152 research outputs found
Design and engineering of human TRAIL variants
No full textTRAIL is een humaan eiwit dat bepaalde typen kankercellen aanzet tot geprogrammeerde celdood (apoptose) terwijl het normale cellen met rust laat. Hierdoor is TRAIL een veelbelovend potentieel anti kanker geneesmiddel. Promovendus Almer van der Sloot optimaliseerde TRAIL voor gebruik als geneesmiddel door het enerzijds stabieler te maken en anderzijds selectiever en actiever voor bepaalde typen kankercellen. Ook in combinatie met radiotherapie en bepaalde vormen van chemotherapie lijken de selectieve TRAIL varianten een meer potente anti kanker werking te hebben dan de oorspronkelijke. Hiervoor waren slechts een klein aantal veranderingen nodig in het TRAIL molecuul.
Parallel performance evaluation through critical path analysis
No full textParallel Performance Evaluation through Critical Path Analysis Overeinder, B.J.; Sloot, P.M.A. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract. In this paper we discuss the concept of space-time diagrams as a representation of the execution of an application, and then give a method, based on critical path analysis, for calculating nontrivial upper bounds on the potential parallelism, known as the average parallelism, a complement to the speedup and efficiency
"Equation missing" : A Cross-Platform Programming Framework for Quantum-Accelerated Scientific Computing
No full textThis paper introduces a new cross-platform programming framework for developing quantum-accelerated scientific computing applications and executing them on most of today’s cloud-based quantum computers and simulators. It makes use of C++ template meta-programming techniques to implement quantum algorithms as generic, platform-independent expressions, which get automatically synthesized into device-specific compute kernels upon execution. Our software framework supports concurrent and asynchronous execution of multiple quantum kernels via a CUDA-inspired stream concept.Accepted Author ManuscriptNumerical Analysi
DASEC, een systeem voor oproepgestuurd goederenvervoer.
No full textDit rapport beschrijft de programmatuur die nodig is voor het toewijzen van aanvragen voor vervoer in een oproepgestuurd goederenvervoersysteem. Tevens wordt ingegaan op de mtheode om een vervoersnetwerkbeschrijving op te stellen. De resultaten van een aantal simulaties met de ontwikkelde programmatuur worden toegelicht.Electrical Engineering, Mathematics and Computer ScienceVakgroep Automatische Verkeerssysteme
Structural adaptation of tumor vascular networks
No full textTumor vascular networks play an important role in various treatments of cancer. Tumor vascular morphology and hemodynamics are known to be different from normal healthy vascular networks. For improvement of treatment, the origins of these differences need to be understood. Differences in morphology and hemodynamics might be due to changes in structural diameter adaptation process. To address this question, a healthy and a tumor vascular network were visualized by intravital microscopy and were reconstructed. They were used as input to a mathematical model that simulated structural diameter adaptation, which had been developed and validated previously for healthy tissues. The tumor vascular network was used as input to the model and simulations were executed with adaptation rules at control values, as determined for healthy vascular networks. The healthy vascular network was used as input to the model and simulations were carried out with adaptation rules deliberately changed to mimic tumor situations. Network characteristics, distributions of pressure, flow and oxygen pressure and vascular network morphology were used to quantify the impact of simulations with control, respectively tumor adaptation rules. It could be seen that the tumor vascular network adapted its diameters so that it adjusted its characteristics to healthy vascular network values. Conversely, the healthy vascular network had adapted its diameters after simulation with tumor adaptation rules, so that it adopted tumor vascular network characteristics. These results show that tumor adaptation rules are different from healthy adaptation rules and can be identified by simulating structural diameter adaptation with changed adaptation rules.Biomechanical EngineeringMechanical, Maritime and Materials Engineerin
Modelling traffic in the Randstad using a dynamic zone model based on the Network Fundamental Diagram
No full textThe aim of this master thesis is to develop a dynamic zone-based traffic model for large areas, using the concept of the Network Fundamental Diagram (NFD), which relates the average internal flow (production) and speed in a zone to the number of vehicles in the same zone (accumulation). The model that has been developed is then applied to the Randstad area, and it is analyzed whether the model is able to reproduce the observed congestion patterns and travel times between the zones.Civil Engineering | Transport and Plannin
Analyse en metingen van co-channel interferentie en handover in een macro - cellulaire bebouwde omgeving
No full textIn samenwerking met KPN Research zijn metingen uitgevoerd ter bepaling van de co-channel interferentie in een macro - cellulaire bebouwde omgeving. De metingen zijn verricht in de regio’s Den Haag, Rijswijk en Wateringen. De co-channel interferentie is hierbij beperkt tot een wisselwerking tussen twee cellen. Met behulp van deze metingen is de co-channel interferentie in een bebouwde omgeving onderzocht. Vervolgens is een dynamische situatie gesimuleerd van een rijdend mobiel waarbij de initiatie van de handover is geanalyseerd.Applied SciencesElectrotechniekTelecommunications and Traffic Control Systems Grou
Disputationum ethicarum secunda de virtutibus in specie, nominatim temperantia, ex 10. 11. 12. capp. 3. Eth.
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