63,145 research outputs found
L'egloga rappresentativa nel Quattrocento: un'ipotesi storiografica?
No full textIl contributo prende in esame le esili tracce quattrocentesche dell'egloga rappresentativa in lingua volgare
Nuove carte Baretti all'Ambrosiana
No full textLo studio dei materiali autografi e apografi raccolti nel Fondo Baretti della Biblioteca Ambrosiana di Milano ha permesso di chiarire la genesi e l'elaborazione delle Lettere familiari di Giuseppe Baretti (Londra 1779), una delle opere italiane più fortunate in Europa nella seconda metà del Settecento. L'analisi ha inoltre permesso si chiarire i modi e le ragioni dell'intervento del bibliofilo Pietro Custodi che intervenne sul testo procurando una diversa stampa
A numerical micro-mechanical study on damage induced by the curing process in carbon/epoxy unidirectional material
No full textA numerical framework for the determination of the damage, the stress and the inelastic strain field induced by the curing process for unidirectional carbon/epoxy composite material is proposed. The approach integrates a network model for the estimation of the matrix shrinkage and elastic properties evolution during curing with damageable elasto-plastic constitutive equations. Simulations of the curing process and of the cured material transverse mechanical response are carried out. A sensitivity study is realised for different volume fractions and matrix tensile strengths for single fiber models. Analyses of Representative Volume Elements (RVEs) with randomly distributed fibers are also performed and a comparison with the ideally cured version of the same model is used to highlight the importance of considering the curing process effects in micromechanical models. The proposed framework, with a proper calibration of the constituents, contributes to the enhancement of the fidelity of numerical micromechanics for this class of materials
Multidisciplinary management for early diagnosis of prosthetic joint infection: our experience
No full text
Intravitreal Bevacizumab versus Low Fluence Photodynamic Therapy for the treatmentof Chronic Central Serous Chorioretinopathy
No full textAbstract
PURPOSE:
To report the effectiveness and safety of intravitreal bevacizumab injection (IVB) compared with low-fluence photodynamic therapy (L-PDT) in eyes with chronic central serous chorioretinopathy (CSC).
METHODS:
This was a prospective comparative interventional study of 22 patients affected by chronic CSC. Patients were randomly assigned to group 1 (12 patients treated with 1.25 mg IVB) and group 2 (10 patients treated with L-PDT). In group 2, PDT with verteporfin was delivered at low fluence (300 mW/cm(2) for 83 s, 25 J/cm(2)). Follow-up visits were scheduled at 1, 3, 6, and 9 months.
RESULTS:
The improvement in visual acuity was greater in group 1 than in group 2, although the difference was not statistically significant (P = 0.59). The mean change in central point thickness over 9 months from baseline was 127 μm (SD 36) in group 1 and 114 μm (SD 42) in group 2. After the first injection, retreatments were given if recurrence was noted, with an average of 3.0 ± 1 injections in group 1 and 1.6 ± 0.6 treatments with L-PDT in group 2. The difference between retreatment in the 2 groups was not statistically significant (P = 0.45).
CONCLUSIONS:
Based on the results obtained after 9 months of follow-up, our study provides evidence that IVB may be a treatment option for chronic CSC
Diagnosis, management and outcome of clinically-suspected spinal infection
No full textObjectives: Spontaneous spinal infection (SI) is a quite rare but serious entity. This
study aimed to evaluate outcome and follow-up data of SI cases without a microbiological
diagnosis (suspected SI).
Methods: We undertook a retrospective, comparative study of 82 spontaneous SI cases in
adults presenting over an 11-year period to two Italian hospitals.
Results: The diagnostic yields of blood culture, percutaneous needle biopsy of spine, and surgical
sample culture were 43.6%, 72.7%, and 91.6%, respectively. Overall, causative organisms
were identified in 60 (73.2%) cases, the most frequently isolated pathogens being Staphylococcus
aureus and Mycobacterium tuberculosis. The median diagnostic delay was similar
(pZ0.39) in pyogenic (1 month) and suspected (0.5 month) SI cases, and longer in tuberculous
cases (4 months) than in the other SI case groups (pZ0.069 and pZ0.062, respectively). All
patients received antibiotic treatment, and 21 (25.5%) underwent surgery, that was required
more frequently in tuberculous (40.7%) than in pyogenic (25.0%) and suspected SI cases
(9.1%) (pZ0.028). Of 67 patients who completed a 1-year follow-up period, 24 had persisting
painful disability that was more frequent in tuberculous (66.7%) cases than in pyogenic (21.7%)
and suspected SI (15.0%) cases (pZ0.03).
Conclusions: Although a microbiological diagnosis was not achieved in nearly a quarter of SI
cases, both diagnostic delay and outcome were similar to those of pyogenic SI cases. Earlier
recognition of tuberculous SI is mandatory, as this is associated with the highest long-term
morbidit
Effect of Combined Bevacizumab and Photodynamic Therapy at Reduced Light Fluence Rate in the Treatment of Choroidal Neovascularization Secondary to Pathologic Myopia
No full textARVO 200
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