1,721,144 research outputs found
In vivo imaging of oligonucleotides with nuclear tomography
No full textPositron emission tomography (PET) and single photon emission tomography (SPECT) are high-resolution, sensitive, molecular and functional imaging techniques that permit repeated, noninvasive assessment and quantification of specific biological and pharmacological processes in humans. PET and SPECT are also the most advanced technologies currently available for studying in vivo molecular interactions and therefore can advantageously play a key role in both drug discovery and development of pharmaceuticals, by assessing their in vivo distribution, pharmacokinetics, and dynamics, once labeled with a positron or γ-emitter. Recent advances in positron and γ -emitter labeling of bioconjugates allow the design and development of complex high-molecular-weight bioactive chemical structures as radiopharmaceuticals including single-stranded oligonucleotides. Besides, the introduction of high-resolution tomographic devices for imaging the distribution of radioactivity in small animal models such as mice and rats offers a unique opportunity to study the biological behavior of labeled compounds in integrated, unperturbed living systems. The present review illustrates the current technologies for labeling oligonucleotides with various radioisotopes, and their use as in vivo probes of oligonucleotide distribution and molecular interactions in target tissues. Emphasis will be also given to the role which could be played by these technologies in the development of oligonucleotide-based drugs. © 2004 Bentham Science Publishers Ltd
Promoting nuclear medicine in developing countries trough IAEA coordintated research projecs: technical report series 458 and 459
No full textPromoting nuclear medicine in developing countries trough IAEA coordintated research projec
Molecular imaging with endogenous and exogenous ligands: the instance of antibodies, peptides, iodide and cupric ions
No full textNo abstract availabl
On the interpretation of the Namiki–Pascazio order parameter ϵij
No full textThe Namiki-Pascazio theory is employed to formulate an alternative description of wave-function collapse for a single measurement based on a novel interpretation of the role of time in quantum phenomena. The argument makes use of the time-energy uncertainty principle to define the decoherence factor ∈ij as a time-ordering parameter. © 2001 Elsevier Science B.V
Strengthening radiopharmacy practice in IAEA member states
No full textRadiopharmaceuticals are essential components of nuclear medicine procedures. Without radiopharmaceuticals nuclear medicine procedures cannot be performed. Therefore it could be said that 'No radiopharmaceutical-no nuclear medicine.' A good radiopharmacy practice supports nuclear medicine activities by producing radiopharmaceuticals that are safe and are of the required quality in a consistent way. As with any medicinal product, radiopharmaceuticals are required to be produced under carefully controlled conditions and are tested for their quality, prior to the administration to patients, using validated standard operating procedures. These procedures are based on the principles of Good Manufacturing Practice (GMP). The GMP principles are based on scientific knowledge and applicable regulatory requirements and guidance related to radiopharmaceutical productions and use. The International Atomic Energy Agency (IAEA) is committed to promote, in the Member States (MS), a rational and practical approach for the implementation of GMP for compounding or manufacturing of diagnostic or therapeutic radiopharmaceuticals. To pursue this goal the IAEA has developed various mechanisms and collaborations with individual experts in the field and with relevant national and international institutions or organizations. IAEA's activities in promoting radiopharmaceutical science include commissioning expert advice in the form of publications on radiopharmaceutical production, quality control and usage, producing technical guidance on production and regulatory aspects related to new radiopharmaceuticals, creating guidance documentation for self or internal audits of radiopharmaceutical production facilities, producing guidance on implementation of Quality Management System and GMP in radiopharmacy, assisting in creation of specific radiopharmaceutical monographs for the International Pharmacopoeia, and developing radiopharmacy-related human resource capabilities in MS through individual and regional training courses and education programs. IAEA strongly supports development of clinical nuclear medicine services by assisting MS in setting up reliable Radiopharmaceutical production facilities for single photon emission computed tomography, positron emission tomography, and for therapeutic applications. © 2013 Elsevier Inc. All rights reserved
Synthesis and characterization of the new neutral myocardial imaging agent [99mTcN(noet)2] (noet = N-ethyl-N-ethoxydithiocarbamato)
No full textThe synthesis, characterization and electrochemical behaviour of neutral [TcN(noet)2] [noet = Et(EtO)N-CS2-], the first technetium(V) nitrido complex currently under preliminary clinical evaluation for myocardial perfusion, are reported
Association of Co(sep)3+ ions with S2O32- ions: Spectrophotometric, circular dichroism and solubility measurements
No full textThe interaction between Co(sep)3+ and S2O2-3 ions has been investigated by various methods. The interpretation of the results in terms of ion association requires the assumption of the formation of ion pairs, triplets and probably higher aggregates as well. The agreement between the association constants, β1 and β2, obtained by spectrophotometry and by solubility is reasonable for β1 (ion pairs) but not for β2 (ion triplets). Only the order of magnitude of β2 is the same in the two methods. Both spectrophotometric and solubility results indicate that SO2-4 associates with Co(sep)3+ approximately to the same extent as S2O2-3, but consistent results for the association constants could not be obtained
Radiofarmaci
No full textdefinizioni, meccanismi d'azione dei radiofarmaci, radiofarmaci per le diagnostica (SPECT-PET), radiofarmaci per la terapia, preparazione di radiofarmaci e controlli di qualità, generatori, preparazione dei radiofarmaci del Tc-99m, radifarmaci : cardiaci, osteoarticolari, sistema nervoso centrale, apparato urinari
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