1,721,038 research outputs found
Emangiopericitoma pelvico. Presentazione di un caso clinico con studio inuminoistochirnico e revisione della letteratura.
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INTERMITTENT ANDROGEN DEPRIVATION IN PATIENTS WITH BIOCHEMICAL FAILURE AFTER RRP FOR CLINICALLY LOCALIZED PROSTATE CANCER
No full textWe report a study in which our objective was to analyze the clinical response during IAD in patients with biochemical failure after RRP for clinically localized prostate cancer. Between February 1994 and May 1996, 34 patients who exhibited a primary postoperative decrease in PSA to below the detection limit after RRP and then showed PSA progression during follow-up were included as group 1 and 17 patients in whom PSA did not decrease after RRP were included as group 2. Patients were offered IAD when PSA progressed over 0.4 ng/ml in group 1 and over 4.0 ng/ml in group 2. Median follow-up is 184 weeks in group 1 and 206 weeks in group 2. The median time "off" therapy increased from 25% (1st cycle) to 68.7% (5th cycle) of the entire cycle in group 1 and from 33.3% to 58.3% in group 2. Nine out of 12 cases with Gleason score greater than or equal to8 failed to respond to IAD and all developed metastatic and/or local failure. No case with Gleason score <7 failed to respond to IAD. Our conclusions suggest that IAD may be effective in patients with biochemical progression after RRP. In our experience, Gleason score seems to be an important variable
EFFECT OF FINASTERIDE ON THE CONCENTRATIONS OF TESTOSTERONE, DIHYDROTESTOSTERONE AND 3A-ANDROSTANEDIOL IN HUMAN BENIGN PROSTATIC HYPERPLASIA TISSUE.
No full textConsiderazioni sull'assetto ormonale gonado-ipofisario nei pazienti subfertili e nei pazienti con disturbi della sessualità.
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Androgen concentrations and their receptors in the periurethral region are higher than those of the subcapsular zone in benign prostatic hyperplasia
No full textTransforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma.
No full textOBJECTIVE:
To analyze the role of the transforming growth factor (TGF)-beta pathway in renal tumors and to verify whether alterations in TGF-beta 1 pathway expression are associated with the grade of tumor differentiation and pathologic stage in renal cell carcinomas.
STUDY DESIGN:
The expression of TGF-beta 1 and TGF-beta receptors (T beta RI and T beta RII), SMAD-2 and SMAD-4 was investigated by immunohistochemistry in normal peritumoral and tumoral tissue from 53 renal cell carcinomas (clear cell type). The gene expression of SMAD-2 and SMAD-4 was also studied by reverse transcription polymerase chain reaction (RT-PCR) in normal peritumoral and tumoral tissue from 6 of 56 primary tumors.
RESULTS:
TGF-beta 1, T beta RI and T beta RII immunoreactivity was more frequent in tumoral than in normal peritumoral renal tissue (96.22%, 79.25% and 75.41% vs. 88.37%, 69.76% and 62.69%), whereas SMAD-2 and SMAD-4 immunoreactivity was more frequent in normal peritumoral than in tumoral tissue (23.25% and 30.23% vs. 15.09% and 7.54%). In tumor areas, immunohistochemical scores were lower for T beta RII than for T beta RI and TGF-beta 1 and higher than SMAD-4 and SMAD-2 scores. TGF-beta 1, T beta RI, T beta RII and SMAD-4 histologic scores correlated with neither the histologic grade of malignancy nor TNM clinical stage, whereas SMAD-2 protein levels were significantly lower in grade 3 than in grade 1 tumors. In the samples of normal kidney and carcinoma studied, RT-PCR detected the correct transcripts for SMAD-2 and SMAD-4, indicating that the RNA of the samples analyzed contained RNA sequences coding for these genes.
CONCLUSION:
Our data support the concept that the reduction of T beta RII and SMAD proteins in renal cell carcinomas is involved in tumor development and suggest an altered TGF-beta/SMAD signaling pathway in kidney neoplasia
Valutazione ultrasonografica dei linfonodi superficiali nel cane
No full textSUMMARY - The ultrasonographic evaluation of 127 superficial lymph nodes was carried out
in 93 dogs with isolated or multiple lymphadenopathy. The lymph nodal shape, ecogenicity,
internal architecture and vascular distribution as well as arterial vascular parameters (i.e., mean
velocity, resistive index and pulsatility index) were evaluated. Three groups of lymph nodes
were identified: leishmania (n = 50), reactive (n = 44) and lymphoma (n= 33). Differences were
found mainly regarding shape, margins, ecotexture and vascular distribution in the three groups
of lymph nodes
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