1,720,979 research outputs found
Preparazione di forme solubili di inibitori dell'istone deacetilasi mediante ciclodestrine
No full textsi comunica che l'ateneo ha autorizzato l'estensione del brevetto all'estero con procedura PCT/IT7200800004
Preparation of soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins for use in pharmaceutical compositions
No full textThis invention relates to the prepn. of sol. forms of complexes of histone deacetylase inhibitors, such as I (X = CH, N), with cyclodextrins. The prepn. process involved the formation of inclusion complexes with cyclodextrins with the aid of microwaves. The prepd. complexes were claimed for therapeutic use in the treatment of diseases, such as leishmania, diseases related to aging, mental retardation, neurodegeneration, anxiety, osteoarthritis, psychoses, cancer, type I diabetes, epilepsy and spinal muscular atrophy. [on SciFinder(R)
U.V. and NMR conformational studies on one electron and two electron reduced species from NAD(P)+ -model pyridinium salts.
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Isomerizzazioni di alcune 1,6-diidropiridine alchilsostituite modelli dei coenzimi piridinici naturali
No full textComposizione e stabilità degli olii di semi prodotti per spremitura a freddo ad elevato contenuto di acidi grassi poliinsaturi
No full textGas phase H/D exchange between arenium ions and selected bases. The site of protonation of simple aromatics
No full textH/D exchange between arenium ions bearing various substituents (Y ) Et, Me2CH, CF3, CF3CO,
NO2, Me3Si) on a perdeuterated ring and bases having at least one H atom at the active site are described. A
radiolytic technique operating at atmospheric pressure and allowing the recovery of neutral end products was
used. The exchange depends on features of both the base (structure, proton affinity) and the arenium ion.
The elementary step for back proton transfer from the protonated base to the neutral arene has been studied
by NMR analysis of the H distribution within YC6D4H. The protonation was found to involve the most basic
ring positions: ortho/para for alkyl substituents (Y ) Et, Me2CH) and ortho/meta for electron-withdrawing
substituents (Y ) CF3, CF3CO, NO2)
Riduzione elettrochimica monoelettronica di sali di N-alchil e N-alchilaril-3-cianopiridinio polimetilsostituiti.
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