65 research outputs found
Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V).
No full textThe Fifth Eilat Conference on New Antiepileptic Drugs (AEDs) took place at the Dan Hotel, Eilat, Israel, 25-29 June 2000. Basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included recognition of unexpected adverse effects, new indications of AEDs, and patient-tailored AED therapy. According to tradition, the central part of the conference was devoted to a review of AEDs in development, as well to updates on AEDs that have been marketed in recent years. This article summarizes the information presented on drugs in preclinical and clinical development, including AWD 131-138, DP-valproate, harkoseride, LY300164, NPS 1776, NW 1015, pregabalin, remacemide, retigabine, rufinamide and valrocemide. The potential value of an innovative strategy, porcine embryonic GABAergic cell transplants, is also discussed. Finally, updates on felbamate, fosphenytoin, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, vigabatrin, zonisamide, and the antiepileptic vagal stimulator device are presented
How Fast Does the Steppe Eagle Population Decline? Survey Results from Eilat, Israel
No full textThe world Steppe Eagle (Aquila nipalensis) population is considered Endangered and is rapidly declining across most of it range. Eilat, in southernIsrael, is a bottleneck for this species on its migration route fromAfrica in spring. We conducted a series of surveys, counting the passing Steppe Eagles in springs 2015 to 2018 and collecting data about the age of the passing birds. We then compared our data with the Steppe Eagle data collected during four springs between 1977 and 1988. We did not find a significant decline in Steppe Eagle numbers passing Eilat on their spring migration between the two data sets. This implies that the overwintering sites in Africa and the migration flyway to and fromAfrica are relatively safe for the Steppe Eagles. We furthermore found that 75% of the eagles passing are adults and that their main passage is during the third week of February. This information helps to adjust conservation efforts
Trail log - 1990-1994
No full textRolston accounts: South Africa, October 1990. Hawaii Volcanoes National Park. Brazil and United Nations Conference on Environment and Development (UNCED), Rio de Janeiro. Pantanal. Amazon, 1992. Europe, Wales,, Scotland, World Congress of Philosophy, Moscow, 1993, Oxford, England, and Norway, with Arne Naess.Israel and Society for Preservation of Nature in Israel, Eilat, 1994. Finland and North Cape. Bob Marshall Wilderness trip, 1994
L Chain Allelic Inclusion Does Not Increase Autoreactivity in Lupus-Prone New Zealand Black/New Zealand White Mice
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Environmental gradients in the north Red Sea water column.
No full text<p>The environmental parameters (a) temperature, (b) Chl <i>a</i>, (c) total organic nitrogen and (d) logarithm of PAR in the Gulf of Eilat. Parameters are plotted along a 140 m depth gradient, during March (red), May (green), August (blue) and November (brown). Dotted line highlights 60 m depth.</p
Physiological and Biogeochemical Responses of Super-Corals to Thermal Stress from the Northern Gulf of Aqaba, Red Sea
No full textMass coral bleaching is increasing in frequency and severity, leading to the loss of coral abundance and diversity. However, some corals are less susceptible to bleaching than others and can provide a model for identifying the physiological and biogeochemical traits that underlie coral resilience to thermal stress. Corals from Eilat in the Gulf of Aqaba in the northern Red Sea do not bleach unless seawater temperatures are sustained at +6°C or higher above their average summer maximum. This extreme thermal tolerance qualifies these as super-corals, as most corals bleach when exposed to temperatures that are only +1–2°C above their thermal maximum. Here, we conducted a controlled bleaching experiment (+6°C) for 37 days (equivalent to 32° heating weeks) on three species of corals from Eilat: Stylophora pistillata, Pocillopora damicornis, and Favia favus. To assess the response of the holobiont to thermal stress, the following variables were measured on each coral: endosymbiotic algal cell density, Chlorophyll a, endosymbiotic mitotic cell division, total lipids, protein, carbohydrate, and the stable carbon (δ13C) and oxygen (δ18O) isotopic composition of the skeleton and the δ13C of the animal host tissue and endosymbiotic algae. While all three species appeared visibly bleached, their physiological and biogeochemical responses were species-specific. S. pistillata catabolized lipids but still maintained total energy reserves and biomass. Increases in both skeletal δ13C and δ18O indicates that calcification declined in this species. P. damicornis was the least affected by bleaching. It maintained its total energy reserves and biomass, and isotopic evidence suggests that it maintained calcification and was not dependent on heterotrophy for meeting metabolic demand when bleached. Finally, F. favus catabolized protein and carbohydrates, and suffered losses in total energy reserves and biomass. Nevertheless, isotopic evidence suggest that photosynthesis and calcification were maintained, and that this species has a high baseline heterotrophic capacity. Thus, just like their non-super-coral conspecific counterparts, maintaining energy reserves and biomass, and heterotrophic capacity appear to be traits that underlie the thermal tolerance of these super-corals from Eilat. Given the high thermal tolerance of these super-corals, these populations could provide viable seed stock for repopulating coral losses on other reefs
An autoimmune disease prevented by anti-retroviral drugs
No full textAbstract Background Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1. In mice, the absence of Trex1 causes severe myocarditis. The enzyme is thought to degrade endogenous retroelements, thus linking them to autoimmune disease. However, inhibition of reverse transcription by the inhibitor zidovudine (AZT) did not ameliorate the disease, weakening the link to retroelements. Findings Here, we show that two other FDA-approved drugs that inhibit reverse transcriptase can ameliorate the myocarditis in Trex1-null mouse. Conclusions The result suggests that retroelements contribute to this hereditary form of autoimmunity, and that treatment with retroelement inhibitors might ameliorate Aicardi-Goutières syndrome in humans.</p
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