1,721,055 research outputs found
NARROW-DIAMETER IMPLANTS SUPPORTING FIXED PROSTHESES IN THE POSTERIOR MANDIBLE: 5-YEAR REPORT ON A PROSPECTIVE SINGLE-COHORT STUDY
Full text linkImplant-supported prosthetic rehabilitation after jaws reconstruction for malignancies of the oral cavity
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Solid organ transplantation and SARS-CoV-2 vaccines: is there a possible alternative?
No full textThe spread of the SARS-Cov-2 virus has been a major public health problem for 2 years, especially for those immuno-suppressed patients such as those solid organ transplant recipients (SOTRs). DNA and RNA-based vaccines represent an excellent weapon to reduce the spread of the virus, but there are currently no consolidated scientific data to support the safety and efficacy of nucleic acid-based vaccines in organ transplant patients, having not been included in the phase I-III clinical trials that considered immunosuppressive or immunodeficient state among main exclusion criteria during study subjects enrollment. Solid organ transplant recipients have a reduced humoral immune response to DNA and RNA vaccines compared to the immunocompetent counterpart, thus remaining at high risk for COVID-19. Vaccines are consid-ered safe for all SOTRs, but there are in literature some reports of problems due to the vaccination in these patients such as episode of steroid-resistant acute cellular rejection and two cases of endothelial corneal allograft rejection following immunization. It is therefore essential that the immune-incompetent population continues to practice strict precautions for covid-19 even post vaccination and to keep in mind other therapeutic and preventive tools as an additional weapon against the virus
Candida albicans and oral carcinogenesis. A brief review
No full textCurrent medical knowledge and research on patients’ management are still evolving, and several protocols on minimizing risk of infection by Candida spp. among the population have de-veloped. The aim of this work is to review the epidemiological and biomolecular characteristics and the various histopathological carcinogenesis hypothesis mechanisms that can occur during Candida albicans infections. Current evidence from the literature on the role of C. albicans during potentially malignant oral disorders and oral cancer has been sought. Thus, these biomolecular processes can give or contribute to benign lesions, also in precancerous or cancerous situations. Alongside this, the physiological microorganism oral flora (microbiota) can play a crucial role in maintaining oral health during those infections and therefore avoid carcinogenesis
Oral squamous cell carcinoma and biological markers:an update on the molecules mainly involved in oral carcinogenesis
No full textSquamous cell carcinoma (SCC) is one of the most common malignant cancer of the oral cavity encompassing at least 92.8% of all oral malignancies. Despite improved diagnostic and therapeutic methods over the 20 last years, this tumour is still characterized by a high rate of mortality. The latest advances of molecular biological methods have contributed to better understand the mechanisms involved in the oral carcinogenetic process. Deregulation of cell cycle, apoptosis and cell-cell/cell-matrix adhesions are considered the pathways mainly influencing this multistage event and scientific researches over the last decade have been performed in order to investigate the biological diagnostic and prognostic parameters related to these events (i.e. tumour growth markers, markers of tumour suppression and anti-tumour response, angiogenesis markers, markers of tumour invasion and metastatic potential, cell surface markers, intracellular markers, markers derived from arachidonic acid, and enzymatic markers). The aim of the present review was to outline the current knowledge on the role of some of these tumour biological markers in carcinogenesis of oral SC
Proliferative verrucous leukoplakia: may dental rehabilization with implants allow better qualità of life and prolong disease-free intervals?
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