20 research outputs found
Daniel Seichepine, Assistant Professor, Neuropsychology (UNHM) travel to Brazil
No full textProfessor Seichepine lectured on the neuropsychology of neurodegenerative disorders and dementia, such as Alzheimer’s disease and chronic traumatic encephalopathy, at the Universidade Estadual do Centro-Oeste (Midwestern State University)
Vision, perception, visuospatial cognition and everyday function in subtypes of Parkinson's disease
No full textThesis (Ph.D.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.Parkinson's disease (PD) has traditionally been viewed as a movement disorder characterized by tremor, rigidity, akinesia, and impaired posture and gait, but more recent work documents a range of concomitant non-motor symptoms including changes in sensation, perception, and visuospatial cognition. PD subtypes are defined by characteristics of motor symptoms at disease onset, such as type of symptom (tremor, non-tremor) and body side of symptom onset, but the nature of the non-motor symptoms accompanying these subtypes is relatively unknown. The first two studies explored visual perceptual and spatial function in relation to PD subtypes. PD patients with non-tremor symptoms at onset were hypothesized to perform more poorly than those with tremor onset because of greater cortical and subcortical neuropathology. Patients with symptoms starting on the left side of the body were hypothesized to perform more poorly than right-onset patients on visuospatial functioning, reflecting hemispheric asymmetries in dopamine levels. The third study examined an intervention to counteract visual deficits relevant to activities of daily living (ADLs) in PD in general.
Study 1 used a self-report measure to identify which visual domains are most
affected in PD subtypes, as well as objective measures of visual functioning. Patients
with non-tremor onset, but not those with tremor onset, had impairments in contrast
sensitivity and specific visual ADLs. Study 2 used a standard neuropsychological
measure to assess visuospatial functioning in PD subtypes. Patients with left-side motor
symptoms at onset and non-tremor symptoms at onset performed significantly more
poorly than the control group. Study 3 examined the effect of visually-based
environmental enhancements on five instrumental ADLs in PD and control participants.
These enhancements improved performance on specific ADLs in both groups.
The present studies provided evidence for reduced contrast sensitivity, worse
visuospatial functioning, and more self-reported problems with visual ADLs in the nontremor
PD subtype than in those with tremor at onset, and worse visuospatial functioning
in patients with left than right motor symptoms at onset. Characterizing perceptual and
cognitive changes in PD subtypes provides a more complete picture of the disorder.
Future studies should focus on the relation between these changes and ADLs in PD
subtypes.2999-01-0
Lifetime Multiple Mild Traumatic Brain Injuries are Associated with Cognitive and Mood Symptoms in Young Healthy College Students
No full textBackground/Objectives: Repetitive mild traumatic brain injury (mTBI; also known as concussion) has been associated with a range of long-term mood and cognitive deficits, including executive dysfunction. Previous research in athletes suggests that cognitive and mood problems are associated with a history of repetitive mTBI. However, to date no studies have examined the impact of a lifetime accumulation of repetitive mTBIs on cognition, particularly executive functioning, and mood in a sample of young adults who were not athletes. Therefore, the present study looked at potential effects of repetitive mTBIs on self-reported cognitive complaints, executive functioning and mood in young adults.Methods: Eighty-four total students responded, and twenty-six of those were excluded from analyses due to reporting only 1 mTBI. The final sample consisted of 58 healthy young adults (mean age = 22.84, STD = 4.88) who completed the Cognitive Complaint Index (CCI) the Behavior Rating Inventory of Executive Function, adult version (BRIEF-A) and the Beck Depression Inventory, second edition (BDI-II). Twenty-nine participants denied having an mTBI history and 29 reported two or more lifetime mTBIs (range 2-7). Twenty-six participants reported a lifetime history of one mTBI and therefore were excluded from analysis given this study was focused on potential effects of repetitive injuries on cognition and mood. Results: Young otherwise healthy adults with a lifetime history of repetitive mTBI compared to those that reported no history of mTBI reported more change in cognitive functioning over the past five years, worse executive functioning and more symptoms of depression. As the number of lifetime mTBIs increased scores on the CCI, BRIEF-A, and BDI-II also increased, indicating worse functioning. Conclusion: These findings suggest that a lifetime accumulation of two or more mTBIs as compared to a history of no reported mTBIs may result in worse cognitive functioning and symptoms of depression in young adults.Key words: mild traumatic brain injury, neuropsychology, executive function, cognition Word Count: 2,40
P3–237: Office‐based assessment of driving safety in older drivers with and without dementia
No full textReliability of the Balance Error Scoring System test is maintained during remote administration
No full textAim: This study investigates if scores on the Balance Error Scoring System (BESS) are affected when administered remotely. Materials & methods: Participants included 26 undergraduate students, aged 19-32 (mean: 21.85 ± 2.95). Each participant received the BESS test remotely and in person, and scores on each were compared. To minimize potential practice effects, participants were randomly assigned to two equal sized groups to take the BESS remotely first or in person first. Results: The mean difference between scores for the remote and in-person assessments was 0.711 (95% CI: 0.708–2.131). There was no significant difference between scores (p = 0.312) indicating the BESS maintains reliability when administered remotely. Conclusion: Administration of the BESS remotely was possible without any significant challenges
Reliability of the Balance Error Scoring System test is maintained during remote administration
No full textAim: This study investigates if scores on the Balance Error Scoring System (BESS) are affected when administered remotely. Materials & methods: Participants included 26 undergraduate students, aged 19-32 (mean: 21.85 ± 2.95). Each participant received the BESS test remotely and in person, and scores on each were compared. To minimize potential practice effects, participants were randomly assigned to two equal sized groups to take the BESS remotely first or in person first. Results: The mean difference between scores for the remote and in-person assessments was 0.711 (95% CI: 0.708–2.131). There was no significant difference between scores (p = 0.312) indicating the BESS maintains reliability when administered remotely. Conclusion: Administration of the BESS remotely was possible without any significant challenges
Improvement of thermally sprayed abradable coating by microstructure control
No full textInternational audienc
Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson’s Disease
No full textBackground/Objectives: Visuospatial problems are common in Parkinson\u27s disease (PD) and likely stem from dysfunction in dopaminergic pathways and consequent disruption of cortical functioning. Characterizing the motor symptoms at disease onset provides a method of observing how dysfunction in these pathways influences visuospatial cognition. We examined two types of motor characteristics: Body side (left or right) and type of initial symptom (tremor or symptom other than tremor).
Methods: 31 non-demented patients with PD, 16 with left-side onset (LPD) and 15 with right-side onset (RPD), as well as 17 healthy control participants (HC). The PD group was also divided by type of initial motor symptom, 15 having tremor as the initial symptom and 16 having an initial symptom other than tremor. Visuospatial function was assessed with the Clock Drawing Test.
Results: Of the four Clock Drawing scoring methods used, the Rouleau method showed sensitivity to subgroup differences. As predicted, the LPD and non-tremor subgroups, but not the other subgroups, performed more poorly than the HC group.
Conclusion: The findings provide further evidence for differences in cognition between these subtypes of PD and highlight the importance of considering disease subtypes when examining cognition
