1,721,260 research outputs found
President's letter on unproven cellular therapy
No full textThe International Society for CellularTherapy (ISCT;
www.celltherapysociety.org), with a strategy adopted
more than 5 year ago (Gunter KC et al. Cytotherapy
2010), wishes to continue raising awareness about unproven
cellular therapies. All over the world, there is
a legitimate effort to introduce cellular therapies into
the clinic; however, at the same time a large number
of clinics have begun offering cell-based intervention
for a variety of diseases with questionable safety
or efficacy data or an unclear scientific rationale.This
has led to many vulnerable patients subjecting themselves
to unproven cellular therapies with no adequate
regulatory oversight or reliable information about risks
or benefit.
For this reason, ISCT feels the need to provide a
new source of information: an open document that
represents a sharing of knowledge by leaders in the
field
ESF Exploratory Workshop on Mesenchymal Stem Cells. Around Mesenchymal Stem Cells: Dissection And Exploitation Of Secretory Activity Of MSC For Regenerative Medicine And Anticancer Therapies; Bologna (Italy)
No full textGoal of the workshop is to establish collaborative research in the emerging field of cell-free therapy based on the paracrine activity of MSC. Participants will present state of the art of and new insights on specific fields. Workshop will define: 1) potential clinical application of cell-free therapies, 2) major advantages/limitations 3) gaps in current knowledge. Future activities include: 1) Identification of research issues for clinical translation, 2) Strategy development for joint collaborative research, 3) Education/research training networks, and 4) Preparation of a consensus paper as a preliminary step for grant application
Bimodal Action of MSC in Regenerative Medicine
No full textWorldwide investigations on mesenchymal stromal/stem cells (MSC) have highlighted their regenerative potentials. Subsequent ex vivo & in vivo studies, with or without biomaterial combination, have explored MSC efficiency to repair damaged tissues and organs. This book investigates some of key factors on MSC biology & performance, such as the cell transportation procedures and the vasculogenesis after transplantation. One of the prerequisites for MSC introduction into clinic is their manipulation under good manufacturing practice (GMP) facilities that are often far from the operating theatre. Appropriate cell shipment conditions are poorly defined, therefore in this book we describe the impact of transportation on functional outcome focusing on bone regeneration. We then focused on an innovative approach of adipose tissue regeneration that reduced necrosis and significantly increased vasculogenesis compared with common surgical procedure for adipose tissue reconstruction based on autologous fat transfer. These data may be useful for anyone who studies MSC looking for their introduction into regenerative medicine approaches based on both their differentiation and secretory potential
How do mesenchymal stromal cells exert their therapeutic benefit?
No full textn recent years mesenchymal stromal cells (MSC) have emerged as a major new form of cell therapy. While the original perception was that MSC were stem/progenitor cells with the potential to contribute to the regeneration of tissue, more recent data suggest that the principal mechanism of MSC activity is through the release of soluble mediators that elicit the observed biologic response. Future studies are needed to identify more completely the spectrum of therapeutic applications and delineate better the associated molecular and cellular mechanisms
Optimizing the niche conditions for maximal stem cell engraftment: human and animal model data
No full textWhile animal models are ideal to uncover the biologic basis of pathologic observations and therapeutic interventions, whether such scientific findings, in reality, apply to patients is always an open question. The exceptional human data of Zweegman et al corroborate our murine findings and suggest that the novel mechanisms we describe may, in fact, apply to clinical hematopoietic cell transplantation
1st Annual Meeting of The Forum of Italian Researchers on Mesenchymal and Stromal cells (FIRST); Milano (Italy).
No full textA questo Meeting scientifico, alla sua prima edizione, hanno partecipato i più rappresentativi ricercatori italiani che lavorano sulle cellule staminali mesenchimali da diverse sorgenti tissutali. Inoltre, ricercatori stranieri hanno apportato il loro contributo. L’argomento è stato estremamente innovativo e interessante ed i docenti sono risulatati di assoluto riferimento in materia della ricerca sulle cellule staminali adulte
Enrichment of CD105+ and fibroblast stromal cells from healthy donors and AML patients
No full textFractions isolated with CD105 MicroBeads and Anti-Fibroblast MicroBeads represent sources of bonemarrow stromal cells useful for in vitro investigations of hematological disorders
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