1,721,055 research outputs found
Plasma lipid peroxidation and nitric oxide in the elderly: relation to platelet function
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Influence of acute exercise on human platelet responsiveness: possible involvement of exercise-induced oxidative stress.
No full textThe aim of this study was to evaluate in sedentary male subjects the effects of
an acute bout of strenuous and moderate exercise on ex vivo platelet
responsiveness and its possible relationship with exercise-associated
modifications of oxidant-antioxidant status. An increased ADP- and
collagen-evoked platelet aggregation associated with modified membrane fluidity
and ion homeostasis was observed after exhaustive exercise. After moderate
exercise, we found a decrease of platelet aggregation evoked by low
concentrations of agonists. Strenuous exercise, but not moderate exertion,
resulted in the enhanced accumulation of secondary products of lipid
peroxidation, decreased total antioxidant capacity, including a diminished
superoxide dismutase activity, and increased susceptibility of low-density
lipoprotein (LDL) to in vitro oxidation. Acute elevation of plasma
nitrite/nitrate (NOx) content was observed following each single session of
physical test, whilst the platelet NOx content was decreased after strenuous
exercise and increased after moderate exercise. Findings of the present study
suggest that oxidative stress induced by acute strenuous exercise may interfere
with platelet responsiveness most likely by promoting oxidized LDL-mediated
platelet activation and by decreasing plasma and platelet-derived nitric oxide
(NO) bioactivity. Moreover, our results further suggest that platelet
responsiveness following an acute moderate physical stressor may depend on the
efficiency of plasma and intraplatelet NO to desensitize platelets to agonist
stimulation
In vitro short-term response of human erythrocyte to implant materiels used in maxillo-facial rigid fixation.
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