaban en la España de principios de siglo XX. Otro de los aspectos controvertidos en la recepción española de Lenormand fue el supuesto carácter innovador de su teatro: ¿era realmente un autor vanguardista o se limitaba a trasladar al siglo XX los grandes dramas del teatro clásico? En este trabajo estudiaremos las diversas reacciones que la obra de Lenormand suscitó entre los críticos españoles de principios de siglo XX
Application of KRR, K-NN and GPR Algorithms for Predicting the Soaked CBR of Fine-Grained Plastic Soils
No full textCalifornia bearing ratio (CBR) test is one of the comprehensive tests used for the last few decades to design the pavement thickness of roadways, railways and airport runways. Laboratory-performed CBR test is considerably rigorous and time-taking. In a quest for an alternative solution, this study utilizes novel computational approaches, including the kernel ridges regression, K-nearest neighbor and Gaussian process regression (GPR), to predict the soaked CBR value of soils. A vast quantity of 1011 in situ soil samples were collected from an ongoing highway project work site. Two data divisional approaches, i.e., K-Fold and fuzzy c-means (FCM) clustering, were used to separate the dataset into training and testing subsets. Apart from the numerous statistical performance measurement indices, ranking and overfitting analysis were used to identify the best-fitted CBR prediction model. Additionally, the literature models were also tried to validate through present study datasets. From the results of Pearson’s correlation analysis, Sand, Fine Content, Plastic Limit, Plasticity Index, Maximum Dry Density and Optimum Moisture Content were found to be most influencing input parameters in developing the soaked CBR of fine-grained plastic soils. Experimental results also establish the proficiency of the GPR model developed through FCM and K-Fold data division approaches. The K-Fold data division approach was found to be helpful in removing the overfitting of the models. Furthermore, the predictive ability of any model is considerably influenced by the geological location of the soils/materials used for the model development. © 2023, The Author(s)
Anglo-Australian Naval Relations and Co-operation, 1945-1975
No full textThis thesis explores the relationship between the Royal Australian Navy (RAN) and the Royal Navy (RN) between 1945-75. My original contribution to knowledge is assessment of a historical topic that is greatly under-researched. In addition this research has revealed instances where naval policy in both the United Kingdom and Australia was in direct contrast to national policy, a topic that has not been previously addressed in an Anglo-Australian context.
The aim of this study is to analyse the changing relationship between the Royal Navy and the RAN in the post-Second World War period, specifically 1945-75. Particular areas of interest include the alterations in inter-service cultural ties, operational co-operation, collaboration in matters of personnel, and equipment procurement and design. As national policy and strategic concerns have an impact on lower-level military affairs, assessment is also made of the altering national and strategic relations between Australia and Great Britain in the same period. This includes consideration of the diminution of British military influence in the Asia-Pacific region, as well as the strategic shift of Australia towards the United States in the post-war period.
The methodology of the study is based on analysis of primary sources such as governmental archives, oral recordings and unpublished memoirs from United Kingdom and Australian archives. Consideration has been made of secondary sources concerning both the RAN and the Royal Navy to provide historiographical context to the research topic. Statistical assessment of the RAN Navy List’s from 1945-75 has also been made to chart the movement of officers between the Royal Navy and the RAN.
This thesis concludes that the relationship between the Royal Navy and the RAN between 1945-75 underwent a great level of change. This modification in some ways mirrored the gradual disassociation between Great Britain and Australia in the same period but the shift in naval relations did not take place at the same time, nor did the alteration in naval relations occur for the same reasons
