85 research outputs found
Sparse multiway canonical correlation analysis for multimodal stroke recovery data
No full textConventional canonical correlation analysis (CCA) measures the association between two datasets and identifies relevant contributors. However, it encounters issues with execution and interpretation when the sample size is smaller than the number of variables or there are more than two datasets. Our motivating example is a stroke-related clinical study on pigs. The data are multimodal and consist of measurements taken at multiple time points and have many more variables than observations. This study aims to uncover important biomarkers and stroke recovery patterns based on physiological changes. To address the issues in the data, we develop two sparse CCA methods for multiple datasets. Various simulated examples are used to illustrate and contrast the performance of the proposed methods with that of the existing methods. In analyzing the pig stroke data, we apply the proposed sparse CCA methods along with dimension reduction techniques, interpret the recovery patterns, and identify influential variables in recovery.
???? The Twin Ropes of Time and Life
No full textThis paper presents the Twin Ropes Theory, a comprehensive metaphysical framework that revolutionizes our understanding of temporal existence through the lens of parallel dimensional constructs. The theory conceptualizes Time and Life as two infinite ropes stretching through the fabric of existence, each with fundamentally different natures and origins that create the foundation of conscious experience. The Asymmetrical Genesis: The framework posits that Life begins with the first breath, the initial spark of consciousness—marking the first point on its rope. Time, conversely, originates from an unseen place, potentially from Life's completion, creating a mysterious cosmic loop that challenges linear temporal assumptions. This asymmetrical beginning establishes the foundational tension that drives all temporal experience. Dynamic Point Intersections: At every moment of existence, individual points of Life meet corresponding points of Time, yet these intersections are not fixed alignments. The theory demonstrates that when consciousness intensifies—when souls burn bright through purposeful action—subjective time accelerates while universal "meridian time" maintains its steady flow. This creates personalized temporal experiences where individuals operate on private clocks that deviate from collective chronometry based on the intensity of their existential engagement. Relativistic Life-Time Dynamics: Drawing parallels to Einstein's relativity, the theory proposes that each life forms its own temporal reference frame. Two individuals sharing the same objective moment may experience radically different temporal flows based on their Life-Time connection intensity. This establishes a new form of temporal relativity where consciousness, rather than velocity, becomes the primary factor in time dilation. Cosmic Entanglement Mechanics: The ropes of Life and Time exist in quantum-like entanglement, functioning as two threads in a cosmic braid. Life chooses direction and meaning, while Time serves as the recording mechanism, the cosmic canvas upon which Life paints its journey. The faster Life pulls forward through purposeful action, the more Time responds by stretching, bending, and adjusting its flow—creating a dynamic feedback loop between existence and temporality. Circular Temporal Architecture: The theory suggests a profound circular relationship between beginnings and endings. Life may start where Time waits in anticipation, while Time concludes where Life completes its path. This creates a breathing relationship where one rope gives meaning to the other, establishing existence as a collaborative dance between temporal flow and conscious experience. Individual Temporal Sovereignty: The framework's revolutionary conclusion asserts that humans are not passive participants living within time, but active creators of their own temporal reality. Each soul operates on its own rope of Time, uniquely connected to its Life journey. The intensity of purpose, the depth of awareness, and the brightness of existential engagement determine how dramatically one's private clock diverges from universal temporality. This establishes the concept of temporal sovereignty—the ability of consciousness to govern its own temporal experience within the broader cosmic framework. Implications for Consciousness Studies: The Twin Ropes Theory offers profound implications for understanding consciousness, suggesting that temporal experience is not merely subjective perception but an active creation of reality through the entanglement of Life and Time. This framework provides new perspectives on flow states, mindfulness, purposeful living, and the relationship between meaning-making and temporal experience, potentially bridging metaphysical philosophy with practical applications in psychology, neuroscience, and existential therapy
Solving the Quantum Heisenberg model with neural-network quantum states
No full textSolving quantum many-body systems is a fundamental challenge in physics. Traditional computational methods often struggle to solve them due to the exponential growth of the system’s Hilbert space. In recent times, Neural-Network Quantum States (NNQS) has emerged as a promising tool to approximate quantum wave functions based on machine learning methodologies. Using machine learning enables efficient computation of high-dimensional quantum systems which are otherwise unfeasible to compute. This work investigates two foundational models in quantum mechanics: One dimensional transverse field Ising and Heisenberg model, and predicts the expected energies and other properties with the help of machine learning.
To implement the NNQS, predefined neural network functions from the NetKet library is used. The methodology uses Monte Carlo sampling techniques along with gradient descent optimizer to find the approximate solution. Using these methods we predict the ground state energy, magnetization and magnetic susceptibility in transverse and longitudinal fields for each of the Ising system and the Heisenberg system.
Later, the Barren Plateau is also investigated. In a Barren plateau, gradient based optimization methods struggle to find the optimal solution. In this work, this was a significant problem to reach the approximate solution. Lastly, the results are attached after which we summarize our findings and compare the methodologies and give a final reflection on the work
???? The Twin Ropes of Time and Life
No full textThis paper presents the Twin Ropes Theory, a comprehensive metaphysical framework that revolutionizes our understanding of temporal existence through the lens of parallel dimensional constructs. The theory conceptualizes Time and Life as two infinite ropes stretching through the fabric of existence, each with fundamentally different natures and origins that create the foundation of conscious experience. The Asymmetrical Genesis: The framework posits that Life begins with the first breath, the initial spark of consciousness—marking the first point on its rope. Time, conversely, originates from an unseen place, potentially from Life's completion, creating a mysterious cosmic loop that challenges linear temporal assumptions. This asymmetrical beginning establishes the foundational tension that drives all temporal experience. Dynamic Point Intersections: At every moment of existence, individual points of Life meet corresponding points of Time, yet these intersections are not fixed alignments. The theory demonstrates that when consciousness intensifies—when souls burn bright through purposeful action—subjective time accelerates while universal "meridian time" maintains its steady flow. This creates personalized temporal experiences where individuals operate on private clocks that deviate from collective chronometry based on the intensity of their existential engagement. Relativistic Life-Time Dynamics: Drawing parallels to Einstein's relativity, the theory proposes that each life forms its own temporal reference frame. Two individuals sharing the same objective moment may experience radically different temporal flows based on their Life-Time connection intensity. This establishes a new form of temporal relativity where consciousness, rather than velocity, becomes the primary factor in time dilation. Cosmic Entanglement Mechanics: The ropes of Life and Time exist in quantum-like entanglement, functioning as two threads in a cosmic braid. Life chooses direction and meaning, while Time serves as the recording mechanism, the cosmic canvas upon which Life paints its journey. The faster Life pulls forward through purposeful action, the more Time responds by stretching, bending, and adjusting its flow—creating a dynamic feedback loop between existence and temporality. Circular Temporal Architecture: The theory suggests a profound circular relationship between beginnings and endings. Life may start where Time waits in anticipation, while Time concludes where Life completes its path. This creates a breathing relationship where one rope gives meaning to the other, establishing existence as a collaborative dance between temporal flow and conscious experience. Individual Temporal Sovereignty: The framework's revolutionary conclusion asserts that humans are not passive participants living within time, but active creators of their own temporal reality. Each soul operates on its own rope of Time, uniquely connected to its Life journey. The intensity of purpose, the depth of awareness, and the brightness of existential engagement determine how dramatically one's private clock diverges from universal temporality. This establishes the concept of temporal sovereignty—the ability of consciousness to govern its own temporal experience within the broader cosmic framework. Implications for Consciousness Studies: The Twin Ropes Theory offers profound implications for understanding consciousness, suggesting that temporal experience is not merely subjective perception but an active creation of reality through the entanglement of Life and Time. This framework provides new perspectives on flow states, mindfulness, purposeful living, and the relationship between meaning-making and temporal experience, potentially bridging metaphysical philosophy with practical applications in psychology, neuroscience, and existential therapy
Rheological Modelling and Simulations of Dilute Polyelectrolyte Solutions in Complex Geometries
No full textDilute polyelectrolyte solutions show viscoelastic behaviour different from solutions of uncharged polymers by virtue of the additional stiffness provided by the repulsion between charges on the polymer chain and screening of the charged sites by ionic species in the system. Experiments report an increase in chain extensions and polymeric viscosities due to the charged nature of the polymers. These effects impact the macroscopic flow behaviour of polyelectrolytes in complex geometries. In this work, we have developed a theoretical model describing the viscoelastic behavior of dilute polyelectrolyte (PE) solutions using Onsager’s variational principle. The PE molecules are described as finitely extensible charged dumbbells suspended in a solvent containing ionic species which screen the charged sites on the macromolecules. We first formulate the rheological model in a conformation tensor formalism and couple it to the steady Stokes equations to simulate the flow of dilute polyelectrolyte solutions in confined geometries. Our results indicate an increase in the drag experienced by the bodies in a flowing PE solution, increased pressure drops and normal stresses with increasing molecular charge density. Next, the model is reformulated to consider stress induced inhomogeneities in the system and the effect of counterion fluctuations on molecular migration of polyelectrolytes is investigated. We conclude that our model based on a simple charged dumbbell with counterion screening, together with Onsager’s variational principle is a powerful tool to investigate the dynamics of dilute polyelectrolyte solutions and the effects of the polyelectrolyte charge and solvent salinity
A study on the acceptability of N95 respirators among private medical practitioners during COVID 19 pandemic
No full textOn March 11, 2020, the novel coronavirus was declared pandemic. Use of N95 respirators is proven to be one of the most important methods to prevent the spread of disease. This study was conducted to know the pattern of adherence and discomfort faced by N95 respirators or masks among private medical practitioners in a city of West Bengal, India during the period of COVID-19 pandemic. We found 58% doctors were not using N95 respirators for the whole time during duty. We also found different sections of respondents like age less than 60 years, unmarried / divorced/separated/widow marital status, absence of children in family, surgical work field area and duty shift more than 8 hours have statistically significant association with irregular use or non-use of N95 respirators. Major discomfort of N95 respirators came out as shortness of breath (57%) and hot humid feeling (55%). In conclusion the study suggests behavior change communication and application of rules and regulation by government to solve these problems
A study on the safety and tolerability of mycophenolate mofetil in patients with connective tissue disease
No full textBackground: Connective tissue disorders (CTD) are mostly due to inflammatory and fibrotic tissue injury. Glucocorticoids and immunomodulators though useful but are toxic. Mycophenolate mofetil (MMF) is now being used successfully in many autoimmune diseases, but the safety of MMF in CTD patients is yet to be conclusively established.Methods: The study was a retrospective record based observational one in patients of CTD satisfying the predetermined inclusion criteria. Various safety parameters were noted down from the observed records and analysed accordingly.Results: The 120 case records of CTD patients were analysed for a specific set of safety parameters over the preceding one year. Diarrhoeal attacks were the most commonly encountered side effect (38.3%) of long term patients who were on mycophenolate therapy followed by infection.Conclusions: Mycophenolate was found to be generally well tolerated in CTD patients with few reports of adverse events, but larger clinical trials are needed to conclusively establish its safety
A real world STudy of ADherence to Insulin in diabetic hUMans-STADIUM study
No full textBackground:
With an ever-increasing prevalence of diabetes, lack of adherence to insulin treatment in even a small percentage of patients is a major issue and can lead to significant burden on the healthcare system. This survey analysis seeks to investigate the insulin adherence patterns to identify the factors associated with medication adherence.
Methodology:
The current cross-sectional survey was conducted among diabetes patients on insulin treatment. A list of questions about insulin adherence was provided to the participants in the study and the responses were recorded. The data was analysed using Graph Pad Prism.
Results:
Around 23.2 and 18.6 % of patients denoted missing their insulin treatment occasionally and kept no tab on their adherence respectively. Further, upon questioning on their adherence, 19.4% and 20.4% denoted missing their insulin injections weekly and monthly respectively. Among the reasons for missing injections, 20.3% mentioned forgetfulness, around 40% mentioned negligence as a reason, and 17.2% avoided insulin injections while feeling sick and better respectively. Among the study participants, around 46% ran out of refills, with 88% of them missing their refills due to forgetfulness. Increasing age (P = 0.0024), female gender (P = 0.0009), elevated HbA1c levels (P = 0.0058), Higher BMI levels (P
Conclusion:
Around 42% of the participants missed their insulin injections frequently or kept no tab. Age, gender, insurance status, and glycaemic control have been observed to impact adherence behaviour. Support program focusing on improved education, understanding, and addressing their concerns could facilitate improved adherence among a sub-set of population
Short-chain n-alkanes in benthic mats and mosses from the Larsemann Hills, East Antarctica
No full textVariation in leaf colour (green, red and grey) of mosses and lake benthic mats in Antarctica is often linked to water stress and ultraviolet light (UV-B) exposure. Changes in the abundance of organic compounds, such as pectin and phenols, are associated with mechanisms protecting against desiccation and UV radiation. However, the function of n-alkanes, especially against UV radiation, is rarely examined. Here, gas chromatography–mass spectrometry and Fourier-transform infrared spectroscopy analyses were performed to study the variation in n-alkanes in freshwater lake benthic mats and mosses collected from the Larsemann Hills in East Antarctica. Stable isotopes of organic carbon and nitrogen, environmental DNA characterisation and microscopy-based analyses are used to estimate the presence of cyanobacteria, algae and diatoms in moss and benthic mat consortia. Variation in the short-chain (n-C17 to n-C20) versus long-chain (n-C21 to n-C30) n-alkanes in the mosses and benthic mats with their colour were noted. The research links the relative abundance of short-chain n-alkanes to the UV-B exposure and proposes that Antarctic mosses and benthic mats synthesise short-chain n-alkanes for protection against UV-B.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Sanitary Engineerin
Empowering Librarians with Data: A Comparative Analysis of Data Warehousing Tools
No full text42-49In the face of exponential data growth, libraries grapple with effectively managing and extracting knowledge from massive datasets. Data warehousing technologies have emerged as indispensable tools to address this challenge. This research investigates the significance of data warehousing within the library domain, focusing on its capacity to streamline data management and analysis processes. A comparative assessment of ten prominent data warehousing platforms is conducted, including Teradata Vantage, OCLC WorldShare Analytics, Snowflake, Amazon Redshift, IBM Db2 Warehouse, Alma, Oracle Autonomous Data Warehouse, SAP Data Warehouse Cloud, Microsoft Azure Synapse Analytics, and Google BigQuery. This evaluation scrutinizes crucial aspects such as architectural design, user-friendliness, applicability within library contexts, security mechanisms, distinctive features, and, crucially, cost-effectiveness. Particular emphasis is placed on identifying solutions that harmonize functionality with the budgetary realities of library operations. The study elucidates the strengths and shortcomings of each platform, providing actionable guidance for libraries to select the most suitable data warehousing solution based on their unique operational requirements and financial limitations. This research underscores the imperative of adopting a suitable data warehousing tool to augment data management and analytical capabilities within libraries, thereby facilitating informed decision-making and enhancing service delivery
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