1,721,162 research outputs found
Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review
Full text linkINTRODUCTION: Oral mucositis (OM) is a major side effect of cancer therapy, which is associated with significant symptoms, treatment delays and increased costs for the health system. It is an important component of the quality of life of cancer patients and, until now, there has been no gold standard regarding prevention or treatment of this pathology. Notwithstanding the paucity of treatment guidelines (due to limited evidence from high-quality, rigorous studies), sodium bicarbonate (SB) rinses are one of the most used agents for OM management. OBJECTIVES: A systematic review (2000–2022) was performed in order to compare and examine different agents versus sodium bicarbonate (SB) in preventing or treating OM. SOURCES: Eleven randomized controlled trials (RCT) were evaluated: four were conducted for the prevention and seven for the management of OM. The risk of bias of RCTs was assessed using the revised Cochrane risk of bias tool for randomized trials. STUDY SELECTION: According to the RoB2 evaluation for randomized trials, four RCTs were judged to be at a high risk of bias, two were rated as ‘problematic’, while five were deemed to be a low risk of bias. CONCLUSIONS: The results revealed that there was no evidence for supporting SB in OM treatment regarding management and prevention. CLINICAL SIGNIFICANCE: Results showed in this review takes on a strategic importance in the use of SB for OM management or prevention; indiscriminate use of SB could be counterproductive because it causes a sudden pH increase and it delays proper OM pharmacological treatment
Adverse Reactions to Anticancer Drugs in the Oral Cavity
Full text linkThe development, testing, and adoption into clinical practice of anticancer medications have revolutionized cancer care over the past decades. A better understanding of the biology of cancer has translated into development of novel systemic agents, as well a more effective use of older chemotherapy agents. As a consequence, cancer mortality continues to decrease. However, greater cure and disease control rates come at a price of an increased risk of adverse effects, which often affects the mouth and related structures including the oral mucosa, salivary glands, jawbones, and cranial nerves. Oral mucositis, hyposalivation, dysgeusia, and osteonecrosis of the jaw (ONJ) are some examples of the potential adverse effects of anticancer therapies to the oral cavity, which affect an increasing number of individuals living with cancer and cancer survivors and can lead to persistent discomfort, pain, dysfunction, and a notable reduction in the quality of life. Management of these oral adverse effects can be challenging, as it typically requires a multidisciplinary approach and a close collaboration between the cancer team and oral health care providers, both in primary care and in the specialist setting.
This special issue provides a useful update of some of the most significant adverse reactions to anticancer drugs in the oral cavity, with a view to inform clinical practice and inspire further research.
Multitargeted tyrosine kinase inhibitors including sunitinib, sorafenib, axitinib, and cabozantinib are increasingly used in the cancer setting, and C. Arena et al. provide in this special issue a useful systematic review on oral mucositis associated with these agents. Similarly, K. Pimolbutr et al. report on the development of ONJ associated with antiangiogenic agents in the subset of antiresorptive-naïve patients.
Prevention of toxicity is crucial in individuals due to commence and in those who have been using antiresorptive medications, and O. Di Fede et al. discuss the main strategies to reduce the risk ONJ in this patient population.
The surgical treatment of medication-related ONJ is a relatively new field of research, as this condition has been historically managed conservatively with a focus on pain management and resolution of infection. In this special issue, R. Mauceri et al. report on the use of Er,Cr:YSGG laser and platelet-rich plasma in the surgical treatment of ONJ, whereas R. Sacco et al. provide a systematic review of the efficacy of microsurgical reconstruction of the jaws using vascularized free flap in patients with medication-related ONJ.
We hope that the readers of BioMed Research International will find this special issue interesting and informative
ANALISI DELL’ESPRESSIONE DI POKEMON IN LINEE CELLULARI DI CARCINOMA SQUAMOCELLULARE DEL CAVO ORALE.
No full textMarker di apoptosi e proliferazione cellulare ed infezione da HPV in carcinomi orali e leucoplachie
No full textPossibile ruolo delle molecole di adesione nei meccanismi patogenetici delle lesioni bollose nei pemfigoidi
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Quality of life in erosive oral lichen planus patients treated with clobetasol mucoadhesive formulations – a pilot study
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