1,721,696 research outputs found
Uno sguardo sui borghi antichi e le città artistiche del Sud
No full textL’Associazione Culturale “Il Sileno” ha organizzato nei giorni 3, 4 e 5 maggio 2017, presso la Sala Mostre dell’Aula Magna “B. Andreatta” dell’Università della Calabria, la mostra fotografica “Uno sguardo sui borghi antichi e le città artistiche del Sud”, curata dai dottori di ricerca Valeria Dattilo e Francesco De Pascale.
La manifestazione, sostenuta dall’Università della Calabria, è stata anche patrocinata dal Dipartimento di Storia, Società e Studi sull’Uomo dell’Università del Salento, dalla Società Geografica Italiana, dalla Società di Studi Geografici, dall’Associazione Italiana Insegnanti di Geografia, sezione Calabria, dal Comune di Lago, dalla Consulta delle Associazioni di Tropea e del Territorio, dalla Pro loco di Parghelia e dall’associazione di promozione sociale “Cosi Mali” di Zambrone.
Il principale obiettivo della mostra è stato quello di accentrare l’attenzione di tutti (governi, amministrazioni, cittadini, studenti) sulle notevoli ricchezze culturali e artistiche presenti nel Sud Italia, che rischiano di cadere nell’oblio. Tra l’altro, il Sud Italia è l’area a più alto rischio sismico d’Italia e i governi locali, le Amministrazioni Comunali del Sud Italia dovrebbero prendere consapevolezza della rilevanza dello straordinario patrimonio artistico-monumentale di cui dispongono: centri storici di incredibile bellezza, un immenso patrimonio culturale da salvaguardare. Infatti, i centri storici devono essere restaurati ed abbelliti, recuperando, così, un giacimento inesauribile di bellezza e di attrattività.
È, allora, necessario che il patrimonio culturale, espressione più alta delle capacità creative di un popolo, sia tutelato e valorizzato dalle istituzioni, dalle università e con la partecipazione attiva dei cittadini, contribuendo a rafforzare la coesione sociale delle comunità e a creare le migliori condizioni per lo sviluppo socio-economico dei territori.
L’inaugurazione della mostra si è svolta mercoledì 3 maggio 2017 alle 15. La mostra è proseguita il 4 maggio dalle 9 alle 17 e il 5 dalle 9 alle 14
Long term noise measurements and MTF test for the characterization of Electromigration in metal lines
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The VIRGO suspensions: Design and recent performance measurements
No full textThe success of the VIRGO interferometer to detect gravitational waves, starting from a few Hz, depends on the ability of its suspension systems to isolate the test masses from seismic noise and to maintain them actively at a working position with relative displacement of ∼ 10-12 m rms on a time scale of several hours. For this purpose, considerable development effort has been dedicated to realize a multi-stage vibration isolator to suspend the test masses: the SuperAttenuator (SA). It has been designed to provide an attenuation of more than 10 orders of magnitude starting from about 4 Hz. Hierarchical control forces, exerted via coil-magnet actuators placed at three different stages of the SA, damp the fundamental mechanical modes of the system (all below 2 Hz) and maintain the relative orientation and position of the test mass for interferometer alignment and locking. In this Letter a description of the SA is given and recent experimental results are presented. © 2003 Elsevier B.V. All rights reserved
The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms
No full textMajor depressive disorder (MDD) is a heterogeneous psychiatric disease characterized by persistent low mood, diminished interests, and impaired cognitive and social functions. The multifactorial etiology of MDD is still largely unknown because of the complex genetic and environmental interactions involved. Therefore, no established mechanism can explain all the aspects of the disease. In this light, an extensive research about the pathophysiology of MDD has been carried out. Several pathogenic hypotheses, such as monoamines deficiency and neurobiological alterations in the stress-responsive system, including the hypothalamic–pituitary–adrenal (HPA) axis and the immune system, have been proposed for MDD. Over time, remarkable studies, mainly on preclinical rodent models, linked the serum- and glucocorticoid-regulated kinase 1 (SGK1) to the main features of MDD. SGK1 is a serine/threonine kinase belonging to the AGK Kinase family. SGK1 is ubiquitously expressed, which plays a pivotal role in the hormonal regulation of several ion channels, carriers, pumps, and transcription factors or regulators. SGK1 expression is modulated by cell stress and hormones, including gluco- and mineralocorticoids. Compelling evidence suggests that increased SGK1 expression or function is related to the pathogenic stress hypothesis of major depression. Therefore, the first part of the present review highlights the putative role of SGK1 as a critical mediator in the dysregulation of the HPA axis, observed under chronic stress conditions, and its controversial role in the neuroinflammation as well. The second part depicts the negative regulation exerted by SGK1 in the expression of both the brain-derived neurotrophic factor (BDNF) and the vascular endothelial growth factor (VEGF), resulting in an anti-neurogenic activity. Finally, the review focuses on the antidepressant-like effects of anti-oxidative nutraceuticals in several preclinical model of depression, resulting from the restoration of the physiological expression and/or activity of SGK1, which leads to an increase in neurogenesis. In summary, the purpose of this review is a systematic analysis of literature depicting SGK1 as molecular junction of the complex mechanisms underlying the MDD in an effort to suggest the kinase as a potential biomarker and strategic target in modern molecular antidepressant therapy
The antiseismic suspension for the VIRGO project
No full textGravitational waves propagating from rapidly accelerating star masses can be detected by means of interferometric techniques. Several interferometric antennas are presently under construction around the world with the aim of gravitational waves detection in the frequency range starting from a few tens of Hz to a few kHz. In the low frequency region (below a few tens of Hz) their detection is limited by seismic noise which can mask the weak signal induced by a gravitational wave impinging on a suspended mirror. In order to overcome this limitation, the VIRGO collaboration has developed and built a sophisticated suspension system to isolate the optical components from the seismic noise. This mechanical system, called SuperAttenuator, is able to inhibit the transmission of any mechanical disturbances starting from about 4 Hz thus extending the detection band in the low frequency region
Low frequency noise evolution during lifetime tests of lines and vias subjected to electromigration
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