190 research outputs found
Essays on Plato's epistemology
No full textThrough a careful survey of several significant Platonic texts, mainly focussing on the nature of knowledge, Essays on Plato’s Epistemology offers the reader a fresh and promising approach to Plato’s philosophy as a whole. From the very earliest reception of Plato’s philosophy, there has been a conflict between a dogmatic and a sceptical interpretation of his work and thought. Moreover, the two sides are often associated, respectively, with a metaphysical and an anti-metaphysical approach. This book, continuing a line of thought that is nowadays strongly present in the secondary literature – and also followed by the author in over thirty years of research –, maintains that a third way of thinking is required. Against the widespread view that an anti-dogmatic philosophy must go together with an anti-metaphysical stance, Trabattoni shows that for Plato, on the contrary, a sober and reasonable assessment of both the powers and limits of human reason relies on a proper metaphysical outlook
Comparison of the Effectiveness of Percutaneous Intervention of the Left-Main Coronary Artery With Everolimus-Eluting Stents in Women -Vs- Men
No full textEverolimus-eluting stents are largely used for left main (LM) percutaneous coronary interventions (PCI) . Long-term follow-up of patients undergoing LM PCI in a real world clinical setting, in particular women, have been scarcely reported. Consecutive patients undergoing unprotected LM PCI with EES at a single Institution from December 2006 to April 2016 were included. Main outcome assessed was the occurrence of major adverse cardiovascular events (MACE) as a composite of death, myocardial infarction or target lesion revascularization at follow-up. Overall, 589 patients (20.8% women), were included in the present analysis. Women were older, had lower BMI and more frequently hypertensive compared to men. Main clinical presentation was stable CAD; unstable angina was more frequently observed in women compared to men, whereas STEMI was less frequent. After 69.7 ± 28.3 months of follow-up, 47 patients overall experienced MACE (1.43 per 100*patients/year). MACE rate was higher in female compared to male patients, with a rate of 2.49 and 1.17 per 100*patients/year, respectively (P=0.015). The difference was driven mainly by higher mortality in women (0.89 vs. 0.15 per 100*patients/years, P=0.002). At multivariable Cox regression, female gender was independently associated with an increased risk of MACE at follow-up (HR 2.21, 95% CI 1.20 – 4.08, P=0.011). In conclusion, EES can be safely and effectively adopted for LM PC
Xience stent single-center registry
No full textABSTRACT
Background: Safety and effectiveness of the everolimus-eluting stent (EES) have been previously demonstrated.
Aims: To assess very long-term performance and outcomes of the EES in a real-world population. Methods: This single-center registry prospectively enrolled 6,893 patients (mean age 66±9.7 years, 81.4% men) undergoing elective coronary intervention with the EES over a decade. Clinical follow-up (FU) was performed at 1 year and then yearly.
Results: Multiple risk factors were present in 34%. Stable angina was the main stenting indication (78.1%), followed by unstable angina (5.3%) and positive stress test (16.6%) for 1- (44%) or 2/3-VD (56%). Multiple stents (stent/patient ratio: 2.1±0.8) in >1vessel were implanted in 36.9% (mean stent length=43±31.3 mm). At 1 year, 80% of patients were on dual antiplatelet therapy, while 3% only at 2 years. A low (5%) 1-year MACE rate was observed; ST occurred in 19 (0.3%) patients with a prevalence of early (9) over late (4) and very late (6) (0.08%) events. Clinically driven TLR/TVR occurred in 3.3% at 1-year follow-up. Long-term FU (3 years) completed in 6210 (90%) patients showed a 5.9% MACE rate, while very long-term (>5 years and up to 10 years) follow-up, available in 3550 out of 4635 exposed patients (72%), showed an 8.6% MACE rate. Independent MACE predictors were stented segment length (OR: 2.1; 95% CI:1.57-2.82), small vessel stenting (OR: 1.34;95% CI: 1.08-1.68) and multivessel disease (2VD, OR:1.59; 95% CI: 1.21-2.08; 3VD, OR: 2.26; 95% CI: 1.72-2.97).
Conclusions: This large prospective registry confirms the very long-term safety and efficacy of the EES in unselected real world and complex coronary lesions
Is the Sirolimus encapsulated balloon a reliable tool for treating the in-stent restenosis?-insights from the SABRE trial
No full textChe ruolo giocano le matematiche nella metafora della linea?
No full textThe paper investigates a section of the so called metaphor of the «divided line» (Republic, 510b2-511b11). First, a new translation of the first lines of the text is proposed, on the basis of the Sling's recent edition and with slight modification of the punctuation. Secondly, the author argues that the reference of the mathematics and of the geometrians' methods has to be regarded not so much as if Plato was actually criticizing them, but as a telling example of the incorrect way of understanding intellectual cognition. This incorrect way of knowing consists in claiming to grasp the ideas through an intellectual insight fashioned on the model of sensible vision. It is incorrect because according to Plato human insight cannot be but sensible. Such a conclusion confirms the hypothesis, endorsed by several scholars, that according to Plato even the highest kind of cognition that human beings dispose of is not intuitive but discursive
Essays on Plato’s Epistemology
No full textThrough a careful survey of several significant Platonic texts, mainly focussing on the nature of knowledge, Essays on Plato's Epistemology offers the reader a fresh and promising approach to Plato's philosophy as a whole. From the very earliest reception of Plato's philosophy, there has been a conflict between a dogmatic and a sceptical interpretation of his work and thought. Moreover, the two sides are often associated, respectively, with a metaphysical and an anti-metaphysical approach. This book, continuing a line of thought that is nowadays strongly present in the secondary literature -- and also followed by the author in over thirty years of research -- maintains that a third way of thinking is required. Against the widespread view that an anti-dogmatic philosophy must go together with an anti-metaphysical stance, Trabattoni shows that for Plato, on the contrary, a sober and reasonable assessment of both the powers and limits of human reason relies on a proper metaphysical outlook.Includes bibliographical references and index.Introduction -- 1. Thought as inner dialogue (Theaet. 189e4-190a6) -- 2. Logos and doxa : the meaning of the refutation of the third definition of epistêmê in the Theaetetus -- 3. Theaetetus 200d-201c : truth without certainty -- 4. Foundationalism or coherentism? On the third definition of epistêmê in the Theaetetus -- 5. What is the meaning of Plato's Theaetetus? Some remarks on a new annotated translation of the dialogue -- 6. David Sedley's Theaetetus -- 7. The "virtuous circle" of language. On the meaning of Plato's Cratylus -- 8. The knowledge of the philosopher -- 9. What role do the mathematical sciences play in the metaphor of the line? -- 10. Socrates' error in the Parmenides -- 11. On the distinguishing features of Plato's "Metaphysics" (starting from the Parmenides) -- 12. Is there such a thing as a "Platonic theory of the ideas" according to Aristotle? -- 13. The unity of virtue, self-predication and the "third man" in Protagoras 329e-332a -- 14. Plato : philosophy, politics and knowledge. An overview.Through a careful survey of several significant Platonic texts, mainly focussing on the nature of knowledge, Essays on Plato's Epistemology offers the reader a fresh and promising approach to Plato's philosophy as a whole. From the very earliest reception of Plato's philosophy, there has been a conflict between a dogmatic and a sceptical interpretation of his work and thought. Moreover, the two sides are often associated, respectively, with a metaphysical and an anti-metaphysical approach. This book, continuing a line of thought that is nowadays strongly present in the secondary literature -- and also followed by the author in over thirty years of research -- maintains that a third way of thinking is required. Against the widespread view that an anti-dogmatic philosophy must go together with an anti-metaphysical stance, Trabattoni shows that for Plato, on the contrary, a sober and reasonable assessment of both the powers and limits of human reason relies on a proper metaphysical outlook
When a patent foramen ovale device is no more in place: silent patent foramen ovale occluder device migration to the aortic arch
No full textEarly stent thrombosis after superficial femoral artery stenting successfully treated with transcatheter rheolytic thrombectomy in a patient with reduced aspirin responsiveness
No full textAbstractPurposeTo describe a case of early superficial femoral artery (SFA) thrombosis after stenting in an aspirin low-responsive patient successfully treated with percutaneous mechanical thrombectomy.Clinical and interventional summaryEarly SFA stent thrombosis occurred in a 65-year-old man treated with multiple stent implantation for chronic total occlusion of the left SFA. The potential cause for thrombosis was a suboptimal PTA [percutaneous transluminal angioplasty] result characterized by no-flow limiting residual linear dissection left untreated and which was associated with low responsiveness to aspirin. Rapid thrombus removal and flow restoration were obtained with the Angiojet Ultra Thrombectomy System (Medrad, Warrendale, PA, USA).ConclusionsTreatment of SFA stent thrombosis should be undertaken with the understanding of the underlying thrombotic causes and the knowledge of the most appropriate therapeutic options. A percutaneous mechanical strategy with the Angiojet Ultra Thrombectomy System may achieve rapid and complete recanalization even in the presence of huge thrombotic burden.<Learning objective: New devices have been available for huge thrombotic burden management in acute clinical peripheral settings. A few clinical experiences have been described and the case we present shows the safety and efficacy of the rheolytic thrombectomy for femoral stent thrombosis management avoiding bleeding and distal embolization risks.
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