50 research outputs found
Strukturierung von Wissensdomänen mit Hilfe von XML Topic Maps (XTM 1.0) am Beispiel von Lehrmaterialien für Fh/IGD
No full textIm Verlaufe dieser Arbeit wurde ein Grundkonzept für die Wissensstrukturierung einer ausgewählten Wissensdomäne "Lerndomäne Fh-IGD" entwickelt. Dabei wurden die allgemeinen Erwartungen an einer Lerndomäne aus der Lernersicht untersucht. Auf Basis dieser Anforderungen wurden drei Teilkonzepte dieser Domäne herausgebildet, die später in einem semantischen Netz zusammengesetzt wurden. Aus einem Teil des erstellen Netzes ("Kurskatalog") wurde mit Hilfe von XTM-Standards eine Topic Map anhand einer Beta Release Version von "emplolis K42" aufgebaut, in der alle Objekte des Netzes mit deren Beziehungen berücksichtigt sind. Diese Map wird einem Lerner helfen um die bestimmten und gezielten Informationen im Lernsystem zu finden, indem er innerhalb einer dynamischen Navigationssystem forschen kann. Für den Aufbau dieser Map wurden drei Hauptkomponenten des K42 verwendet. Diese Komponenten stehen jedem Designer oder Editor zur Verfügung. - Mit dem Web Author wurde eine Map-Struktur (TM Template) für das Teilkonzept "Kurskatalog" erstellt. - Mit TMM (Topic Map Manager) wurde die TMT unter einer XML-Datei gespeichert oder beim Bedarf aufgerufen. - Aus dem vorhandenen Topic Map Template generierte das Tool automatisch in Topic Map View einen Navigationsbaum. Der Baum zeigt dem Benutzer die visuelle Darstellung der Konzeptstruktur und erlaubt ihm innerhalb dieser Sicht zu navigieren. Um die Anwendung des entwickelten System überschaubar zu machen, wurden zum Schluß einige Instanzen als reale Topics in der ganzen Map definiert. Während dieser Arbeit wurde versucht um die Eigenschaften sowie die Schwäche und Stärke des Tool zu herausfinden und anhand seiner vorhandenen Fähigkeiten eine entsprechende Map aufzubauen
Evaluation for the transport situation & the energy demand for northern Christchurch, New Zealand
No full textThis paper reviews the transport situation in the northern sector of the greater
Christchurch area, in New Zealand. It provides an overview of the specific geographical
situation, highlighting the land use and allowing a good understanding of the modal choices of
commuters. Its focus is on the commuter traffic situation in this area of increased low-density
residential development, assessing whether residential living on large sections of land is
sustainable long-term with peak-oil in the background. The study evaluates traffic data reports
and surveys that deal with southbound traffic, including assessing the public transport option.
The data is assessed in terms of consistency and checked against other available information. The
analysis outlines the importance of consistency when collecting transport data to ensure coherent
decision-making.
The approximate energy demand for commuting from Rangiora to Christchurch is calculated
using a simulation model developed by the author based on available data
Performance of the revised Bethesda guidelines for identification of colorectal carcinomas with a high level of microsatellite instability
No full textContext. - Criteria for microsatellite instability (MSI) testing to rule out hereditary nonpolyposis colorectal cancer were recently revised and include parameters such as age and specific histologic features that can be identified by the pathologist, triggering reflex MSI testing. Objective. - To review the performance of the revised Bethesda guidelines to identify MSI-positive colorectal cancers. Design. - Seventy-five patients with colorectal cancer were included; 68 patients younger than 50 years and 7 patients between 50 and 60 years were selected based on histopathologic criteria. Microsatellite instability testing with the National Cancer Institute-recommended panel and immunohistochemistry for hMLH1 and hMSH2 were performed. Tumors were classified into microsatellite instability high (MSI-H), low (MSI-L), or stable (MSS) categories. Results. - Overall, 17 (23%) of 75 colorectal cancer cases were classified as MSI-H, including 13 patients younger than 50 years and 4 patients between 50 and 60 years. Among the MSI-H tumors, 10 (59%) were characterized by loss of hMLH1 and 6 (35%) were hMSH2 negative. Histologic features suggestive of MSI-H phenotype were present in 80% of MSI-H and 35% of MSS/MSI-L tumors. The number of positive lymph nodes was higher in MSS/MSI-L adenocarcinomas (P = .04). Conclusions. - By selecting for age and histologic features, we detected MSI-H tumors in approximately one quarter of colorectal cancer cases meeting the revised Bethesda guidelines and identified 17 MSI-H cases, whereas only 8 would have been recognized by the prior guidelines. These data indicate that reflex testing requested by pathologists based on the revised Bethesda guidelines increases the detection of MSI-H and potential hereditary nonpolyposis colorectal cancer cases
Analysis of genomic instability using multiple assays in a patient with Rothmund-Thomson syndrome
No full textWe report on a patient with Rothmund-Thomson syndrome (RTS) whose cytogenetic evaluation showed a normal karyotype with no evidence of trisomy mosaicism or chromosomal rearrangements. Cultured lymphocytes from the patient, her mother, and a control exposed to mitomycin C and diepoxybutane did not show increased sensitivity to the dialkylating agents. Unlike some previous reports, we found no evidence of a deficiency in nucleotide excision repair, as measured with the functional unscheduled DNA synthesis assay. Glycophorin A analysis of red blood cells for somatic mutation revealed suspiciously high frequencies of both allele loss and loss-and-duplication variants in the blood of the patient, a pattern consistent with observations in other RecQ-related human diseases, and evidence for clonal expansion of a mutant clone in the mother. Discrepant results in the literature may reflect true heterogeneity in the disease or the fact that a consistent set of tests has not been applied to RTS patients
Learning Experience Design and Unpacking Sociocultural, Technological, and Pedagogical Design Considerations of Spherical Video-Based Virtual Reality Systems for Autistic Learners: A Systematic Literature Review
No full textThis systematic literature review discusses the use of spherical video-based virtual reality (SVVR) as a training and therapy intervention for autistic individuals. The authors emphasize the need for an evidence-based framework with guidelines and design considerations to help developers and educators tailor SVVR to the diverse needs of autistic learners. The paper highlights the unique benefits of SVVR, such as being relatively easier to develop compared to other VR technologies and high compatibility with various devices, making it more affordable for educational settings. The authors also discuss the importance of the STP (Sociotechnical-Pedagogical) framework for evaluating and designing social aspects of SVVR interventions for autistic individuals. [Abstract copyright: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Genotype-phenotype correlations of pheochromocytoma in two large von Hippel-Lindau (VHL) type 2A kindreds with different missense mutations
No full textComparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC)
No full textAbstract: We have compared outcomes, including the locoregional recurrence, between mastectomy and breast conserving therapy in PABC. Patients were divided into those who were treated with mastectomies (group 1) and those with breast conserving surgery (group 2). The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1. Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10 % vs
Long-term outcomes, branch-specific expressivity, and disease-related mortality in von Hippel-Lindau type 2A
No full textAuthor Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
No full textA Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4
