1,720,985 research outputs found
Valutazione dell’impatto del traforo del Gran Sasso sul sistema acquifero attraverso l’analisi del bilancio idrogeologico della sorgente Rio Arno
No full textElementi minori e rapporti caratteristici delle acque sorgive del Gran Sasso (Italia centrale) per caratterizzare il comportamento idrodinamico degli acquiferi carbonatici
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Chronic pelvic pain: comorbidity between chronic musculoskeletal pain and vulvodynia
No full textChronic pelvic pain (CPP) is a common condition that has a major impact on the quality of life of both men and women. Male CPP is usually attributable to well-defined urogenital conditions (most frequently infectious/non infectious prostatic diseases) or musculoskeletal or bowel diseases, whereas the features of female CPP are much more complex and are of particular clinical and epidemiological importance. It is a multifactorial syndrome that can be due to diseases of the urogenital, gastrointestinal, or musculoskeletal systems, or to neurological or neuropsychiatric disorders. It is not always easy to identify its predominant pathogenesis, although it often occurs as a central sensitization syndrome triggered by an initial stimulus which is no longer detectable and only manifests itself clinically through pain. In this respect, there are some very interesting relationships between vulvodynia and fibromyalgic syndrome, as identified in a preliminary study of women with chronic musculoskeletal pain in which it was demonstrated that vulvar pain plays an important role, although it is often overlooked and undiagnosed
radon come tracciante delle acque sorgive finalizzato alla vulnerabilità degli acquiferi carbonatici complessi: l’esempio del gruppo sorgivo del Rio Arno (Gran Sasso, Italia centrale)
No full textCaratterizzazione del circuito delle acque sotterranee degli acquiferi carsici tramite lo studio del contenuto in radon delle sorgenti del Gran Sasso (Italia centrale)
No full textOxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis
No full textOBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA).
METHODS: Patients with RA (n = 29), suffering from moderate to severe pain for more than 3 months, were included in the study, except those under RA therapy with biological drugs. The treatment started with oxycodone/acetaminophen at the dosage of 5 mg/325 mg, and then the dosage was titrated until the attainment of good pain relief. Antiemetic and laxative therapy was used for the prophylaxis of known opioid-related adverse events.
RESULTS: Patients continued their RA therapy without changing the dosages, reported reduced pain intensity and disease activity, and improvement of disability. Forty-two percent of patients had a good clinical response to oxycodone/acetaminophen treatment, according to European League against Rheumatism (EULAR) assessment criteria, and 50 percent of patients reached the American College of Rheumatology 20 percent improvement criteria (ACR20). At the end of the study, the mean (+/- SD) daily effective oxycodone/acetaminophen dose was 13.8 (+/- 6.8) mg/720.4 (+/- 291.0) mg. No serious adverse event was observed. Nausea, vomiting, and stipsis of mild-moderate intensity were the most common adverse events.
CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable
Caratterizzazione del circuito delle acque sotterranee degli acquiferi carsici tramite lo studio del contenuto in radon delle sorgenti del Gran Sasso (Italia centrale)
No full textIl radon come tracciante delle acque sorgive finalizzato alla vulnerabilità degli acquiferi carbonatici complessi: l’esempio del gruppo sorgivo del Rio Arno (Gran Sasso, Italia centrale)
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