1,721,094 research outputs found
The energetic cost of NNT-dependent ROS removal
Full text linkUnder conditions of high nutrient availability and low ATP synthesis, mitochondria generate reactive oxygen species (ROS) that must be removed to avoid cell injury. Among the enzymes involved in this scavenging process, peroxidases play a crucial role, using NADPH provided mostly by nicotinamide nucleotide transhydrogenase (NNT). However, scarce information is available on how and to what extent ROS formation is linked to mitochondrial oxygen consumption. A new study by Smith et al. shows that NNT activity maintains low ROS levels by means of a fine modulation of mitochondrial oxygen utilization
Cause e conseguenze della estensione dell’area ischemico-necrotica dopo infarto miocardico.
No full textβ2-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure?
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Le alterazioni metaboliche della cellula miocardica ischemica in relazione alle possibilità terapeutiche.
No full textModificazioni metaboliche e contrattili indotte da diversi substrati in corso di ischemia sperimentale e successiva riperfusione.
No full textFunzionalità mitocondriale e omeostasi del calcio in corso di ischemia sperimentale. Effetto protettivo del verapamil.
No full textThe mitochondrial permeability transition pore and cyclophilin D in cardioprotection
No full textMitochondria play a central role in heart energy metabolism and Ca2+ homeostasis and are involved in the pathogenesis of many forms of heart disease. The body of knowledge on mitochondrial pathophysiology in living cells and organs is increasing, and so is the interest in mitochondria as potential targets for cardioprotection. This critical review will focus on the permeability transition pore (PTP) and its regulation by cyclophilin (CyP) D as effectors of endogenous protective mechanisms and as potential drug targets. The complexity of the regulatory interactions underlying control of mitochondrial function in vivo is beginning to emerge, and although apparently contradictory findings still exist we believe that the network of regulatory protein interactions involving the PTP and CyPs in physiology and pathology will increase our repertoire for therapeutic interventions in heart disease. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection. © 2011 Elsevier B.V
Effect of myocardial calcium overloading during ischaemia and reperfusion on ATP synthesis.
No full textMechanism of the cardiac protective action of betablockers during ischaemia and reperfusion.
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