122,502 research outputs found
Trabajo de las glándulas digestivas y mecanismo defensivo del aparato gastro-intestinal contra las toxinas : Tesis presentada para optar al grado de doctor en medicina
No full textFil: Dasso, Bernardino F. Universidad de Buenos Aires. Facultad de Medicina. Buenos Aires, Argentina.A la cabeza de portada: Universidad Nacional de Buenos Aires. Facultad de Ciencias Médicas. - Incluye nómina de Catedráticos y Asignaturas. Tesis con dedicatoria
Boson Transition Densities Within the Interacting-boson-model Picture - Rotational Limit
No full text
Marie-Josée Cesarini-Dasso : L'Univers criminel féminin en Corse à la fin du 18e siècle, (Coll. «Histoire et société ».) 1996
No full textMilleliri Paulette. Marie-Josée Cesarini-Dasso : L'Univers criminel féminin en Corse à la fin du 18e siècle, (Coll. «Histoire et société ».) 1996. In: Dix-huitième Siècle, n°29, 1997. Le vin, sous la direction de Jean Bart et Élisabeth Wahl. p. 623
Targeting both the hydrophobic pocket and N-terminus of HIV-1 nucleocapsid protein 7: synthesis and optimization of new antiretroviral compounds.
No full textDuring the past 25 years, the arsenal of drugs to combat HIV-1 infection has increased continuously, even though most anti-HIV-1 drugs experienced clinical failure due to antiretroviral drug resistance resulting from mutations in HIV-1 protein targets. Therefore, a medical need in this field is still felt, and additional conserved drug targets need to be explored to achieve virus suppression in drug-experienced patients or patients infected with drug-resistant viruses. In this context, the Nucleocapsid protein 7 (NCp7) is considered a strongly profitable drug target as it is a highly conserved protein in several HIV-1 subtypes that plays a central role in virus replication, and whose inhibition could interfere with multiple steps in the HIV-1 life, a unique property not shown by any of the other antiretroviral classes.
This PhD thesis has been devoted to the discovery and synthesis of NCp7 inhibitors characterized by a bifunctionalized structure with the aim to block two binding sites within NCp7.
The first synthetic efforts were addressed to the development of an easy and reproducible synthetic pathway for obtaining desired products which could then be applied for the synthesis of derivatives. All compounds were tested for their antiviral activity as well as for NCp7 inhibition. Results showed that this class of compounds displays a very interesting profile. The second part of the work focused on the preparation and characterization of a liposomal formulation of a selected compound as drug delivery system with the aim to improve its pharmacokinetic profile
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A qualitative descriptive inquiry of the influences on nurses’ missed care decision-making processes in acute hospital paediatric care
No full textAim: To explore influences on nurses’ missed care decision-making processes in acute hospital paediatric care. Background: Many contemporary studies describe the phenomenon of missed care. It is clear that environment and organizational culture influence the nursing activities; however, what influences their decision-making processes has not been investigated. Method: A descriptive qualitative inquiry was performed using semi-structured interviews with paediatric nurses (n = 20) from one Italian paediatric hospital. Findings: Thematic analysis revealed four themes: nurses’ value system; hospital logistics, structures and resources; prioritization processes; and the informal caregiver's role. Conclusion: This paper offers insights into the various factors involved in nurses’ decision-making process when contemplating missed care that will be of use to managers when planning care or addressing missed care in the paediatric clinical setting. Implications for Nursing Management: Knowledge and awareness of missed care in children's nursing needs greater exploration, especially in relation to what influences nurses’ decision-making choices around missed care. Overall, a greater understanding of this will help managers to manage situations effectively and ethically so that missed care does not impact on outcomes for children in health care
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
Relación entre el contenido de la lonchera y la experiencia de caries dental en niños de educación pre escolar de 3 a 5 años de la I. E. David Dasso Nº 1686 del distrito de Nuevo Chimbote - Santa (costa) y la I. E. Enrico Capelletti N° 185, del distrito de Tauca – Pallasca (sierra). Áncash – 2018
No full textLa presente investigación tuvo como objetivo conocer la “relación entre el contenido de la lonchera y la experiencia de caries dental en niños de educación pre escolar de 3 a 5 años de la I.E. David Dasso Nº 1686 del Distrito de Nuevo Chimbote-Santa (Costa) y la I.E. Enrico Capelletti N° 185, del distrito de Tauca–Pallasca (Sierra). Ancash – 2018”, cuya metodología fue de diseño no experimental, transversal, prospectivo y relacional, con una muestra de 126 alumnos de 3 a 5 años entre ambas Instituciones Educativas; donde los resultados mostraron que no existe relación entre el contenido de la lonchera y experiencia de caries en la I.E. David Dasso Nº 1686 (p= 0.452) ni en la I.E. Enrico Capelletti N° 185 (p= 0.181), pero se mostró que los niños con ceo-d severo presentaron una mayor concentración en el grupo expuesto a loncheras cariogénicas, con un 78,8% en la costa, así como en la sierra con un 75,5%. Asimismo, no hubo relación entre la experiencia de caries y las variables nivel de ingresos económicos, edad del niño, edad de la madre o apoderado, nivel educativo de la madre o apoderado y número de hermanos de ambas Instituciones Educativas, menos con el sexo de los niños de la I.E. Enrico Capelletti N° 185; pero si hubo relación con el sexo de los niños de la I.E. David Dasso Nº 1686 (p=0.033), por lo que se concluye que no existe relación entre las variables estudiadas de lonchera escolar y experiencia de caries.Tesi
- …
