1,721,068 research outputs found
Controversies in the treatment of mild asthma. What novelties and practical implications?
Full text linkMild asthma is prevalent in childhood and causes as many as 30%–40% asthma exacerbations requiring emergency visits. The management of "intermittent" and "mild persistent" asthma phenotypes is still a matter of debate, even if the role of inhaled corticosteroids, both continuous and intermittent, is a cornerstone in this field. Recent updates of the guidelines on the strategies to manage these patients are coming, since the role of inflammation in these asthma phenotypes is crucial, as well as the potential side effect and risks of short-acting beta 2 agonists overuse, prescribed as the only "as-needed" treatments. In this paper, we overview the new (r)evolution regarding intermittent and mild persistent asthma management
SCUOLE DI SPECIALIZZAZIONE IN PEDIATRIA: SURVEY SULLA FORMAZIONE IN PNEUMOLOGIA PEDIATRICA
No full textThe impact of nitrate on the groundwater assemblages of European unconsolidated aquifers is likely less severe than expected
No full textIn this study, we analyzed the structure of the stygobiotic copepod assemblages of an unconsolidated European aquifer (VO), in southern Italy, that has been subject to persistent nitrate contamination for over 15 years. To this end, we monitored 25 bores where groundwater was contaminated only by nitrate, and no other chemical pollutants were reported as being above detection limits from 2009 to 2014. We monitored these bores three times, namely in autumn 2014 and in spring and autumn 2015. We expected that the chronic exposure to high nitrate concentrations had a significant and evident impact on the stygobiotic copepod assemblages. Unexpectedly, the assemblages were highly diversified. The stygobiotic species richness (SSR) accounted 17 species, a value that exceeded the European mean value (SSR = 12 species). However, the species density was only 0.6 species/km2, lower than the European mean value (= 1.6 species/km2). Moreover, the juvenile copepods were numerically less abundant than the adults and the biomass-abundance model showed signs of alteration of the structure of the copepod assemblages. This study highlighted that (i) nitrates, even at high concentrations, probably have a less severe impact on groundwater assemblages of unconsolidated aquifers than expected and (ii) the analysis of population traits and biomasses can detect signs of alteration of these assemblages that would, otherwise, not be visible from the analysis of the sole species richness and abundances
Hydroelectric Dams Affect Hyporheic Copepod Diversity
Full text linkThis study investigates the ecological impact of a small hydroelectric power plant (SHPP) on the hyporheic zone of the venacquaro stream (VEN), a low-order groundwater-fed stream in Central Italy. The hyporheic zone, a critical ecological interface where groundwater and surface water interact, plays a pivotal role in nutrient cycling, pollutant retention, and supporting aquatic biodiversity. However, hydrological alterations from activities such as damming pose significant threats to this zone. The research employs a three-pronged approach to assess the effect of a SHPP on hyporheic copepod communities. Copepods were selected as the focal group due to their dominance in this habitat. Initially, a generalized estimating equation (GEE) model was used to evaluate changes in copepod diversity, specifically alpha and beta diversity. The study then examines environmental shifts caused by the SHPP using permutational analysis of variance (PERMANOVA) and principal component analysis (PCA). Lastly, a multivariate species distribution model (mSDM) explores correlations between environmental variables and copepod abundances. Results reveal significant alterations in copepod assemblage structure and environmental variables downstream of the SHPP. The GEE model indicates a notable shift in beta diversity, primarily driven by disruptions in hyporheic connectivity rather than environmental changes alone. This disruption favours stygobitic species downstream, suggesting the influence of groundwater upwelling. Environmental analysis shows several differences between upstream and downstream sites, with changes in parameters such as pH, temperature, and dissolved organic carbon. The study highlights the need for effective management strategies to mitigate sediment accumulation and maintain habitat quality in SHPP-affected streams. Techniques like sediment bypass tunnels (SBTs) are recommended to preserve both economic and ecological values. This research contributes to the still limited understanding of SHPP impacts on hyporheic ecosystems, emphasizing the importance of considering these effects in hydropower development and riverine ecosystem conservation
Pre- and post-operam comparison of the energy consumption of a radio base station under energy efficiency actions
No full textFor some years now, one of the dominant issues in the telecommunications sector has been energy saving, as the continuous growth in the number of connected devices and data traffic inevitably leads to an increase in the electricity needs of the facilities involved. However, the attention is often towards the energy efficiency of products used by the end consumer and data centres, neglecting the telecommunications network that manages the entire system. Nonetheless, a smart approach toward energy behaviour of Base Tranceiver Station can give significant savings in power consumptions and environmental impact. Here we show how energy retrofit, that is the set of all operations, technologies and methodologies aimed at increasing the performance of a system that was previously inefficient, can bring to energy consumption reduction, management costs optimization, and noticeable diminution of the emissions and environmental impact of the facilities. Indeed, the present study shows the pre- and post-operam comparison of the energy monitoring of a radio base station subjected to energy efficiency actions. Energy savings for the new configuration has been monitored and analysed for some weeks in summer and early autumn. A net decrease of energy consumption was measured. Simulations for the new configuration with a thermal balance model of the shelter show energy savings over the entire year of about 20% compared to that of 2013. In addition, collected experimental data have been exploited in order to optimize the operating and shelter parameters. This suggests actions for further 5% savings in energy consumption
Up to date on primary ciliary dyskinesia in children
No full textPrimary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease due to
abnormal structure and/or function of cilia, with impaired mucociliary transport leading to several respiratory
disorders. PCD can be diagnosed by the combination of thorough clinical examination with functional and ultrastructural
analysis of the cilia. This paper shows progresses in PCD diagnosis obtained by ciliogenesis in culture
evaluation of ciliated respiratory cells and by genetic analysis of mutations in candidate genes. Moreover, since
to date no specific treatments are available to correct the ciliary dysfunction, the paper shows the proper
therapeutical approach by the use of respiratory physiotherapy and regular exercise to favour airways clearance,
by antibiotics administration to control acute airway infections. Macrolides administration as antinflammatory
option is suggeste
Spatial distribution of stygobitic crustacean harpacticoids at the boundaries of groundwater habitat types in Europe
No full textThe distribution patterns of stygobitic crustacean harpacticoids at the boundaries of three different groundwater habitat types in Europe were analysed through a GIS proximity analysis and fitted to exponential models. The results showed that the highest frequency of occurrences was recorded in aquifers in consolidated rocks, followed by the aquifers in unconsolidated sediments and, finally, by the practically non-aquiferous rocks. The majority of the stygobitic harpacticoid species were not able to disperse across the boundaries between two adjacent habitats, with 66% of the species occurring in a single habitat type. The species were not evenly distributed, and 35–69% of them occurred from 2 to 6 km to the boundaries, depending on the adjacent habitat types. The distribution patterns were shaped by features extrinsic to the species, such as the hydrogeological properties of the aquifers, and by species’ intrinsic characteristics such as the preference for a given habitat type and dispersal abilities. Most boundaries between adjacent habitat types resulted to be “breaches”, that is transmissive borders for stygobitic harpacticoids, while others were “impermeable walls”, that is absorptive borders. Our results suggest that conservation measures of groundwater harpacticoids should consider how species are distributed within the different groundwater habitat types and at their boundaries to ensure the preservation of species metapopulations within habitat patches and beyond them
Jumping into the grids: mapping biodiversity hotspots in groundwater habitat types across Europe
Full text linkBiodiversity hotspots are routinely identified by grid-based analyses, despite grids encompassing different habitats, thus hindering the potential to assess which habitat type accounts for the conservation priority assigned to a grid. In this study, we aimed at identifying the main hotspots for the conservation of the European stygobitic Crustacea Copepoda Harpacticoida at the groundwater habitat scale. A multi-metric approach was used, based on six biodiversity indicators: species richness, endemicity, evolutionary origin, phylogenetic rarity, taxonomic distinctness, habitat specificity. The Hot Spot Analysis, based on the statistics Getis-Ord Gi*, was used to compare the local to the global average values of each indicator to identify hotspots of conservation. The operational units used to perform the analyses were the groundwater habitat types, in order to gather all the possible patterns of spatial occupancy in terms of habitat variability. Eight biodiversity hotspots of stygobitic Crustacea Harpacticoida were highlighted: 1) the Pyrenees (Spain and France), 2) the Jura Massif (France), 3) the Alpine arc (France, Switzerland and Italy) embracing southward the River Po alluvial plain and the Slovenian External Dinarides, 4) the Central Apennines (Italy), 5) the Carpathian and Balkan mountains in Romania and at the boundary between western Bulgaria and north-west Macedonia, 6) the Dinaric Alps (from Croatia to Albania), 7) the Sardinia Island, 8) an area in central-northern Europe embracing Denmark, the Netherlands and Germany. The hotspots showed a clear spatial distribution in southern Europe where they were distributed predominantly south to the 45th parallel, in line to what reiteratively observed in previous studies. Many hotspots embraced more than one habitat type. The adoption of discrete groundwater habitat types as working spatial units rather than grids provided a higher resolution of where the stygobitic harpacticoid species effectively live, with the possibility of intervening more precisely to preserve them and their habitats
Primary Prevention of Pediatric Asthma through Nutritional Interventions
Full text linkAsthma is the most common chronic non-communicable disease in children, the pathogenesis of which involves several factors. The increasing burden of asthma worldwide has emphasized the need to identify the modifiable factors associated with the development of the disease. Recent research has focused on the relationship between dietary factors during the first 1000 days of life (including pregnancy)—when the immune system is particularly vulnerable to exogenous interferences—and allergic outcomes in children. Specific nutrients have been analyzed as potential targets for the prevention of childhood wheeze and asthma. Recent randomized controlled trials show that vitamin D supplementation during pregnancy, using higher doses than currently recommended, may be protective against early childhood wheezing but not school-age asthma. Omega-3 fatty acid supplementation during pregnancy and infancy may be associated with a reduced risk of childhood wheeze, although the evidence is conflicting. Data from observational studies suggest that some dietary patterns during pregnancy and infancy might also influence the risk of childhood asthma. However, the quality of the available evidence is insufficient to allow recommendations regarding dietary changes for the prevention of pediatric asthma. This review outlines the available high-quality evidence on the role of prenatal and perinatal nutritional interventions for the primary prevention of asthma in children and attempts to address unmet areas for future research in pediatric asthma prevention
Assessing energy performance and critical issues of a large wastewater treatment plant through full-scale data benchmarking
No full textThe wastewater sector accounts for 25% of the global energy demand in the water sector. Since this consumption is expected to increase in the forthcoming years, energy optimization strategies are needed. A truly effective planning of energy improvement measures requires a detailed knowledge of a system, which can only be achieved through energy audit and real-time monitoring. In order to improve the identification of critical issues related to the use of energy resources within a wastewater treatment plant (WWTP), the paper shows the results of a monitoring campaign performed on a large WWTP in southern Italy. Data obtained for the audit cover a 4-year timeframe (2014-2017). Energy-environmental performance has been evaluated through the benchmarking of: system variables, specific consumptions, and operational indicators. Moreover, by using a real-time data measurement and acquisition system it has been possible to evaluate the real performance of the most energy-intensive apparatus of the plant (a turbo-blower), over a period of 8 months. The main results indicate that (a) the plant is mainly affected by a massive capture of infiltrations, working in conditions close to the maximum hydraulic capacity, (b) real-time energy measurements are necessary to accurately characterize plant consumptions and adequately assess their critical aspects
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