1,721,156 research outputs found
Fractional epidermal skin grafting
No full textSkin grafts can be obtained from several sources, both human and animal. Skin grafts can include all or a portion of the skin, including the epidermis and dermis.1 More recently, the use of skin substitutes, dermal fillers and tissue expanders has increased surgeons’ and dermatologists’ ability to cover skin defects resulting from burns, traumatic injury, chronic wounds or excision of cancerous lesions.2 The major sources of skin grafts are autografts, homografts and xenografts. Skin substitutes, dermal fillers and tissue expanders provide additional dermal or epidermal components (or both) for wound coverage and in order to stimulate wound healing
Quantitative evaluation of maceration in venous leg ulcers by transepidermal water loss(TEWL) measurement
No full textSkin maceration is a clinical manifestation in venous leg ulcers that leads to severe consequences for patients' quality of life and wound management. The aim of this study was to explore the use of transepidermal water loss (TEWL) measurement technique to quantify different level of surrounding skin maceration in patients with venous leg ulcers. A total of 50 patients were recruited and TEWL measurements were taken with a portable device on different locations surrounding the leg ulcer and on control skin. A clinical score for maceration was used and correlated to the involvement of surrounding skin. Statistically significant differences of TEWL values were noted between affected skin and control site (P <.001). Statistics showed an increase in TEWL values as the maceration clinical score increased (r = 0.954). Objective monitoring of skin maceration in venous leg ulcer with TEWL measurement represents an useful tool to analyze morphologic changes at different time points during treatment. © 2014 The Author(s)
Efficacy of adalimumab for the treatment of refractory paediatric acrodermatitis continua of hallopeau
Full text linkAcrodermatitis continua of Hallopeau (ACH) is a rare,
chronic disease characterized by acropustular eruptions
predominantly involving the distal phalanges of the hands
and feet with marked involvement of the nail bed. The
sterile pustules may coalesce to form groups of lesions,
which, over time, may spread proximally to involve the
dorsal side of the hands, forearms and feet. Pustulation
of the nail bed and nail matrix are often associated with
onychodystrophy and even anonychia of the involved
digits. Atrophic skin changes, onychodystrophy and
osteolysis are frequently present, causing painful and
disabling lesions
Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult to heal wounds of mixed arterial/venous etiology
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Skin Physiology of the Neonate and Infant: Clinical Implications
No full textSignificance: The skin is a complex and dynamic organ that performs several vital functions. The maturation process of the skin starts at birth with the adaption of the skin to the comparatively dry environment compared to the in utero milieu. This adaptive flexibility results in the unique properties of infant skin. To deliver appropriate care to infant skin, it is necessary to understand that it is evolving with unique characteristics. Recent Advances: The role of biophysical noninvasive techniques in the assessment of skin development underlines the importance of an objective evaluation of skin physiology parameters. Skin hydration, transepidermal water loss, and pH values are measurable with specific instruments that give us an accurate and reproducible assessment during infant skin maturation. The recording of these values, following standard measurement procedures, allows us to evaluate the integrity of the skin barrier and to monitor the functionality of the maturing skin over time. Critical Issues: During the barrier development, impaired skin function makes the skin vulnerable to chemical damage, microbial infections, and skin diseases, possibly compromising the general health of the infant. Preterm newborns, during the first weeks of life, have an even less developed skin barrier and, therefore, are even more at risk. Thus, it is extremely important to evaluate the risk of infection, skin breakdown, topical agent absorption, and the risk of thermoregulation failure. Future Directions: Detailed and objective evaluations of infant skin maturation are necessary to improve infant skin care. The results of these evaluations should be formed into general protocols that will allow doctors and caregivers to give more personalized care to full-term newborns, preterm newborns, and infants
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