1,720,985 research outputs found
Modulation of eosinophilic chemotaxis with azelastine and budesonide in allergic patients
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Evaluation of monocyte chemotactic responsiveness in uraemic patients undergoing haemodialysis with different dialytic membranes
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Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters
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Retrospective study of adverse reactions to non steroid anti-inflammatory drugs (NSAIDs): predictive value of controlled challenge with alternative drugs
No full textImmune Profiling of Polysaccharide Submicron Vesicles
Full text linkAlginate (ALG) and chitosan (CS) have been extensively used for biomedical applications; however, data relative to immune responses exerted by them are scarce. We synthesized a submicron vesicle system (SV) displaying a CS shell over an ALG core. Intravenous injection of these promising carriers could be a possible route of delivery; therefore, we evaluated their impact on human peripheral blood mononuclear cells (PBMCs). By this ex vivo approach, we established how SV chemical-physical characteristics affected the immune cells in terms of cellular uptake, viability, and state of activation. By flow cytometry, we demonstrated that SVs were internalized by PBMCs with differential trends. No substantial necrotic and apoptotic signals were recorded, and SVs weakly affected activation status of PBMCs (concerning the markers CD69, CD25, CD80, and the cytokines TNF-α and IL-6), showing high immune biocompatibility and low immunomodulating properties. Our findings gain particular value toward the biomedical applications of SVs and make these polymer-based structures more attractive for translation into clinical uses
Tailoring superparamagnetic nanoparticles for entrapment into red blood cells
No full textThe aim of the work here described is the synthesis of magnetic nanoparticles (MNPs) for the inclusion into human Red Blood Cells (RBCs) and as potential contrast agent for magnetic resonance imaging (MRI). Synthesis, characterization and preliminary in vitro tests are the main topics. Superparamagnetic iron oxide nanoparticles and manganese/zinc ferrite nanoparticles have been synthesized, by using wet-chemistry techniques such as co-precipitation and thermal decomposition methods. For biomedical application, a suitable surface coating must be grafted to MNPs surface, to preserve the colloidal stability even in physiological condition. Therefore, a biomimetic coating based on non-modified dextran was grafted to MNPs for ensuring optimal stability and low toxicity for the inclusion in living RBCs
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