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Measurement of sensory and pain thresholds in the subcutaneous tissue by means of electrical stimulation
RILIEVI ERGOSPIROMETRICI, DINAMOMETRICI E METABOLICI IN IN PAZIENTI SOFFERENTI DI SINDROME DA FATICA CRONICA
Effects of diflunisal on cutaneous sensory and pain thresholds
The analgesic activity of diflunisal was evaluated through the measurement of
cutaneous sensory and pain thresholds after electrical stimulation. Twelve
healthy volunteers were examined at baseline and five hourly intervals after oral
administration of 500 mg and 1 gm of diflunisal. The results showed that the
sensory threshold was not modified by diflunisal, but that the pain threshold was
significantly increased two and three hours after 500 mg of diflunisal and one,
two, and three hours after 1 gm of diflunisal. At two hours the pain threshold
was significantly higher after 1 gm than after 500 mg of diflunisal. It is
concluded that diflunisal produces an actual increase of the pain threshold in
healthy human subjects and that the amplitude, latency, and duration of its
effect are dose related
Effetti della somministrazione di un'acqua minerale bicarbonato-calcica sul dolore muscolare tardivo
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