404 research outputs found
David Botstein Part 1: Fruits of the Genome Sequences
No full textThis lecture from the iBioSeminars project is presented by David Botstein from Princeton University. It presents an overview of the benefits for science and society derived from sequencing the genomes of multiple organisms, including humans. The sequences show that many genes have been conserved during evolution; a finding that allows scientists to study simple organisms such as yeast and relate their findings to mammalian biology. In addition, mining genome sequences has identified numerous genes involved in human disease, in some cases resulting in improved screening and treatment. This video is the first of two, running 52:11 minutes and can be downloaded in QuickTime, MP4, M4V, or PDF formats. It can also be streamed on iTunes or YouTube
David Botstein Part 1: Fruits of the Genome Sequences
No full textThis lecture from the iBioSeminars project is presented by David Botstein from Princeton University. It presents an overview of the benefits for science and society derived from sequencing the genomes of multiple organisms, including humans. The sequences show that many genes have been conserved during evolution; a finding that allows scientists to study simple organisms such as yeast and relate their findings to mammalian biology. In addition, mining genome sequences has identified numerous genes involved in human disease, in some cases resulting in improved screening and treatment. This video is the first of two, running 52:11 minutes and can be downloaded in QuickTime, MP4, M4V, or PDF formats. It can also be streamed on iTunes or YouTube
Connecting Growth Control and Stress Response
No full textThis lecture from the iBioSeminars project is presented by David Botstein from Princeton University. It presents experiments done in Botstein's lab studying, in yeast, the coordination of growth rate, stress response, metabolism and cell division. Using innovative methods to color code and cluster numerical data from DNA hybridization experiments allows the identification of genes involved in regulating how fast cells grow under different conditions. This video is the second of two, running 46:00 minutes and can be downloaded in QuickTime, MP4, M4V, or PDF formats. It can also be streamed on iTunes or YouTube
Mapping the Human Genome with D A Polymorphisms
No full text(This information was taken from the Distinguished Scientist Lecture Series Program 1983-1984).
Dr. Botstein is Professor of Biology at Massachusetts Institute of Technology. Born in Zurich, he received the Ph.D. degree in human genetics with a subspecialty in microbial genetics from the University of Michigan. He has been the recipient of a Woodrow Wilson National Fellowship, an IH Career Development Award, and the Eli Lily & Company Award in Microbiology and Immunology. He was elected to the National Academy of Sciences in 1981. Dr. Botstein serves on the editorial boards of journal of Virology, and Genetics, and the advisory committee of the ACS Study Section on Virology and Cell Biology. He has also been a member of the advisory committee of the National Science Foundation Study Section on Genetics and Biology. The author of Advanced Bacterial Genetics:.A Manual for Genetic Engineering (1980), Dr. Botstein has contributed to many professional journals, including the Proceedings of the National Academy of Science, U S.A, Cell, and Gene.
His Work:Dr. Botstein\u27s research has concerned itself with the molecular biology of the life cycle of the temperate Salmonella phage P22, and with several aspects of the molecular genetics of yeast.
His Lecture: May 5, 1984: Mapping the Human Genome D A Polymorphismshttps://digitalcommons.bard.edu/dsls_1983_1984/1001/thumbnail.jp
Brave new worlds: experimentalism between the wars
No full textIntroduction: trajectories of twentieth-century music Nicholas Cook with Anthony Pople; 1. Peripheries and interfaces: Western music and its others Jonathan Stock; 2. Music of a century: museum culture and the politics of subsidy Leon Botstein; 3. Innovation and the avant-garde, 1900 1920 Christopher Butler; 4. Music, text and stage: the tradition of bourgeois tonality, 1900 1930 Stephen Banfield; 5. Classic jazz to 1945 James Collier; 6. Flirting with the vernacular: America in Europe, 1900 1945 Susan Cook; 7. Between the wars: traditions, modernisms and the ‘‘little people’ from the suburbs’ Peter Franklin; 8. Brave new worlds: experimentalism between the wars David Nicholls; 9. Proclaiming a mainstream: Schoenberg, Berg, and Webern Joseph Auner; 10. Rewriting the past: classicisms of the interwar period Hermann Danuser; 11. Music of seriousness and commitment: the 1930s and beyond Michael Walter; 12. Other mainstreams: light music and easy listening, 1920 70 Derek Scott; 13. New beginnings: the international avant-garde, 1945 62 David Osmond-Smith; 14. Moderate modernisms: individualism and accessibility, 1945 75 Arnold Whittall; 15. After swing: modern jazz and its impact Mervyn Cooke; 16. Music of the youth revolution: rock through the 1960s Robynn Stilwell; 17. Expanding horizons: the international avant-garde, 1962 75 Richard Toop; 18. To the millennium: music as commodity Andrew Blake; 19. Ageing of the new: the museum of musical modernism Alastair Williams; 20. (Post)-minimalisms, 1975 2000: the search for a new mainstream Robert Fink; 21. History and class consciousness: pop music towards 2000 Dai Griffiths; 22. ‘Art’ music in a cross-cultural context: Africa towards 2000 Martin Scherzinger; Appendices: 1. Personalia Peter Elsdon with Björn Heile; 2. Chronology Peter Elsdon and Peter Jones
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Cinderella; or Music and the Human Sciences. Unfootnoted Musings from the Margins
No full textIt has become fashionable among scholars to wax autobiographical with the reader, presumably to shed any remnant of the illusion (suggested implicitly by the conventional apparatus of a scholarly text and footnotes) that one might be speaking with an objective voice, or with an argument
whose merits can be considered and even accepted without reference to personal and therefore circumstantial prejudice. Today's penchant for presumed full disclosure of one's subjective standpoint, however, is more likely either a species of authorial vanity masquerading as methodological scrupulousness or evidence of a greater interest in oneself than the subject
one is writing about. In this case, the reader who wishes to distill the prejudices of the author and speculate on their origins must begin with the author's notion that one can talk effectively about the character and value of arguments by using procedures of reading and research that hold
up under scrutiny and require no subjective apologetics. Botstein concludes that the definition of future methods of analysis, including the setting of the research agenda, cannot be undertaken from within the current traditions of music history or musicology
The Future of Early College: An Interview with Dr. Leon Botstein
No full textThe first public, tuition-free Bard High School Early College (BHSEC) opened in Brooklyn in 2001. Today, an entire network of Bard Early Colleges operates in partnership with public school systems to offer students affordable access to higher education in a cohesive, engaging environment. Simultaneously, alternative takes on early college (Early College High Schools, dual enrollment, early entrance) have proliferated across the United States, providing even more opportunities for younger students to earn college credit.
In December 2022, the author, Dean of Bard Early College, sat down with Bard College President Leon Botstein to examine how the pandemic made new demands of educators everywhere. Together, they looked ahead to the next two decades of public early college, taking a closer look at some limiting and unexamined assumptions about adolescent education, equity, and inclusion, and predicted the ways Bard Early College can meet the academic, social, and developmental needs of current and future students
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins
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