1,720,983 research outputs found

    Erratum: Sleep dysregulation, memory impairment, and CSF biomarkers during different levels of neurocognitive functioning in Alzheimer's disease course (Alzheimer's Research & Therapy (2020) 12 5 DOI: 10.1186/s13195-019-0571-3)

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    Following publication of the original article [1], the authors reported two errors in the Results section. 1. The sentence “TST was lower in CN, SCI, and MCI compared to mAD patients who in turn showed a lower TST than msAD patients.” under subsection “PSG data (one-way ANOVA analysis)”should be replaced with: TST was HIGHER in CN, SCI, and MCI compared to mAD patients who in turn showed a HIGHER TST than msAD patients. 2. The sentence “Was excluded as it presented split loadings on all factors, and SE and TIB were excluded as they were computed from other polysomnographic parameters.” under subsection “Principal component analysis” should be removed

    XI Seminar - PhD Day COVID-19: Facing a multi(face)phase pandemic Virtual Meeting Organized by the Italian National Institute of Health and Sapienza University of Rome September 17 and 24, October 1 and 8, 2020

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    The 11th Seminar of PhD students in Infectious Diseases, Microbiology and Health Sciences has been delayed and will be carried out online due to the recent COVID-19 pandemic. Indeed, this tragical event, that has dramatically affected people’s life all over the world, will be the core of the topics considered. The Seminar is scheduled in four days, each characterized by an in-depth analysis of topics related to the pandemic, such as the establishment of predictive models, the clinical, diagnostic and anatomopathological aspects, the effects of social distancing and the impact of the pandemic on the socially less-favoured people. Key words: Pandemic; COVID-19; Microbiology, Infectious Diseases, Public Health, Social Medicine, Forensic Medicin

    Italian revised memory and behavior problems checklist (It-RMBPC): validation and psychometric properties in Alzheimer’s disease caregivers

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    Behavioral and psychiatric symptoms (BPSD), common in persons with Alzheimer’s disease (AD), are known to be associated with caregiver burdening. Therefore, early recognition of BPSD is necessary to protect these caregivers. The aim of this validation study was to test the internal consistency, test–retest reliability and concurrent validity of an Italian translation of the revised memory and behavior problems checklist (RMBPC), as it demonstrated high plasticity in timely measuring the day-to-day BPSD changes that challenge caregivers. A cohort of 355 dyads composed of AD subjects and their principal caregivers were assessed with the Italian version of RMPBC capitalizing on the information provided by the latter ones. The results were compared with the ones from other predictors (i.e., the Zarit Burben Interview, the Hospital Anxiety and Depression Scale, the EurQuality of Life, the neuropsychiatric symptoms). The validity and stability of the It-RMBPC resulted being solid and concurrent reliability resulted having higher correlations with principal caregiver anxiety level. Future studies on the role of BPSD in fostering anxiety in AD principal caregivers are merited

    The Service for Monitoring and Early Intervention against psychoLogical and Mental suffering in young people (SMILE) at the University of L'Aquila: first year experience

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    Objective: In the present report, we describe the organization of our multidisciplinary mental health primary care intervention for youths with psychiatric problems and we report preliminary evidence of its effectiveness. Methods: Our service has been named SMILE, the acronym of "Servizio di Monitoraggio e Intervento precoce per le Lotta agli Esordi della sofferenza mentale e psicologica nei giovani". It has been established within the Psychiatric Unit of the University of L'Aquila. Aim of the service is to allow systematic evaluation, recognition and integrated treatment (psychological, psychosocial and psychopharmacological) of early mental and psychological problems in young people, to prevent psychological discomfort and mental illness, to warrant continuity of care in all phases of discomfort and to recognise and offer care for mental disorders at onset. Other missions of our service include early recognition of the pre-psychotic prodromal stage and the psychotic pre-phase, in order to permit the identification of the largest possible proportion of at-risk individuals, as early as possible, and their referral to appropriate treatment. Furthermore, we provide medical psychiatric residents with training to recognise and treat pre-morbid, prodromic and early signs and symptoms of psychiatric problems and mental disorders. Results: One hundred seventy-four patients (80.5%) were admitted more than once, for a total of 685 admissions. Two hundred ninety-eight admissions (61.5%) were for cognitive-behavioural therapy care, one hundred nineteen admissions (25,5%) were for psychosocial integrated treatment care while 77 admissions (15,9%) were only for pharmacological treatment care and active treatment check. We divided in five macroarea diagnostic hypothesis sub-groups the different clinical dimension observed, also considering the non-clinical needs (Psychological discomfort/derangement Macro-area; Anxiety Macro-area; At risk mental state Macro-area; Mood Macro-area; Psychosis Macro-area). The most frequent symptoms detected were anxiety, depression, sleep disorders, eating disorders, trouble with thinking and concentration, reduced drive and motivation, loss of energy, social withdrawal, school and/or work problems, conduct problems/hypo manic behaviour, psychosomatic problems. Conclusions: The SMILE service has been established a comprehensive early intervention service providing most of the mental health service requirements for young people, across a broad range of mental suffering states and overt psychiatric symptoms. Notably, it is a significant advance over what was provided before in Italy. Hopefully, the development of early intervention programs for mental suffering will result in better linkages between child and adult psychiatry services and also with those involved in long-term care to ensure treatment of psychiatric disorders throughout the life cycle

    A systematic review and meta-analysis on the prevalence of dementia in europe. estimates from the highest-quality studies adopting the dsm iv diagnostic criteria

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    BACKGROUND: Dementia, including Alzheimer's disease (AD), is one of the most burdensome medical conditions. Usually, the reviews that aim at calculating the prevalence of dementia include estimates from studies without assessing their methodological quality. Alzheimer's Disease International (ADI) proposed a score to assess the methodological quality of population-based studies aimed at estimating the prevalence of dementia. During the last three years, the European Commission has funded three projects (Eurodem, EuroCoDe, and ALCOVE) in order to estimate the prevalence of dementia in Europe. OBJECTIVE: The aim of this study was to perform a systematic review and meta-analysis of data on the prevalence of dementia in Europe derived from studies that included only subjects with a diagnosis of dementia according to the DSM IV criteria, and that had a high quality score according to ADI criteria. METHODS: We considered the studies selected by the two projects EuroCoDe (1993-2007) and Alcove (2008-2011), and we performed a new bibliographic search. For the systematic review, we only selected the subset of articles that included subjects with a diagnosis of dementia according to the DSM IV criteria. The studies were qualitatively assessed using the ADI tool. RESULTS: The meta-analysis considered 9 studies that were carried out in Europe between 1993 and 2018 including a total of 18,263 participants, of which 2,137 were diagnosed with dementia. The prevalence rate standardized for age and sex resulted 7.1%. DISCUSSION: This is the first systematic review on the prevalence of dementia in Europe considering only high-quality studies adopting the same diagnostic criteria (i.e., DSM IV)

    E-learning Course for Healthcare Professionals: Continuing Education for Idiopathic Scoliosis

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    The objective of this study is to analyze the results of the e-learning course “Health promotion, prevention, diagnosis and treatment of idiopathic scoliosis,” directed to the Italian healthcare professionals involved in idiopathic scoliosis management. The e-learning course, based on the problem-based learning methodology, was directed to health professionals previously enrolled to the University of Rome’s research project “Prevention, diagnosis and treatment of idiopathic scoliosis: evaluation of skills acquired in health professionals through distance learning.” This study is focused on the analysis of the participant’s data. A significant improvement in knowledge (t = 17.2; p < 0.001) was found in participants’ scores from pre- and post-test. 80.1% of participants passed the final certification test. The final satisfaction questionnaire showed a high level of satisfaction among participants. Health professionals involved in idiopathic scoliosis management need adequate training, based on methods appropriate to their professional context. The e-learning course’s results are positive and in line with the project’s task; moreover, this confirms the validity of an active didactic approach such as the problem-based learning
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