1,101 research outputs found
macarthur-lab/seqr: seqr
No full text<ul>
<li>simplified install using Kubernetes / Docker: <a href="https://github.com/macarthur-lab/seqr/blob/master/deploy/kubernetes/README.md">https://github.com/macarthur-lab/seqr/blob/master/deploy/kubernetes/README.md</a></li>
<li>new React.js-based UI for the landing page, project page, and case review page: <a href="https://github.com/macarthur-lab/seqr/tree/master/ui">https://github.com/macarthur-lab/seqr/tree/master/ui</a> </li>
<li>updated APIs (<a href="https://github.com/macarthur-lab/seqr/tree/master/seqr">https://github.com/macarthur-lab/seqr/tree/master/seqr</a>) and database schema (<a href="https://github.com/macarthur-lab/seqr/blob/master/seqr/models.py">https://github.com/macarthur-lab/seqr/blob/master/seqr/models.py</a>)</li>
</ul>
Alien Registration- Macarthur, Daniel (Sidney, Kennebec County)
No full texthttps://digitalmaine.com/alien_docs/16385/thumbnail.jp
Mathematical modelling of malignant growth and invasion
No full textThe work presented in this thesis is concerned with the growth and development of malignancy. Such development can be thought of in terms of cell proliferation and associated morphological developments as well as in terms of active migration of malignant cells. Consequently this thesis can broadly be divided into two parts, one concerning growth dynamics in tumours, and the other active invasion of tissue by the malignancy. The first part of this thesis is concerned with the development of growth induced stresses within a multi-cell tumour spheroid (MCS), and associated structural changes. In particular, the growth and development of necrotic regions within a MCS is studied. Traditionally necrotic regions are considered to arise from the accumulation of necrotic cell debris, and assuch form under chemically adverse conditions e.g. in hypoxic or nutrient deficient regions. However, it has been observed that the connection between such conditions and necrosis formation is not so simple. In particular, necrosis formation can precede or follow hypoxia. Therefore, in this thesis we examine a novel mechanism for necrosis formation, by allowing necrotic regions to arise under conditions of adverse mechanical stress. We consequently develop a model for spheroid growth in which necrosis forms in areas of mechanical tension but does not assume this formation a priori, and show that under the right conditions such a spheroid will support necrosis formation pre-hypoxia. Models in which the MCS is composed of a viscous, an elastic, and a viscoelastic material are all considered, and it is concluded that both biologically and mathematically a tumour spheroid is best modelled as a viscoelastic medium. The second part of this thesis is concerned with active migration of cells across a substratevia haptotaxis, and the application of this motility mechanism to glioma invasion of the central nervous system. A novel model for receptor mediated haptotaxis is developed which allows adhesion, proteolysis of extra-cellular matrix (ECM) components and subsequent migration of a cell to be modelled in a biochemically accurate manner. This single cell framework is then used to derive an average cell continuum velocity and flux, and these in turn are used to examine cell population migration via receptor mediated haptotaxis. Under appropriate limits the model presented is shown to reduce to a well known class of models, and as such provides a sound biochemical basis for these previous modelling attempts. Invasion of glioma cells into the central nervous system is studied with particular attention being paid to the effects of glioma-host interactions in modulation of migration velocity and interface shape. It is concluded that, under certain circumstances, an up-regulation ofpro-migratory ECM components by the brain can inhibit glioma migration by slowing cell migration speed, and by sharpening the glioma-host interface. The phenomena of interface sharpening is seen as important, since gliomas often show diffuse boarders which present problems for their surgical resection within reasonable limits. The model outlined therefore suggests potential avenues for pre-surgical treatment which may prove very fruitful
Engram triptych
No full textChoreography: Bronwen MacArthur
Performers: Taina Bey, Brit Claiborne, Nicole DeWolfe, Barbie Diewald, Sofia Engelman, Nadia Milad Issa, Aubrey Johnson, Bronwen MacArthur, Alison Marsh, Ali Naranjo, Anna Render, Whitney Wilson, Delphine Zhu.
Music: Exploration of the house by Alvin Lucier
Lighting design: Daniel D. Rist
Costume design: Emily Justice Dunn
Video design: Bronwen MacArthur, David Wiggall
Video engineer: David Wiggall
Paintings: Elizabeth Meyersohn
Note: This thesis is a video of choreography and performance. It is part of the MFA Thesis Dance Concert Hue: a continuum
MacArthur in Korea
No full textThere is perhaps a no more controversial or flamboyant twentieth-century American military leader than General of the Army Douglas MacArthur. To those who have knowledge of him and have an opinion, he is either highly revered or much detested. This paper will present various portrayals of Douglas MacArthur during the Korean War. Also presented will be previous evaluations of these works as well as background of the authors, where possible. Some will cast MacArthur in a good light as a skillful general and great leader who better saw the bigger picture of the meaning of the Korean War, while others will seem to go out of their way to smear his reputation and belittle his accomplishments. The ultimate goal of this paper is a criticalreview and evaluation of these works resulting in the author's conclusion as to which is the most accurate work on the command of MacArthur in Korea
Daniel-Joseph MacArthur-Seal: Smuggling and the Remaking of the Eastern Mediterranean
No full textSmuggling and the Remaking of the Eastern Mediterranean, 1912-1940 Daniel-Joseph MacArthur-Seal My current research project demonstrates how the fight against smugglers and its telling became both a motif and a method for the remaking of the eastern Mediterranean as an arc of coherent nation-states within an ordered international system. Over the first half of the twentieth century, smuggling persisted in shaping significant economic and human networks, even while it was transformed by new p..
Reconfiguring Gender, Sexuality, Music, and Higher Education
No full textAn abundance of research in music focused on composers who identify as women and/or lesbians has emerged since the 1980s, but the impacts of undertaking this work as a researcher has not been examined. The chapter thus asks whether working as a feminist and/or queer researcher has negative impacts, noting that in the 1990s Susan McClary claimed that undertaking such work would be tantamount to committing professional suicide. In her recently published work—which is corroborated by her own reflection piece for the present chapter—McClary goes further to reveal that she has also had to contend with violence, including rape and death threats. Is this a common story for researchers in this field? While the chapter’s intention is not to present a definitive answer, it nevertheless suggests that women like McClary who hold tenured academic music positions, and who are clever and outspoken, pose a threat to the musicological establishment and must be silenced. Five female academics—Susan McClary, Elizabeth Wood, Judith Lochhead, Jennifer Shaw, and Gillian Rodger—chosen because they represent two countries (the US and Australia), thereby giving a glimpse into a geographical exchange, as well as generational and work status differences, were asked to write short reflection pieces about their experiences. How do they negotiate a field that is/has been hostile? Is it easier to work in feminist and queer musicology in the present day than it was in the 1990s? Drawing on new materialist philosophy, especially that of physicist, Karen Barad, the author (Macarthur) carries out a series of diffractive readings of the contributors’ reflections. In a Baradian sense, diffraction is to do with the behaviour of light and sound waves, the idea that when waves overlap or encounter obstructions, they form patterns of difference. If we transpose this idea to feminist and queer musicology, patterns of difference emerge that counter the usual positive versus negative binary constructions.Sally Macarthur, with Susan McClary, Elizabeth Wood, Judith Lochhead, Jennifer Shaw, and Gillian Rodge
Book Review: American Caesar: Douglas MacArthur 1880-1964
No full textBook Title: American Caesar: Douglas MacArthur 1880-1964Book Author: William ManchesterLittle, Brown, 1978. 793pp
Virtual influence: leveraging social media as a leadership tool.
No full textA MacArthur writing contest winning author examines concepts and objectives of leadership and the phenomenon of social media
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