29 research outputs found
sj-pdf-1-jso-10.1177_23971983221138712 – Supplemental material for Development and validation of Hebrew version of the UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0
No full textSupplemental material, sj-pdf-1-jso-10.1177_23971983221138712 for Development and validation of Hebrew version of the UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0 by David Ozeri, Shani Peretz, Amit Oppenheim, Abdallah Watad, Merav Lidar and Yolanda Braun-Moscovici in Journal of Scleroderma and Related Disorders</p
The role of inhibitory deep dorsal horn parvalbumin interneurons in multimodal sensorimotor integration for locomotion
No full textTo achieve smooth motor performance in a rich and changing sensory environment, motor outputs must be constantly updated in response to sensory feedback. Although proprioception and cutaneous information are known to modulate motor output, it is unclear how they work together in the spinal cord to shape rhythmic motor actions, such as locomotion. Here we identify the medial deep dorsal horn (mDDH) as the epicenter for convergent proprioceptive and cutaneous information, recruited during walking. Within this zone of convergence we find that inhibitory neurons are particularly recruited, likely due to increased excitability and sensitivity to sensory input. To study inhibitory neurons in this region, we target a large group of glycinergic mDDH interneurons identified by their expression of parvalbumin (dPVs). dPV electrophysiological and morphological properties demonstrate recruitment during locomotion, role in sensorimotor processing, and high-gain, faithful encoding of sensory input. In support of a role in sensorimotor processing, we identify dPVs as a node for multimodal convergence (proprioceptive, cutaneous and cortical input) and output divergence, inhibiting diverse motor and premotor neurons. We demonstrate that the temporal dynamics of dPV activity is shaped by activation of sensory inputs; reducing spike timing variability and promoting oscillatory- like activity. We therefore propose that sensory-evoked activity in dPVs set the timing of output targets. To test this hypothesis, we devise a genetic strategy for specific ablation of dPVs. Electromyogram muscle recordings reveal that dPV ablation results in faster sensory- evoked muscle response, due to loss of dPV inhibition. dPV ablation does not change mice corrective reflexes. However, we observe phase- and speed-dependent changes to stride duration, frequency, interlimb coordination, gait transitions, and joint angles during treadmill walk. Together, our data suggest that convergent sensory inputs work in concert to coordinate the activity of dPVs, and in-turn regulate motor output in a contextually relevant manner.Ph.D.Includes bibliographical reference
Repeat Biopsy of IgG4-Related Ophthalmic Disease Identifies Superimposed Herpes Simplex Virus Infection: A Case Report
No full textUnprovoked Pulmonary Embolism Identified on Initial Presentation of Adult-Onset Still Disease in an Elderly Patient With No Malignancy
No full textDermatological Comorbidities in Patients with Familiar Mediterranean Fever
No full textAbstract is missing (Short communication
Volvulus and Under Appreciated Complication of Mixed Connective Tissue Disease: A Case Report
No full textRetropharyngeal tendinitis: Hydroxyapatite deposition driven headache and nuchal rigidity resolves with prednisone
No full textWe present a case of a 42-year-old woman who presented with sudden onset severe headache, neck pain, and nuchal rigidity associated with dysphagia. The initial differential in this patient included meningitis or retropharyngeal abscess, and an extracranial neck CT showed an ill-defined hypo-attenuated lesion within the retropharyngeal space. However, the neck pain and dysphagia were unresponsive to empirical antibiotic treatment and pain management. Further CT with contrast identified acute calcific tendonitis of the longus colli tendon, also known as retropharyngeal tendonitis (RCT). Although RCT is already known as a rare, self-limiting inflammatory condition, we present a new case of RCT, with the uncommon features of headache and nuchal rigidity in an aseptic patient, while providing a diagnostic flow chart to guide the clinical work-up of similar presentations to also include RCT.</jats:p
