55 research outputs found
Impact of insulin glargine on metabolic control and on occurrence of severe hypoglycemia in type 1 diabetic children and adolescents in the last three years
No full textPsychological problems in diabetic children and adolescents are related to disease duration and metabolic control: a study with children and parent questionnaires
No full textGastrointestinal lesions in parvovirus B19 infection
No full textA 13-year-old girl with persistent fever, pharyngitis, acute anaemia, peripheral blood and bone marrow positive for parvovirus B19 DNA.Microscopic findings of gastrointestinal biopsy showed diffuse vacuolar alteration of the cytoplasma of duodenal enterocytes and virological analysis demonstrated the presence of parvovirus in lymphocytes of the duodenal wall's epithelial layer.In unexplained gastrointestinal pathologies, the role of parvovirus B19 infection should be investigated
Quality of life, psychological adjustment and metabolic control in youths with type 1 diabetes: a study with self- and parent-report questionnaires.
No full textAge at onset do not influence long-term glycemic control in children with type 1 diabetes mellitus
No full textBackground. Studies indicate that younger patients show a significantly lower C-peptide secretion and a more difficult metabolic control at onset and during the first years after the diagnosis of type 1 diabetes mellitus. It is not so clear whether these differences persist also after a higher number of years
of disease duration and whether they may justify the different results obtained by the new therapeutic regimens in the various period of life. Objective. To compare, at 1, 3 and 5 years of disease, metabolic control, C-peptide levels and insulin-dose requirement in two groups of children, who developed type 1 diabetes between 1994 and 2002: Group 1 (n. 42) with onset before the age of 5 yrs (n.22 < 3 yrs) and Group 2 (n.38) with onset after the age of 10 years. N. 73 have completed a 3 year and n. 55 a 5 year follow-up. All patients of Group 2 were pubertal at the end of follow-up.
Results. At 1 and 3, but not 5 years of disease, the percentage of cases with detectable levels of C-peptide and mean C-peptide values were significantly higher in Group 1 than in Group 2. C-peptide levels correlated significantly with age at onset at all times considered. On the contrary, the age at onset correlated with HbA1c mean levels and insulin-dose requirement only after 1 yr, and mean annual HbA1c values were not significantly different in the two groups at any time of follow-up. These HbA1c values were again similar, even if we considered only the cases, in the two groups, with undetectable Cpeptide.
Conclusions: Age at onset and a good preserved residual beta-cell function are unable, years after the onset of the disease, to influence the long-term glycemic control. It should be remembered, however, that this comparison is not wholly homogeneous, since, obviously, only Group 2 is influenced by puberty, another variable with a strong effect on metabolic control
Growth and adult height in atypical coeliac patients, with or without growth hormone deficiency.
No full textOBJECTIVE: To evaluate the effect of a gluten-free diet on growth and adult height, when available, in coeliac children without gastrointestinal symptoms. PATIENTS AND METHODS: Sixty-one coeliac children without gastro-intestinal symptoms were included in the study. The age at diagnosis was 9.50 +/- 3.3 years. Thirty-eight had short stature at diagnosis (< 10th percentile) and 23 had normal stature. Thirty-seven reached adult height. RESULTS: After beginning the diet an increase in growth velocity was seen in 30 patients (responders) (20 with initial short stature), while in 31 patients (18 with short stature) there was no catch-up growth (non-responders). Bone age at diagnosis was significantly more delayed in the responders than in the non-responders. Target height was significantly higher in children with normal stature at diagnosis than those with short stature. Growth hormone (GH) deficiency was found and confirmed after 6-12 months of diet in 12 of the 38 patients (32%) with short stature. In the group of the 30 'short' patients who attained final height, target height was attained or improved in 12 patients (40%): in eight of the 16 (50%) responders and in four of the 14 (29%) non-responders; in eight (all responders) out of 22 (36%) without GH deficiency, and in four out of eight (50%) patients with GH deficiency treated with GH (all non-responders). CONCLUSIONS: In children in whom coeliac disease is diagnosed because of short stature, a gluten-free diet will be successful if at diagnosis there is a delay of bone age and in the first year of diet there is an evident catch-up growth. When this does not occur, i.e. in half of the patients (18 out of 38), it may be because of an associated and transient GH deficiency. In these patients a period of GH replacement therapy as well as a gluten-free diet may improve their final height
A case of furuncular myiasis associated with systemic inflammation
No full textCutaneous myiasis is a common travel-associated dermatosis caused by fly larvae. We report an unusual case of furuncular myiasis caused by Dermatobia hominis that was associated with signs of systemic inflammation. In this case study, morphological and novel molecular approaches were used to identify and characterize the larvae responsible for human infestation
Follow-Up of Homocysteine, Folate and Vitamin B12 in Children and Young Adults with Type 1 Diabetes Mellitus
No full textIt is far from clear whether hyperhomocysteinemia (HH(e)), when present, is a preexisting marker for diabetic patients predisposed to vascular complications or an acquired condition that may change over time. To try to clarify this question we examined in two different moments, after 2 years or more, a group of 46 diabetic
children and young adults. Age at entry ranged between 4.25 and 28.5 years, mean duration of disease was 10.9 ±4.6 years and mean HbA1c value 8.3±1.6%. In all patients in both examinations we assessed basal homocysteine (H(e)), folate, vitamin B6 and vitamin B12 levels. Total, free + protein-bound, plasma H(e) level were measured by HPLC. Results: The 3 patients with hyperhomocysteinemia at first control showed HH(e) also at second control without developing new complications. At second xamination
4 other patients (9%), that had at entry normal H(e) values, howed hyperhomocysteinemia. Asignificant positive correlation was found between levels detected at first and second examination, of H(e) (p<0.0001), folate (p<0.0001), vitaminB12 (p<0.001) and HbA1c (p=0.02). Both at first and second examination a significant
negative relationship between H(e) and folate levels (p=0.002 and p<0.0001 respectively) was found. Conclusions: Although in most cases the genetic imprinting seems to influence H(e) and vitamin levels, in some cases hyperhomocysteinemia may appear over
time. While a strict relationship between H(e) and folate was present all the times, the relationship between hyperhomocysteinemia and vascular complications in our
patients was uncertai
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