111 research outputs found

    Glypican Is a Modulator of Netrin-Mediated Axon Guidance

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    First author Cassandra Blanchette is a student in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor. We show that developing axons misorient in the absence of LON-2/glypican when the SLT-1/slit guidance pathway is compromised and that LON-2/glypican functions in both the attractive and repulsive UNC-6/netrin pathways. We find that the core LON-2/glypican protein, lacking its heparan sulfate chains, and secreted forms of LON-2/glypican are functional in axon guidance. We also find that LON-2/glypican functions from the epidermal substrate cells to guide axons, and we provide evidence that LON-2/glypican associates with UNC-40/DCC receptor-expressing cells. We propose that LON-2/glypican acts as a modulator of UNC-40/DCC-mediated guidance to fine-tune axonal responses to UNC-6/netrin signals during migration.Neuroscienc

    House Boat = Occupations symbiotiques

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    This catalogue documents a project which called on architects, visual artists and landscape architects to intervene in the urban fabric of the Brewery Creek site, in Hull. Author Blanchette traces the history of the area while Lévesque reflects on the role of the vacant lot and on the many ways it can be invested. Artists and collectives introduce their respective interventions in terms of insertion and occupancy. Texts in French and English. Brief biographical notes

    The presence of exchange : GIFT in artistic research and beyond

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    This publication integrates empirical research, theoretical and fictional texts, art objects and artistic research to a nuanced and diverse understanding of the gift. We have brought together academic scholars and artist-researchers to interrogate existing and projected knowledges about the gift-concept. The Presence of Exchange delves into how artist-researchers conceptualise, materialise, and articulate the idea of gift - its role in society and in our lives. Eleven authors and author groups compile thoughts and ideas expressed in and through artistic practices. They speculate from artistic perspectives on gift economy, gift as an invitation, as a bond in relationships, entanglements and love, gift as a test and especially as a form of presence in exchange.The Presence of Exchange – GIFT in Artistic Research and Beyond --- Relational Painting: A Chain of Encounters and Possibilities / Mirimari Väyrynen -- Shining a Light on the Gâteau Vivant - Structural Colour, Art, Perception, Capital and the Flavobacteria Presentedas a Gift / Laura Beloff & Katri Naukkarinen -- Souvenir of the 'me' / Cynthia Blanchette -- Gift of Inheritance: What is a Gift that One Cannot Experience? / Aurora Del Rio -- Denise Ann Darvall's Heart / Nina Liebenberg -- What Remains: Translating the Absence-Presence of Waste into Video Art / Sonja Lampinen, Olli Pyyhtinen & Niina Uusitalo -- Blankets, Dust and Larch Tree Needles – Reflections on Exchange / Denise Ziegler, Niilo Rinne -- Lahja yhteisöllisen julkisen taiteen maisemassa / Heidi Hänninen / KAS! Kontula Art School -- From the Trees, With Love / Hanna Vahvaselkä -- Weather as a Gift: From Divine Favour to Resonant Dialogues / Juan C. Duarte Regino -- Embrace (of) the Gift / Harri Laakso -- Bios.fi=ei tietoa saavutettavuudesta|sv=okänd tillgänglighet|en=unknown accessibility

    SHORTDIR: Stata module to return the short Windows directory path name

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    shortdir is designed for programmers who want to know what the short directory name (a.k.a. "8.3" name) that DOS names a directory when it contains spaces in the name or has more than 8 characters in the name. This command only works in Windows because it shells out to a DOS prompt in order to get the short directory name that Windows came up with. The formula "Take the first 6 non-space characters and add '~1'" to the directory name does not reliably work in all situations.8.3, directory, short

    IFWINS: Stata module to subset a dataset by 'if exp' before subsetting by 'in range'

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    ifwins is a prefix command that runs most any Stata command that does not modify the dataset in memory (e.g. generate, replace, etc.). ifwins will have 'if' subset the dataset before 'in' subsets the dataset. This is the opposite of what happens when both 'if' and 'in' are used in the same Stata command. If you want to run a Stata command on a certain number of observations when a certain condition exists, use ifwins as a prefix to the desired Stata commanddata management, qualifiers, if, in

    Reply to Cook, Rossberg and Wehmeier

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    All contributions included in the present issue were originally presented at an ‘Author Meets Critics’ session organised by Richard Zach at the Pacific Meeting of the American Philosophical Association in San Diego in the Spring of 2014

    ADOEDIT: Stata module to edit ado file in Stata's do-file editor

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    adoedit attempts to edit whichever ado file named cmdname.ado is first on the current adopath. If none exists, which cmdname is invoked. One cannot edit files larger than 32,000 bytes in the do-file editor, nor can one edit built-in commands. This routine is designed for use by those who are writing their own ado-files, and should be used with caution on components of official Stata.ado-file, edit

    SASWRAPPER: Stata module to run a SAS program from within Stata

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    saswrapper runs a SAS program in batch and prints the output in the Stata results window/log file. This usually occurs by specifying a SAS program file after using, but saswrapper can also run SAS code specified by the pre_sas_prog() and/or post_sas_prog() options. By default, saswrapper will save the current data in memory using savasas and make it available in SAS's WORK library. If that is not desired, use the nodata option. The usesas option tells saswrapper to load the last SAS dataset created in the WORK library by the submitted SAS program into Stata using the SAVASTATA SAS macro.SAS, Stata

    SAVAS: c-shell script for *nix which makes Stata versions of SAS data files

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    The savas c-shell script requires the Stata program savasas (and all its component programs) and the SAS macro savastata which are downloadable below. savas requires some editing to setup for your Unix/Linux box and should be renamed from "savas.csh" to "savas" with no file extension. Installation of this module will go quicker and easier from within Stata by typing "ssc install savasas" and "net get usesas" which also downloads the SAS macro savastata and then downloading savas.csh and the man file savas.1 separately.SAS, data, Stata, transfer, convert, copy,

    SAVASAS: Stata module to save your dataset as a SAS dataset

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    savasas saves the Stata dataset in memory as a SAS file. By default the output dataset will have the same name and be in the same directory, but with the .sas7bdat file name extension and contain all observations and every variable in the Stata data file. Savasas can save to other versions of SAS. Version 8: *.sas7bdat, Version 6: *.ssd01/ *.sd2, SAS 6 Transport/xport: .xpt. Savasas calls SAS to run the SAS program. This requires the ability to run SAS on your computer. If you do not have a working copy of SAS, use the sascode option and copy the SAS program (mySASfile_infile.sas) and the xport data file (mySASfile_infile.raw) to a computer that has a working copy of SAS. The SAS program will need to be modified to point to the location of the xport data file. Savasas works on Windows, Unix, and Linux operating systems.SAS, save, convert, transfer
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