1,720,986 research outputs found
The effects of 2% ipobamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma
No full textPURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders.
METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops.
RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes.
CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders
"Effects of a Fixed combination of Timolol and Dorsolamide on ocular hypertension"
No full textRelazione al 3rd International Symposium on Ocular Pharmacology and Pharmaceutics (ISOPP). Lisbon,Portugal,10-13 .2 .2000
In vivo confocal microscopy of conjunctiva-associated lymphoid tissue in healthy humans
No full textPURPOSE: To investigate modifications with aging of the presence, distribution and morphologic features of conjunctiva-associated lymphoid tissue (CALT) in healthy human subjects using laser scanning in vivo confocal microscopy (IVCM).
METHODS:
A total of 108 (age range, 17-75 years) subjects were enrolled. In vivo confocal microscopy of the tarsal and bulbar conjunctiva, and impression cytology (IC) with CD3 (intra-epithelial T-lymphocytes) and CD20 (intra-epithelial B-lymphocytes) antibody immunofluorescence staining were performed. The main outcomes were subepithelial lymphocyte density (LyD), follicular density (FD), and follicular area (FA). The secondary outcomes were follicular reflectivity (FR), and lymphocyte density (FLyD), and CD3 and CD20 positivity.
RESULTS:
Conjunctiva-associated lymphoid tissue was observed in all subjects (97% only superior and 3% in both superior and inferior tarsum). Lymphocyte density ranged from 7.8 to 165.8 cells/mm(2) (46.42 [18.37]; mean [SD]), FD from 0.5 to 19.4 follicles/mm(2) (5.3 [3.6]), and FA from 1110 to 96,280 mm(2) (26,440 [26,280]). All three parameters showed a highly significant inverse cubic relationship with age (P < 0.001); that is, in the first and last parameters a steep decline up to 35 years and above 65 years of age, with a plateau phase between these ages, whereas FA had a gradually decreasing rate of loss over the studied age range. CD3 and CD20 IC were consistent with these results.
CONCLUSIONS:
In vivo confocal microscopy was effective in revealing CALT and modifications these structures undergo with aging. Aging correlated with an involution of all parameters defining lymphoid structures. These modifications may account for the decrease of mucosal immune response and increase of ocular surface diseases in the elderl
Combined phacoemulsification and deep sclerectomy vs phacoemulsification and trabeculectomy.
No full textIrvine-Gass syndrome after cataract surgery resolved by topical therapy with bromfenac eyedrops
No full textA 69-year-old white woman developed cystoid macular edema (CME) 16 days after cataract surgery (Irvine-Gass syndrome). Surgery included phacoemulsification with a small-incision technique, stop-and-chop, and implantation of an intraocular lens in the right eye. No complications occurred during surgery, and the standard treatment of tobramycin 0.3%-dexamethasone 0.1% and diclofenac was started postoperatively. Spectral-domain optical coherence tomography showed a central retinal thickness of 857 μm. Bromfenac 0.9 mg/mL was initiated, and the symptoms improved after 5 days. Approximately a month after the initiation of bromfenac, the CME resolved with a reduction of central retinal thickness to 203 μm. Bromfenac eyedrops have proven to be an effective and noninvasive treatment option in Irvine-Gass syndrome. © ASCRS and ESCRS
Trans-conjunctival aqueous humor outflow in glaucomatous patients treated with prostaglandin analogues: an in vivo confocal microscopy study
No full textPURPOSE: To analyze, using in vivo laser scanning confocal microscopy (LSCM), the conjunctival features in glaucomatous patients receiving prostaglandin analogues (PGA).
METHODS: Eighty eyes of 80 consecutive glaucomatous patients naive for therapy were enrolled; 30 eyes of 30 healthy subjects served as a control. Patients were randomized to: preservative-free (PF) and preserved latanoprost (groups 1 and 2, respectively), PF and preserved timolol (groups 3 and 4), and controls to vehicle of latanoprost or physiological buffered saline solution (groups 5 and 6). All subjects underwent LSCM of bulbar conjunctiva at baseline and 3 months after initiating therapy. The main outcomes were: mean density (MMD: cysts/mm(2)) and mean area (MMA: cysts/mm(2)) of epithelial microcysts. The relations between MMA and MMD with intraocular pressure (IOP), age, and mean defect (MD), were analyzed.
RESULTS: At baseline, microcysts were found in all subjects. At month three, MMD did not change in all groups (p > 0.05). MMA significantly increased only in group 1 from 2,158.81 ± 524.09 to 3,877.77 ± 867.31, and in group 2 from 2,019.71 ± 541.03 to 5,560.39 ± 1,176.14, with values significantly higher in group 2 (p 0.05).
CONCLUSIONS: PGA increased MMA in therapy-naive glaucomatous patients, indicating a possible enhancement of the trans-conjunctival aqueous humor outflow. Therefore, conjunctiva seems an additional target tissue to evaluate the hydrodynamic pathways in glaucoma and modifications induced by medical therapy
Analysis of differences in intraocular pressure evaluation performed with contact and non-contact devices
Full text linkBackground: To evaluate differences of intraocular pressure (IOP) measurements performed with Goldmann applanation tonometer (GAT), dynamic contour tonometer (DCT), rebound tonometry (RT), Ocular Response Analyzer (ORA) and Corvis ST (CST) in eyes screened for refractive surgery. Methods: One eye, only the right one, of 146 patients was included in this study. Each participant was submitted to a corneal analysis with Scheimpflug camera and IOP evaluation with GAT, DCT, RT, ORA and CST. Differences in IOP values obtained thanks to each instruments were compared and then correlations between these discrepancies and morphological features such as mean keratometry (MK) and central corneal thickness (CCT) provided by Pentacam were studied. Software used to run statistical evaluations was SPSS, version 18.0. Results: Study participants had a mean age of 33.1 ± 9.2 years old. IOP values observed in this study were 15.97 ± 2.47 mmHg (GAT), 17.55 ± 2.42 mmHg (DCT), 17.49 ± 2.08 mmHg (RT), 18.51 ± 2.59 mmHg (ORA) and 18.33 ± 2.31 mmHg (CST). The mean CCT was 560.23 ± 31.00 μm, and the mean MK was 43.33 ± 1.35 D. GAT provided significant lower values in comparison to all other devices. DCT and RT gave significantly lower intermediate IOP values than those measured with ORA and CST. All the IOP measures and the differences between devices were significantly correlated with CCT. Conclusions: According to our data, although our findings should be confirmed in further studies, GAT tonometer cannot be used interchangeably with DCT, RT, ORA and CST
Caratteristiche corneali e congiuntivali nell’endoftalmite tardiva post trabeculectomia con mitomicina C: studio in microscopia confocale in vivo
No full textEvaluation of safety at work in psychiatric setting: The “Workplace Safety Assessment”
No full textObjectives: Workplace violence is a common risk for mental health professionals, and psychiatrists often encounter
it in a variety of settings. The aim of this study was to estimate the prevalence and features of violent episodes
toward psychiatrists in various mental healthcare system settings. Methods: All psychiatrists from the Region of
Puglia (Apulia) were contacted (N=285) via email and were administered an on-line standardized questionnaire.
Results: The response rate by psychiatrists was 57%. The main types of violence revealed were “threats” and “verbal
aggression” and, of particular importance, “stalking”. Female psychiatrists seemed to be at a higher risk of becoming
victims of workplace violence, especially as regards verbal abuse (OR: 2.7, 95% CI: 1.2-6.5, c2 6.7, p=0.0095) and
reported more serious psychological consequences with need for rest after the episode of aggression. Conclusions: Our
data confirm that mental health workers, particularly psychiatrists, are healthcare professionals at high risk for workplace
violence. Future implementation of preventive strategies with the aim of reducing aggressive episodes towards
psychiatrists should be a high priority for managers and policy-makers operating in the Italian healthcare sector
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