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    Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes

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    In this issue of the British Journal of Nutrition, Breen et al. present a well-written and comprehensive study examining nutrition knowledge among a sample of persons with type 2 diabetes using a validated instrument, food label use and weight satisfaction. The authors explore the relationship between this knowledge and nutrient intake. Although the need of including education on dietary and other lifestyle-related determinants of type 2 diabetes is currently evident and recommended in major guidelines, there is startling scarcity in the literature on this subject

    TERAPIA DELLA SARCOPENIA

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    La sarcopenia e la cachessia sono i disordini muscolari più comune negli adulti. La principale differenza tra le due condizioni è che, a livello istologico, la sarcopenia rappresenta una condizione età correlata che si accompagna a neurodegenerazione, mentre la cachessia è una malattia infiammatoria del muscolo, che è associata a perdita di tessuto adiposo e ad anoressia. E’ stato dimostrato che entrambe le condizioni, nonostante le differenze nella etiologia e fisiopatologia, rispondono positivamente a trattamenti che aumentano la massa e la forza muscolare. Il gold standard attuale della terapia della sarcopenia è l'esercizio fisico. Inoltre, esistono una serie di farmaci che sono disponibili o in fase di sviluppo per il trattamento della sarcopenia. Tra le molecole studiate ricordiamo il megestrolo acetato, gli agonisti della grelina, le molecole selettive dei recettori androgeni, gli antagonisti del recettore della activina, l’espindololo e gli inibitori veloci della troponina muscolare

    CARDIOMETABOLIC SYNDROME AND SARCOPENIC OBESITY IN OLDER PERSONS

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    CARDIOMETABOLIC SYNDROME AND SARCOPENIC OBESITY IN OLDER PERSON

    The relevance of nutrition for the concept of cognitive frailty

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    Purpose of review Physical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. Poor nutrition is a fundamental determinant for both conditions, while various dietary components are proposed to prevent and/or improve them. This updated review discusses the possible influence of nutritional factors on cognitive frailty and its potential mediators. Recent findings: Oxidative stress, low-grade systemic inflammation, neuroinflammation, and altered autophagy, all associated with obesity, metabolic syndrome and insulin resistance, are proposed mechanisms to explain the influence of nutrition on cognitive health. Even if no single food or supplement has definitively demonstrated to affect physical frailty and cognitive impairment, combining various dietary and lifestyle components in the Mediterranean dietary pattern has shown benefit. Summary: Cognitive frailty is a potential useful construct for the early detection of cognitive impairment and physical frailty, in order to implement timely interventions. Validation of this construct is eagerly needed. Nutritional status is a fundamental part of physical frailty, and potentially important in the prevention of cognitive decline. Identifying and treating protein/calorie and individual nutrients insufficiency is mandatory in all older adults. Conversely, overeating in middle age has been associated with cognitive decline in older age. A lifelong balance diet, such as the Mediterranean diet, combined with regular physical and mental exercise, is perhaps the best preventive strategy against cognitive decline in old age
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